Results 131 to 140 of about 37,262 (231)

An antiviral jacalin‐like lectin gene contributes to nonhost resistance and host determination of potexviruses among Brassicaceae

New Phytologist, Volume 250, Issue 5, Page 3283-3298, June 2026.
Summary Plant resistance influences the host range of pathogens; however, the mechanism driving this influence remains poorly understood. Brassicaceae species are not natural hosts of potexviruses, for reasons that have not yet been determined. This study investigated the molecular basis of nonhost resistance (NHR) to potexviruses in the Brassicaceae ...
Takumi Suzuki, Kazuya Ishikawa, Akira Yusa, Nozomu Iwabuchi, Kan Kimura, Tetsuya Yoshida, Mari Ota, Masato Suzuki, Masanobu Nishikawa, Kensaku Maejima, Shigetou Namba, Yasuyuki Yamaji   +11 more
wiley   +1 more source

Isolamento e caracterizaçao de promotor fruto-espicifico do gene CALTP1 de Coffea arabica [PDF]

, 2011
A disponibilidade de promotores endógenos, não patenteados, que regulem a expressão do transgenes de forma limitada espacial e temporalmente é uma valiosa ferramenta para programas de melhoramento.
Alves Barbosa, Eder, Bittencourt Mendes Santos, Daiene, Carvalho Andrade, Alan, Dantas de Almeida, Juliana, Gomes Barros, Leila Maria, Guitton Cotta, Michelle, Marraccini, Pierre, Soares Abreu, Mariana, Vinecky, Felipe   +8 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

A New Paradigm in the Relationship between Gut Microbiota and Breast Cancer: β-glucuronidase Enzyme Identified as Potential Therapeutic Target. [PDF]

Pathogens, 2023
Fernández-Murga ML, Gil-Ortiz F, Serrano-García L, Llombart-Cussac A.   +3 more
europepmc   +1 more source

Flunitrazepam Excretion Patterns using the Abuscreen OnTrak and OnLine Immunoassays: Comparison with GC-MS [PDF]

, 2017
A study was conducted to compare the performance of the OnLine and OnTrak immunoassays for benzodiazepines with gas chromatographic-mass spectrometric (GC-MS) analysis in detecting flunitrazepam (FNP) and its metabolites in human urine.
Brenneisen, R., Brenneisen, R., Brenner, C., ElSohly, M.A., Feng, S., Goc-Szkutnicka, K., Honasoge, S., McNally, A.J., Passarelli, J., Salamone, S.J.   +9 more
core  

The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NO3− Transporter ZmCLCa

Advanced Science, Volume 13, Issue 25, 4 May 2026.
In maize, the bHLH transcription factor ZmbHLH118 directly binds to the promoter of ZmCLCa and inhibits its expression. Tonoplast‐localized ZmCLCa mediates NO3− influx into the vacuole to regulate intracellular NO3− homeostasis, modulating nitrate uptake and metabolism, plant growth, and grain yield.
Chaonan Zhang, Elsa Demes‐Causse, Xujian Li, Zhenhui Guo, Hanshu Zhao, Huairong Cao, Yajing Song, Lijun Mu, Kaikai Zhang, Jing Zhang, Zhongtao Jia, Lixing Yuan, Alexis De Angeli, Jingbo Zhang   +13 more
wiley   +1 more source

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, Volume 18, Issue 5, Page 669-677, May 2026.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652. [PDF]

Xenobiotica, 2022
Kerins A, Koszyczarek M, Smith C, Butler P, Riley R, Madgula V, Naik N, Redinbo MR, Wilson ID.   +8 more
europepmc   +1 more source

Evaluation of Different Detection and Identification Methods of Intact Tetrahydro‐Methyltestosterone Sulfate Metabolites in Doping Control

Drug Testing and Analysis, Volume 18, Issue 5, Page 678-689, May 2026.
The micro‐scale synthesis of the six out of eight possible tetrahydro‐methyltestosterone sulfate metabolites was performed, and the synthesized materials were used as analytical standards. The analysis of post‐administration sample extracts from methyltestosterone excretion studies against these standards provides further experimental proof for their ...
Yiannis S. Angelis, Olga Goula, Polyxeni Kiousi, Panagiotis Sakellariou   +3 more
wiley   +1 more source

Virtual Screening for the Discovery of Microbiome β-Glucuronidase Inhibitors to Alleviate Cancer Drug Toxicity. [PDF]

J Chem Inf Model, 2022
Challa AP, Hu X, Zhang YQ, Hymes J, Wallace BD, Karavadhi S, Sun H, Patnaik S, Hall MD, Shen M.   +9 more
europepmc   +1 more source