Results 21 to 30 of about 6,467 (115)

Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo

Frontiers in Cell and Developmental Biology, 2023
α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells.
O. V. Shlepova, O. V. Shlepova, M. A. Shulepko, V. O. Shipunova, V. O. Shipunova, M. L. Bychkov, I. D. Kukushkin, I. D. Kukushkin, I. A. Chulina, V. N. Azev, E. I. Shramova, V. A. Kazakov, A. M. Ismailova, Y. A. Palikova, V. A. Palikov, E. A. Kalabina, E. A. Shaykhutdinova, G. A. Slashcheva, E. A. Tukhovskaya, I. A. Dyachenko, A. N. Murashev, S. M. Deyev, S. M. Deyev, S. M. Deyev, M. P. Kirpichnikov, M. P. Kirpichnikov, Z. O. Shenkarev, Z. O. Shenkarev, Z. O. Shenkarev, E. N. Lyukmanova, E. N. Lyukmanova, E. N. Lyukmanova   +31 more
doaj   +1 more source

Enriched environment alleviates post-stroke cognitive impairment through enhancing α7-nAChR expression in rats [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Background: Enriched environment (EE) is a simple and effective intervention to improve cognitive function in post-stroke cognitive impairment (PSCI), partly due to the rebalancing of the cholinergic signaling pathway in the hippocampus.
Mei YUAN, Xin-Xin ZHANG, Xiao-Cui FU, Xia BI   +3 more
doaj   +1 more source

A G protein‐coupled α7 nicotinic receptor regulates signaling and TNF‐α release in microglia

FEBS Open Bio, 2017
Acetylcholine activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) in microglia attenuates neuroinflammation and regulates TNF‐α release. We used lipopolysaccharide to model inflammation in the microglial cell line EOC20 and examined signaling ...
Justin R. King, Trudy C. Gillevet, Nadine Kabbani   +2 more
doaj   +1 more source

The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials

Acta Pharmaceutica Sinica B, 2017
The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca2+-permeable ion channel implicated in cognition and neuropsychiatric disorders.
Taoyi Yang, Ting Xiao, Qi Sun, Kewei Wang   +3 more
doaj   +1 more source

Nicotine Regulates LPS-Induced Inflammatory Responses in HMC3 Microglia and Exerts Neuronal Protection. [PDF]

Mediators Inflamm
Microglia‐mediated neuroimmune responses have been implicated in central nervous system injury and disease pathogenesis. The α7 nicotinic acetylcholine receptor (α7 nAChR), which is expressed on microglia and participates in microenvironment interactions, is a key mediator of the cholinergic anti‐inflammatory pathway.
Qin Y, Yan X, Luo Y, Wang H, Tian Y, Wu X, Chen H, Hou H, Hu Q.   +8 more
europepmc   +2 more sources

α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

JCI Insight, 2021
Right ventricular (RV) fibrosis is a key feature of maladaptive RV hypertrophy and dysfunction and is associated with poor outcomes in pulmonary hypertension (PH).
Alexander Vang, Denielli da Silva Gonçalves Bos, Ana Fernandez-Nicolas, Peng Zhang, Alan R. Morrison, Thomas J. Mancini, Richard T. Clements, Iuliia Polina, Michael W. Cypress, Bong Sook Jhun, Edward Hawrot, Ulrike Mende, Jin O-Uchi, Gaurav Choudhary   +13 more
doaj   +1 more source

Nicotine Elevated Intracellular Ca2+ in Rat Airway Smooth Muscle Cells via Activating and Up-Regulating α7-Nicotinic Acetylcholine Receptor

Cellular Physiology and Biochemistry, 2014
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with airway smooth muscle (ASM) hypertrophy and hyperplasia.
Yongliang Jiang, Aiguo Dai, Yumin Zhou, Gongyong Peng, Guoping Hu, Bing Li, James S.K. Sham, Pixin Ran   +7 more
doaj   +1 more source

Recombinant Newcastle disease virus rL-RVG enhances the apoptosis and inhibits the migration of A549 lung adenocarcinoma cells via regulating alpha 7 nicotinic acetylcholine receptors in vitro

Virology Journal, 2017
Background The aim of this study were to investigate the possible pro-apoptotic mechanisms of the recombinant Newcastle disease virus (NDV) strain rL-RVG, which expresses the rabies virus glycoprotein, in A549 lung adenocarcinoma cells via the regulation
Yulan Yan, Chunxiang Su, Min Hang, Hua Huang, Yinghai Zhao, Xiaomei Shao, Xuefeng Bu   +6 more
doaj   +1 more source

Targeting α7 nicotinic acetylcholine receptors for chronic pain

Frontiers in Molecular Neuroscience, 2022
Despite rapid advances in the field of chronic pain, it remains extremely challenging in the clinic. Pain treatment strategies have not improved for decades as opioids remain the main prescribed drugs for chronic pain management.
Ya-Qun Zhou, Dai-Qiang Liu, Cheng Liu, Ai-Jun Xu, Yu-Ke Tian, Wei Mei, Xue-Bi Tian   +6 more
doaj   +1 more source

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. [PDF]

PLoS ONE, 2011
Alpha7 nicotinic acetylcholine receptor (nAChR), an essential regulator of inflammation, is abundantly expressed in hippocampal neurons, which are vulnerable to bacterial meningitis.
Feng Chi, Lin Wang, Xueye Zheng, Chun-Hua Wu, Ambrose Jong, Michael A Sheard, Wei Shi, Sheng-He Huang   +7 more
doaj   +1 more source