Results 11 to 20 of about 1,317,031 (279)

Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Lee R, Kim G, Black ER, Kim S.
europepmc   +2 more sources

Nicotinic acetylcholine receptors [PDF]

British Journal of Pharmacology, 2018
This themed section of the British Journal of Pharmacology is the product of a conference that focussed on nicotinic ACh receptors (nAChRs) that was held on the Greek island of Crete from 7 to 11 May 2017. ‘Nicotinic acetylcholine receptors 2017’ was the fourth in a series of triennial international meetings that have provided a regular forum for ...
Wonnacott, S, Bermudez, I, Millar, NS, Tzartos, SJ   +3 more
openaire   +4 more sources

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure [PDF]

, 2012
Background: Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking ...
Timpson, NJ, Upton, Mark N, Johnstone, Elaine, Vineis, Paolo, Morris, Richard W, Johnson, Paul C. D., Johnson, P.C.D., Uhl, GR, Amuzu, A., Aveyard, P., Munafò, Marcus R., Sattar, N, Watt, G., Walther, Donna, Ebrahim, S, Timofeeva, M.N., Hingorani, AD, Upton, M.N., Morris, Richard W., Johnson, PC, Riboli, E., Munafò, Marcus R, Watt, Graham, Ebrahim, Shah, Relton, C., Jefferis, BJ, Timofeeva, Maria N., Casas, Juan P., Riboli, E, Riboli, Elio, Padmanabhan, S., Palmer, T.M., Prieto-Merino, D, Jefferis, Barbara J., Vineis, P., Munafo, M.R., Amuzu, Antoinette, Prieto-Merino, D., ?, ?, Brennan, P., Hingorani, Aroon D, Padmanabhan, Sandosh, Uhl, G.R., Morris, RW, Uhl, George R, Prieto-Merino, David, Johnson, Paul CD, Timpson, Nicholas J., Whincup, PH, Whincup, P.H., Palmer, Tom M, Johnstone, E.C., Sattar, N., Johnstone, Elaine C., Johnson, Paul C D, Hingorani, A.D., Jefferis, B.J., Brennan, P, Upton, Mark N., Davey Smith, George, Upton, MN, EPIC Study Group, Ebrahim, S., Davey Smith, G, Jefferis, Barbara J, Whincup, Peter H, Uhl, George R., Timofeeva, MN, Timofeeva, Maria N, Aveyard, P, Timpson, Nicholas J, Relton, Caroline, Sattar, Naveed, Casas, Juan P, Amuzu, A, Brennan, Paul, Munafò, MR, Palmer, TM, Relton, C, Walther, D., Vineis, P, Timpson, N.J., Watt, G, Hingorani, Aroon D., Casas, JP, Johnstone, Elaine C, Padmanabhan, S, Casas, J.P., Davey Smith, G., Palmer, Tom M., Johnstone, EC, Walther, D, Whincup, Peter H., Morris, R.W., Aveyard, Paul   +94 more
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Nicotinic acetylcholine receptors and epilepsy

Pharmacological Research, 2023
Despite recent advances in understanding the causes of epilepsy, especially the genetic, comprehending the biological mechanisms that lead to the epileptic phenotype remains difficult. A paradigmatic case is constituted by the epilepsies caused by altered neuronal nicotinic acetylcholine receptors (nAChRs), which exert complex physiological functions ...
Becchetti A., Grandi L. C., Cerina M., Amadeo A.   +3 more
openaire   +5 more sources

Palmitoylation of Nicotinic Acetylcholine Receptors [PDF]

Journal of Molecular Neuroscience, 2009
It is well established that nicotinic acetylcholine receptors (nAChRs) undergo a number of different posttranslational modifications, such as disulfide bond formation, glycosylation, and phosphorylation. Recently, our laboratory has developed more sensitive assays of protein palmitoylation that have allowed us and others to detect the palmitoylation of
J K, Alexander, A P, Govind, R C, Drisdel, M P, Blanton, Y, Vallejo, T T, Lam, W N, Green   +6 more
openaire   +2 more sources

Nicotinic acetylcholine receptor mutations [PDF]

Epilepsia, 2010
SummaryAutosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) is characterized by clusters of brief motor seizures. This rare syndrome is caused by mutations in at least two subunit genes of the neuronal nicotinic acetylcholine receptor (nAChR). Some of these mutations seem to increase the risk for additional neurologic symptoms.
Ortrud K. Steinlein, Sunao Kaneko, Shinichi Hirose   +2 more
openaire   +1 more source

Upregulation of alpha 7 nicotinic receptors by acetylcholinesterase c-terminal peptides [PDF]

, 2009
Background: The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Bond, Cherie E., Cherie E Bond, Greenfield Susan A., Susan A Greenfield, Greenfield, SA, Martina Zimmermann, Zimmermann, M, Bond Cherie E., Greenfield, Susan A, Bond, CE, Zimmermann Martina, Greenfield, Susan A., Bond, Cherie E, Zimmermann, Martina, Greenfield, Susan   +14 more
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Scanning curves and kinetics of the acetylcholine/acetylcholine receptor hysteresis [PDF]

, 1988
Neumann E, Boldt E, Rauer B, Wolf H, Chang HW. Scanning curves and kinetics of the acetylcholine/acetylcholine receptor hysteresis. Bioelectrochemistry and Bioenergetics.
Hendrik Wolf, Boldt, Elvira, Chang, Hai Won, Eberhard Neumann, Rauer, Barbara, Elvira Boldt, Wolf, Hendrik, Hai Won Chang, Barbara Rauer, Neumann, Eberhard   +9 more
core   +1 more source

Expression of the α7 nicotinic acetylcholine receptor in human lung cells

Respiratory Research, 2005
Background We and others have shown that one of the mechanisms of growth regulation of small cell lung cancer cell lines and cultured pulmonary neuroendocrine cells is by the binding of agonists to the α7 neuronal nicotinic acetylcholine receptor.
Schuller Hildegard M, Dhar Madhu, Plummer Howard K   +2 more
doaj   +1 more source

Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids [PDF]

, 2012
This dissertation primarily describes structure-function studies of the nicotinic acetylcholine receptors (nAChRs). These studies use a combination of unnatural amino acid mutagenesis and electrophysiology to determine the specific molecular interactions
Puskar, Nyssa Leigh
core   +1 more source