Frontiers in Pharmacology, 2019 Alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in learning and memory and are promising targets for pharmacological cognitive enhancement.
Zsolt Kristof Bali +2 more
exaly +4 more sources
Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning [PDF]
European Neuropsychopharmacology, 2018 Cognitive impairments, e.g., reward learning, are present in various psychiatric disorders and warrant treatment. Improving reward-related learning could synergistically enhance psychosocial treatments and cognition generally. A critical first step is to
Morgane Milienne-Petiot +2 more
exaly +7 more sources
Heliyon, 2020 Alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also
Khalil Hajiasgharzadeh +2 more
exaly +4 more sources
Nicotinic receptor alpha7 expression identifies a novel hematopoietic progenitor lineage. [PDF]
PLoS ONE, 2013 How inflammatory responses are mechanistically modulated by nicotinic acetylcholine receptors (nAChR), especially by receptors composed of alpha7 (α7) subunits, is poorly defined.
Lorise C Gahring +8 more
doaj +5 more sources
Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases [PDF]
Cellular and Molecular Life Sciences, 2010 In recent years the etiopathology of a number of debilitating diseases such as type 2 diabetes, arthritis, atherosclerosis, psoriasis, asthma, cystic fibrosis, sepsis, and ulcerative colitis has increasingly been linked to runaway cytokine-mediated ...
Merouane Bencherif +2 more
exaly +4 more sources
Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia. [PDF]
Nicotine & Tobacco Research, 2018 While current treatments for schizophrenia often provide much relief for positive symptoms such as hallucinations, other symptoms, particularly cognitive deficits, persist and contribute to substantial suffering and reduced quality of life for patients ...
J. Tregellas, Korey P. Wylie
semanticscholar +3 more sources
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia. [PDF]
PLoS ONE, 2016 The development of alpha7 nicotinic acetylcholine receptor agonists is considered a promising approach for the treatment of cognitive symptoms in schizophrenia patients. In the present studies we characterized the novel agent, (2R)-N-(6-(1H-imidazol-1-yl)
Linda J Bristow +22 more
doaj +2 more sources
The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation [PDF]
British Journal of Pharmacology, 2007 The physiological regulation of the immune system encompasses comprehensive anti‐inflammatory mechanisms that can be harnessed for the treatment of infectious and inflammatory disorders. Recent studies indicate that the vagal nerve, involved in control of heart rate, hormone secretion and gastrointestinal motility, is also an immunomodulator.
W. Jonge, Luis Ulloa, Luis Ulloa
semanticscholar +4 more sources
Alpha7 nicotinic receptors as therapeutic targets for Parkinson’s disease [PDF]
Biochemical Pharmacology, 2015 Accumulating evidence suggests that CNS α7 nicotinic acetylcholine receptors (nAChRs) are important targets for the development of therapeutic approaches for Parkinson’s disease.
M. Quik +3 more
semanticscholar +3 more sources
Cas9- and Cas12a-mediated excision and replacement of the celiac disease-related α-gliadin immunogenic complex in hexaploid wheat. [PDF]
Plant Biotechnol JSummary Celiac disease (CD) is a chronic enteropathy affecting approximately 1% of the global population. Wheat α‐gliadins are a major contributor to the autoimmune response, as they contain one of the most immunogenic peptides, the 33‐mer, along with numerous variants.
Marín-Sanz M +5 more
europepmc +2 more sources