Results 11 to 20 of about 6,467 (115)

Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages

Marine Drugs, 2022
The α7 nicotinic acetylcholine receptor (nAChR) is widely distributed in the central and peripheral nervous systems and is closely related to a variety of nervous system diseases and inflammatory responses.
Yao Tan, Zhaoli Chu, Hongyu Shan, Dongting Zhangsun, Xiaopeng Zhu, Sulan Luo   +5 more
doaj   +1 more source

Activation of α7 nicotinic acetylcholine receptor promotes HIV-1 transcription

Cell Insight, 2022
Alpha7 nicotinic acetylcholine receptor (α7 nAChR), a hub of the cholinergic anti-inflammatory pathway (CAP), is required for the treatment of inflammatory diseases.
Jing Wen, Caiqi Zhao, Jie Chen, Shuting Song, Zhekai Lin, Shitao Xie, Huaxin Qi, Jianhua Wang, Xiao Su   +8 more
doaj   +1 more source

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer. [PDF]

Front Cell Dev Biol, 2021
Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth.
Bychkov ML, Shulepko MA, Shlepova OV, Kulbatskii DS, Chulina IA, Paramonov AS, Baidakova LK, Azev VN, Koshelev SG, Kirpichnikov MP, Shenkarev ZO, Lyukmanova EN.   +11 more
europepmc   +2 more sources

Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor

Molecules, 2023
Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders.
Karanveer Singh, Allyson Ngo, Oshini V. Keerthisinghe, Krystal K. Patel, Christopher Liang, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. [PDF]

PLoS ONE, 2011
The α7 nicotinic acetylcholine receptor (nAChR) is a potential target for the treatment of cognitive deficits in patients with schizophrenia, ADHD and Alzheimer's disease.
Morten S Thomsen, Mona El-Sayed, Jens D Mikkelsen   +2 more
doaj   +1 more source

Nicotine-Mediated Regulation of Nicotinic Acetylcholine Receptors in Non-Small Cell Lung Adenocarcinoma by E2F1 and STAT1 Transcription Factors. [PDF]

PLoS ONE, 2016
Cigarette smoking is the major risk factor for non-small cell lung cancer (NSCLC), which accounts for 80% of all lung cancers. Nicotine, the addictive component of tobacco smoke, can induce proliferation, migration, invasion, epithelial-mesenchymal ...
Courtney Schaal, Srikumar Chellappan
doaj   +1 more source

The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice

Biomedicines, 2023
Nicotine, an abundant molecule in tobacco, has immunomodulatory effects on inflammatory diseases, primarily due to the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR).
Young-Eun Kim, Jae-Hyun Lee, Eun-Ju Lee, Do Hoon Kim, Mi Ryeong Jeong, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Jeehee Youn, Eun-Ju Chang, Yong-Gil Kim   +10 more
doaj   +1 more source

Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway

Journal of Neuroinflammation, 2017
Background α7 nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central nervous system and are reported to have neuroprotective properties.
Hiral Patel, Jessica McIntire, Sarah Ryan, Anthone Dunah, Ralph Loring   +4 more
doaj   +1 more source

Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals

Molecules, 2021
We previously reported that lipopolysaccharide (LPS) challenge caused microglial-mediated neuroinflammation and sickness behavior that was amplified in aged mice.
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. López   +4 more
doaj   +1 more source

The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

Biomolecules, 2020
Objective: Type 2 diabetes (T2D) occurs by deterioration in pancreatic β-cell function and/or progressive loss of pancreatic β-cell mass under the context of insulin resistance.
Blandine Gausserès, Junjun Liu, Ewout Foppen, Cécile Tourrel-Cuzin, Ana Rodriguez Sanchez-Archidona, Etienne Delangre, Céline Cruciani-Guglielmacci, Stéphanie Pons, Uwe Maskos, Bernard Thorens, Christophe Magnan, Jamileh Movassat, Kamel Maouche   +12 more
doaj   +1 more source