Results 41 to 50 of about 6,467 (115)

Effects of galantamine on social interaction impairments in cholecystokinin receptor-2 overexpression mice

Journal of Pharmacological Sciences, 2022
We examined whether galantamine (GAL), a cholinesterase inhibitor and allosteric potentiating ligand for α7 nicotinic acetylcholine receptor (nAChR), had an impact on emotional abnormalities in forebrain-specific cholecystokinin receptor-2 overexpressed ...
Shota Tanase, Takayoshi Mamiya, Shogo Nagata, Yusuke Ikawa, Ya-Ping Tang, Masayuki Hiramatsu, Toshitaka Nabeshima   +6 more
doaj   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors

Cell Discovery
The α7 nicotinic acetylcholine receptor (nAChR), a pentameric ligand-gated ion channel, plays important roles in cognition, neuroprotection, and anti-inflammation.
Sanling Liu, Yining Zheng, Haopeng Chen, Xin Li, Qipeng Yan, Wenjun Mu, Yaning Fu, Huan Chen, Hongwei Hou, Lei Liu, Changlin Tian   +10 more
doaj   +1 more source

α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.

PLoS ONE, 2015
Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cognitive functions, as well as inflammatory reactions. Their density is decreased upon Alzheimer disease accompanied by accumulation of β-amyloid (Aβ42), memory
Olena Lykhmus, Larysa Voytenko, Lyudmyla Koval, Sergiy Mykhalskiy, Victor Kholin, Kateryna Peschana, Marios Zouridakis, Socrates Tzartos, Sergiy Komisarenko, Maryna Skok   +9 more
doaj   +1 more source

Interacting with α7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages

Acta Pharmaceutica Sinica B, 2020
Acetylcholine (ACh) regulates inflammation via α7 nicotinic acetylcholine receptor (α7 nAChR). Acetylcholinesterase (AChE), an enzyme hydrolyzing ACh, is expressed in immune cells suggesting non-classical function in inflammatory responses.
Etta Y.L. Liu, Yingjie Xia, Xiangpeng Kong, Maggie S.S. Guo, Anna X.D. Yu, Brody Z.Y. Zheng, Shinghung Mak, Miranda L. Xu, Karl W.K. Tsim   +8 more
doaj   +1 more source

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107

Journal of Neuroinflammation, 2021
Background The α7 nicotinic acetylcholine receptor (α7 nAChR) negatively regulates the synthesis and release of pro-inflammatory cytokines by immune cells.
Tehila Mizrachi, Oshrit Marsha, Karen Brusin, Yael Ben-David, Ganesh A. Thakur, Adi Vaknin-Dembinsky, Millet Treinin, Talma Brenner   +7 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.

PLoS ONE, 2015
The existence of α7β2 nicotinic acetylcholine receptors (nAChRs) has recently been demonstrated in both the rodent and human brain. Since α7-containing nAChRs are promising drug targets for schizophrenia and Alzheimer's disease, it is critical to ...
Morten Skøtt Thomsen, Ruud Zwart, Daniel Ursu, Majbrit Myrup Jensen, Lars Hageman Pinborg, Gary Gilmour, Jie Wu, Emanuele Sher, Jens Damsgaard Mikkelsen   +8 more
doaj   +1 more source

Molecular imprinting for neurology: Materials, applications, and limitations

Ibrain, Volume 12, Issue 1, Page 3-37, Spring 2026.
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma, Yingqi Ma, Claudia Marino, Alessandro Poma   +3 more
wiley   +1 more source

From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management

JCC Plus, Volume 1, Issue 2, March 2026.
Important limitations exist in the current pharmacological landscape of Inflammatory Bowel Disease (IBD), such as variable response rates and treatment‐limiting adverse effects. In this review, we perform a critical assessment of the current literature on novel multimodal biophysical approaches showing alternative mechanisms of action to, and potential
Benedetta Ricchi, Alejandra A. Carriles, Samuel Elias Pineda Chavez, Stefanos Bonovas, Arianna Dal Buono, Cristina Bezzio, Alessandro Armuzzi, Stefania Vetrano   +7 more
wiley   +1 more source