Results 31 to 40 of about 5,544 (202)
Nicotinic receptor Alpha7 expression during tooth morphogenesis reveals functional pleiotropy. [PDF]
PLoS ONE, 2012 The expression of nicotinic acetylcholine receptor (nAChR) subtype, alpha7, was investigated in the developing teeth of mice that were modified through homologous recombination to express a bi-cistronic IRES-driven tau-enhanced green fluorescent protein (
Scott W Rogers, Lorise C Gahring
doaj +1 more source
In vivo evaluation of alpha7 nicotinic acetylcholine receptor agonists [11C]A-582941 and [11C]A-844606 in mice and conscious monkeys. [PDF]
PLoS ONE, 2010 BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Jun Toyohara +6 more
doaj +1 more source
Frontiers in Immunology, 2020 Nicotine acts as a potent modulator of normal cellular responses through the nicotinic acetylcholine receptor subtype alpha7. In a mouse genetic model of alpha7 receptor dysfunction, alpha7E260A:G, 85 percent of 18 month-old mice exhibit an age ...
Scott W. Rogers +4 more
doaj +1 more source
iMeta, Volume 2, Issue 4, November 2023., 2023 We obtained 72 strains of Latilactobacillus sakei from 120 fermentation and fecal samples across China. In total, 16 strains from different sources were initially screened in an in vitro Caco‐2 model. Subsequently, six strains (four exhibiting effectiveness and two exhibiting ineffectiveness) were selected for further validation in an in vivo colitis ...
Yaru Liu +9 more
wiley +1 more source
Psychopharmacology, 2020 Working memory deficits are present in schizophrenia (SZ) but remain insufficiently resolved by medications. Similar cognitive dysfunctions can be produced acutely in animals by elevating brain levels of kynurenic acid (KYNA).
David Phenis +5 more
semanticscholar +1 more source
The knowns and unknowns of cardiac autoimmunity in viral myocarditis
Reviews in Medical Virology, Volume 33, Issue 6, November 2023., 2023 Abstract Myocarditis can result from various infectious and non‐infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the ...
Kiruthiga Mone, Jay Reddy
wiley +1 more source
Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3
Protein Science, Volume 32, Issue 9, September 2023., 2023 Abstract Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface.
Jennifer D. Noonan, Robin N. Beech
wiley +1 more source
Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. [PDF]
PLoS Computational Biology, 2006 The initial coupling between ligand binding and channel gating in the human alpha7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-
Xiaolin Cheng +4 more
doaj +1 more source
The FASEB Journal, Volume 37, Issue 9, September 2023., 2023 (A) Mice acutely exposed to an obesogenic diet have higher TNFα and Let‐7a, while lower Chrna7 levels in the hypothalamus, as well as the hypothalamic neuronal cells exposed to fatty acids overload. (B) In vitro assays confirmed that Let‐7a can directly regulate Chrna7 levels. (C) When the hypothalamic neuronal cells exposed to fatty acids overload are
Laís A. P. Simino +11 more
wiley +1 more source