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Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor
Biomolecules, 2020 The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein.
Jean-Pierre Changeux
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Pharmacological Research, 2023 Initiated by findings that Alzheimer’s disease is associated with a profound loss of cholinergic markers in human brain, decades of studies have examined the interactions between specific subtypes of nicotinic acetylcholine receptors and amyloid-β ...
Paul Whiteaker, Andrew A. George
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Heliyon, 2022 Rabies causes approximately 60,000 casualties annually and has a case fatality rate approaching 100% once clinical signs occur. The glycoprotein on the surface of the virion is important for the host immune response and facilitates interaction of the ...
Marianne Lian +2 more
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Pharmacological receptors of nematoda as target points for action of antiparasitic drugs [PDF]
Veterinarski Glasnik, 2010 Cholinergic receptors of parasitic nematodes are one of the most important possible sites of action of antiparasitic drugs. This paper presents some of our own results of electrophysiological and pharamcological examinations of nicotinic and muscarinic ...
Trailović Saša M. +3 more
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Neonicotinoids disrupt memory, circadian behaviour and sleep
Scientific Reports, 2021 Globally, neonicotinoids are the most used insecticides, despite their well-documented sub-lethal effects on beneficial insects. Neonicotinoids are nicotinic acetylcholine receptor agonists.
Kiah Tasman +4 more
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International Journal for Parasitology: Drugs and Drug Resistance, 2020 Nicotinic acetylcholine receptors are an important class of excitatory receptors in the central nervous system of arthropods. In the ticks Ixodes ricinus, the functional and pharmacological properties of nicotinic receptors located in their neurons are ...
Anaïs Le Mauff +8 more
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Neuregulin upregulates microglial α7 nicotinic acetylcholine receptor expression in immortalized cell lines: implications for regulating neuroinflammation. [PDF]
PLoS ONE, 2013 Neuregulin, previously known as ARIA, is a signaling protein involved in cell survival, synaptic plasticity, cell communication and differentiation. Neuregulin has also been described as a potent inducer of acetylcholine receptor transcription in muscle ...
Malwina Mencel +2 more
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The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor
Pharmacological Research, 2023 Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunits were
Ana Belén Elgoyhen
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Journal of Pharmacological Sciences, 2010 We have previously shown that chronic donepezil treatment induces nicotinic acetylcholine receptor up-regulation and enhances the sensitivity of the neurons to the neuroprotective effect of donepezil. Further analyses revealed that the nicotinic receptor
Yuki Takada-Takatori +6 more
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Toxics, 2018 Among the neurotoxicants contained in tobacco smoke, if absorbed during pregnancy, nicotine significantly affects α7-nicotinic acetylcholine receptors, which play essential roles in the development of the brainstem regions receiving cholinergic ...
Anna Maria Lavezzi
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