Alpha7 Nicotinic Acetylcholine Receptor Is a Target in Pharmacology and Toxicology [PDF]
International Journal of Molecular Sciences, 2012 Alpha7 nicotinic acetylcholine receptor (α7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system ...
M. Pohanka
semanticscholar +3 more sources
Toxics, 2020 Current cigarette smoking is associated with chronic kidney disease (CKD) or death from end-stage renal disease (ESRD). Mainstream cigarette smoke includes over 4000 compounds.
Cai-Mei Zheng +2 more
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HIV, smoking, and the brain: a convergence of neurotoxicities [PDF]
AIDS Research and TherapyPurpose of review The purpose of this review is to characterize the combined effects of tobacco smoking and human immunodeficiency virus (HIV) infection in people with HIV (PWH) and identify possible therapeutic targets through shared mechanisms for ...
Benjamin L. Orlinick +1 more
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18 F-ASEM PET/MRI targeting alpha7-nicotinic acetylcholine receptor can reveal skeletal muscle denervation [PDF]
EJNMMI ResearchBackground The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury.
Yong-il Kim +10 more
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Investigation of varenicline and tropisetron in latent inhibition and novel object recognition in mice [PDF]
Scientific ReportsThere is currently no treatment for cognitive-impairment associated with schizophrenia (CIAS). Animal and human studies suggest that nicotinic cholinergic agonists and 5-HT3 antagonists have potential therapeutic benefits.
Lorena R. Lizarraga-Valderrama +5 more
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Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig [PDF]
Frontiers in NeuroimagingThe alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen +11 more
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The expression of nicotinic receptor alpha7 during cochlear development [PDF]
Brain and Behavior, 2012 AbstractNicotinic acetylcholine receptor alpha7 expression was examined in the developing and adult auditory system using mice that were modified through homologous recombination to coexpress either GFP (alpha7GFP) or Cre (alpha7Cre), respectively.
Scott W Rogers, Lorise C Gahring
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Quantification of Proliferating and Mitotically Active Retinal Cells in Mice by Flow Cytometry [PDF]
Bio-ProtocolAdult mammals lack the ability to regenerate retinal neurons after injury. However, in previous studies from this lab, topical application of the selective alpha7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, has been associated with an ...
Hope Vanzo-Sparks +3 more
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Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice [PDF]
Psychopharmacology, 2017 Smoking is the leading cause of preventable death in the USA, but quit attempts result in withdrawal-induced cognitive dysfunction and predicts relapse.
K. Higa +11 more
semanticscholar +5 more sources
Nicotinic receptor Alpha7 expression during mouse adrenal gland development. [PDF]
PLoS ONE, 2014 The nicotinic acetylcholine receptor alpha 7 (α7) is a ligand-activated ion channel that contributes to a diversity of cellular processes involved in development, neurotransmission and inflammation. In this report the expression of α7 was examined in the
Lorise C Gahring +3 more
doaj +4 more sources