Results 21 to 30 of about 4,718 (156)

The knowns and unknowns of cardiac autoimmunity in viral myocarditis

Reviews in Medical Virology, Volume 33, Issue 6, November 2023., 2023
Abstract Myocarditis can result from various infectious and non‐infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the ...
Kiruthiga Mone, Jay Reddy
wiley   +1 more source

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. [PDF]

PLoS Computational Biology, 2006
The initial coupling between ligand binding and channel gating in the human alpha7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-
Xiaolin Cheng, Hailong Wang, Barry Grant, Steven M Sine, J Andrew McCammon   +4 more
doaj   +1 more source

Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3

Protein Science, Volume 32, Issue 9, September 2023., 2023
Abstract Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface.
Jennifer D. Noonan, Robin N. Beech
wiley   +1 more source

Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. [PDF]

PLoS ONE, 2009
Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons.
Jun Il Kang, Elvire Vaucher
doaj   +1 more source

Hypothalamic α7 nicotinic acetylcholine receptor (α7nAChR) is downregulated by TNFα‐induced Let‐7 overexpression driven by fatty acids

The FASEB Journal, Volume 37, Issue 9, September 2023., 2023
(A) Mice acutely exposed to an obesogenic diet have higher TNFα and Let‐7a, while lower Chrna7 levels in the hypothalamus, as well as the hypothalamic neuronal cells exposed to fatty acids overload. (B) In vitro assays confirmed that Let‐7a can directly regulate Chrna7 levels. (C) When the hypothalamic neuronal cells exposed to fatty acids overload are
Laís A. P. Simino, Mayara N. Baqueiro, Carolina Panzarin, Priscilla K. F. Lopes, Mariana M. Góis, Fernando M. Simabuco, Letícia M. Ignácio‐Souza, Marciane Milanski, Michael G. Ross, Mina Desai, Adriana S. Torsoni, Marcio A. Torsoni   +11 more
wiley   +1 more source

Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats

Frontiers in Pharmacology, 2019
Alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in learning and memory and are promising targets for pharmacological cognitive enhancement.
Zsolt Kristóf Bali, Zsolt Kristóf Bali, Zsolt Kristóf Bali, Nóra Bruszt, Nóra Bruszt, Sai Ambika Tadepalli, Sai Ambika Tadepalli, Roland Csurgyók, Roland Csurgyók, Lili Veronika Nagy, Lili Veronika Nagy, Márton Tompa, Márton Tompa, István Hernádi, István Hernádi, István Hernádi   +15 more
doaj   +1 more source

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption

Frontiers in Behavioral Neuroscience, 2023
Rationale and Objectives: Ethanol acts directly on the α7 Nicotinic acetylcholine receptor (α7). Adolescent-binge alcohol exposure (ABAE) produces deleterious consequences during adulthood, and data indicate that the α7 receptor regulates these damaging ...
Zachary A. Rodd, Zachary A. Rodd, H. Scott Swartzwelder, R. Aaron Waeiss, R. Aaron Waeiss, Serhii O. Soloviov, Serhii O. Soloviov, Debomoy K. Lahiri, Debomoy K. Lahiri, Debomoy K. Lahiri, Debomoy K. Lahiri, Debomoy K. Lahiri, Eric A. Engleman, Eric A. Engleman, William A. Truitt, William A. Truitt, Richard L. Bell, Richard L. Bell, Sheketha R. Hauser, Sheketha R. Hauser   +19 more
doaj   +1 more source

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Molecules, 2021
We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice.
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. López   +4 more
doaj   +1 more source

PICK1 interacts with alpha7 neuronal nicotinic acetylcholine receptors and controls their clustering [PDF]

, 2007
Central to synaptic function are protein scaffolds associated with neurotransmitter receptors. Alpha7 neuronal nicotinic acetylcholine receptors (nAChRs) modulate network activity, neuronal survival and cognitive processes in the CNS, but protein ...
Huh, K H, Susanne Erb-Vögtli, Kyung-Hye Huh, Erb-Vögtli, S, Nishimune, A, Bürli, T, Mark I. Rees, Jean-Marc Fritschy, Dubravka Göckeritz-Dujmovic, Huh, KH, Andreas Wiesner, Fritschy, JM, Fuhrer, C, Fritschy, J M, Fuhrer, Christian; https://orcid.org/, Göckeritz-Dujmovic, D, Jeremy M. Henley, Henley, JM, Christian Fuhrer, Thomas Bürli, Atsushi Nishimune, Henley, J M, Rees, MI, Kristin Baer, Martijn Moransard, Baer, K, Wiesner, A, Rees, M I, Mark Rees, Moransard, M   +29 more
core   +1 more source

Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation

Journal of Neuroinflammation, 2010
Background A major site of initiation of inflammatory responses upon physical perturbation(s) and infection by invading organisms is the skin. Control of responses in this organ is, in part, modulated by the neuronal nicotinic acetylcholine receptor ...
Osborne Amber V, Gahring Lorise C, Reed Michelle, Rogers Scott W   +3 more
doaj   +1 more source