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Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors [PDF]
Current Neuropharmacology, 2018 Neuronal nicotinic acetylcholine receptors (nAChRs) belong to a super-family of Cysloop ligand-gated ion channels that respond to endogenous acetylcholine (ACh) or other cholinergic ligands. These receptors are also the targets of drugs such as nicotine (the main addictive agent delivered by cigarette smoke) and are involved in a variety of ...
Zoli Michele +3 more
openaire +3 more sources
Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
Nature Communications, 2016 Allergic asthma is a complex and chronic inflammatory disorder that is associated with airway hyperreactivity (AHR) and driven by Th2 cytokine secretion.
Lauriane Galle-Treger +7 more
semanticscholar +1 more source
Cell Reports, 2016 Monoamine and acetylcholine neurotransmitters from the autonomic nervous system (ANS) regulate insulin secretion in pancreatic islets. The molecular mechanisms controlling neurotransmitter signaling in islet β cells and their impact on diabetes ...
Elvira Ganic +14 more
doaj +1 more source
Neural Regeneration Research, 2016 Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine nicotinic postsynaptic receptors located at the neuromuscular junction.
Hai-peng Huang, Hong Pan, Hong-feng Wang
doaj +1 more source
Data in Brief, 2020 This manuscript is a companion paper to Ulleryd M.U. et al., “Stimulation of alpha 7 nicotinic acetylcholine receptor (α7nAChR) inhibits atherosclerosis via immunomodulatory effects on myeloid cells” Atherosclerosis, 2019 [1]. Data shown here include RNA
Marcus A. Ulleryd +10 more
doaj +1 more source
Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment.
Neuropharmacology, 2015 Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of cholinergic tone, and acetylcholine (ACh) levels in the brain, which were ...
S. Lombardo, U. Maskos
semanticscholar +1 more source
Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation
Journal of Neuroimmune Pharmacology, 2015 Inflammatory responses to stimuli are essential body defenses against foreign threats. However, uncontrolled inflammation may result in serious health problems, which can be life-threatening.
C. Báez-Pagán +2 more
semanticscholar +1 more source
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine
International review of neurobiology, 2015 Nicotinic acetylcholine receptors (nAChRs) belong to the “Cys-loop” superfamily of ligand-gated ion channels that includes GABAA, glycine, and serotonin (5-HT3) receptors.
J. Dani
semanticscholar +1 more source
Structure of the native muscle-type nicotinic receptor and inhibition by snake venom toxins
Neuron, 2020 Summary The nicotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of binding of the neurotransmitter acetylcholine into opening of its central pore.
Mahfuzur Rahman +7 more
semanticscholar +1 more source
Ticks and Tick-Borne DiseasesACh is known to be an excitatory neurotransmitter in the central nervous system of several arthropod species. Nicotinic acetylcholine receptors are involved in rapid neurotransmission and are the target of compounds used as acaricides.
Khalid Boussaine +5 more
doaj +1 more source