Results 11 to 20 of about 4,718 (156)

Cas9‐ and Cas12a‐mediated excision and replacement of the celiac disease‐related α‐gliadin immunogenic complex in hexaploid wheat [PDF]

Plant Biotechnology Journal, Volume 23, Issue 9, Page 3798-3813, September 2025.
Summary Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α‐gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33‐mer, along with numerous variants.
Miriam Marín‐Sanz, Susana Sánchez‐León, María H. Guzmán‐López, Colby G. Starker, Daniel F. Voytas, Francisco Barro   +5 more
wiley   +2 more sources

HIV, smoking, and the brain: a convergence of neurotoxicities [PDF]

AIDS Research and Therapy
Purpose of review The purpose of this review is to characterize the combined effects of tobacco smoking and human immunodeficiency virus (HIV) infection in people with HIV (PWH) and identify possible therapeutic targets through shared mechanisms for ...
Benjamin L. Orlinick, Shelli F. Farhadian   +1 more
doaj   +2 more sources

Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice [PDF]

Scientific Reports
There is currently no treatment for cognitive-impairment associated with schizophrenia (CIAS). Animal and human studies suggest that nicotinic cholinergic agonists and 5-HT3 antagonists have potential therapeutic benefits.
Lorena R. Lizarraga-Valderrama, Stuart Williams, David J. G. Watson, Kiri T. Granger, Claire L. Gibson, Paula M. Moran   +5 more
doaj   +2 more sources

18 F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation [PDF]

EJNMMI Research
Background The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury.
Yong-il Kim, Seung Hak Lee, Jin Hwa Jung, Seog-Young Kim, Nare Ko, Sang Ju Lee, Seung Jun Oh, Jin-Sook Ryu, Dabin Ko, Won Kim, Kyunggon Kim   +10 more
doaj   +2 more sources

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig [PDF]

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +2 more sources

Quantification of Proliferating and Mitotically Active Retinal Cells in Mice by Flow Cytometry [PDF]

Bio-Protocol
Adult mammals lack the ability to regenerate retinal neurons after injury. However, in previous studies from this lab, topical application of the selective alpha7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, has been associated with an ...
Hope Vanzo-Sparks, Sarah Webster, Mark Webster, Cindy Linn   +3 more
doaj   +2 more sources

Neuregulin-1 as a Context-Dependent Regulator of Neuroinflammation and Neural Repair: Mechanisms, Disease Relevance, and Therapeutic Challenges [PDF]

Cells
Neuroinflammation is a coordinated response to central nervous system injury and disease involving resident glia, neurons, the neurovascular unit, and infiltrating immune cells.
Gregory D. Ford, Christopher McGinley, Oluwafayokemi Oyolola, Oyinkansola Adeyemi, Monique C. Surles-Zeigler, Shokofeh Rahimpour, Byron D. Ford   +6 more
doaj   +2 more sources

Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.

, 2000
Two homomer-forming nicotinic acetylcholine receptor subunits with 47% identity in their amino acid sequences were employed to compare the actions of cholinergic anthelmintics and ivermectin on expressed vertebrate and nematode nicotinic receptors of ...
Sattelle, D B, Mongan, N P, Raymond, V
core   +10 more sources

Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure

Frontiers in Immunology, 2020
Nicotine acts as a potent modulator of normal cellular responses through the nicotinic acetylcholine receptor subtype alpha7. In a mouse genetic model of alpha7 receptor dysfunction, alpha7E260A:G, 85 percent of 18 month-old mice exhibit an age ...
Scott W. Rogers, Scott W. Rogers, Elizabeth J. Myers, Lorise C. Gahring, Lorise C. Gahring   +4 more
doaj   +1 more source

Intraspecific difference of Latilactobacillus sakei in inflammatory bowel diseases: Insights into potential mechanisms through comparative genomics and metabolomics analyses

iMeta, Volume 2, Issue 4, November 2023., 2023
We obtained 72 strains of Latilactobacillus sakei from 120 fermentation and fecal samples across China. In total, 16 strains from different sources were initially screened in an in vitro Caco‐2 model. Subsequently, six strains (four exhibiting effectiveness and two exhibiting ineffectiveness) were selected for further validation in an in vivo colitis ...
Yaru Liu, Hui Duan, Ying Chen, Chengcheng Zhang, Jianxin Zhao, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Leilei Yu, Wei Chen   +9 more
wiley   +1 more source