Results 1 to 10 of about 134,151 (154)
When Is an Indole Not an Indole? [PDF]
Clinical Chemistry, 1998 An indole is not an indole when it is a naphthalene derivative! We routinely measure 5-hydroxyindoleacetic acid (5HIAA) by a long-established method using nitrosonaphthol, as first described by Udenfriend in 1955 (1), but with various modifications to improve specificity (2).
Kathryn Brownbill, John A Martin
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Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
ChemistryOpen, 2023 The indole moiety is an important N‐heterocycle found in natural products, and a key structural component of many value‐added chemicals including pharmaceuticals. In particular, bis(3‐indolyl)methanes (BIMs) are an important subgroup of indoles, composed
A. Sofia Santos +5 more
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Bisindolyl Maleimides and Indolylmaleimide Derivatives—A Review of Their Synthesis and Bioactivity
Pharmaceuticals, 2023 The evolution of bisindolyl maleimides and indolyl maleimide derivatives and their unique biological activities have stimulated great interest in medicinal chemistry programs.
Louise N. Cooney +5 more
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The Emergence of Insect Odorant Receptor-Based Biosensors
Biosensors, 2020 The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance ...
Jonathan D. Bohbot, Sefi Vernick
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Microorganisms, 2021 Gut microbiota metabolizes tryptophan into indole, which can influence brain and behavior. Indeed, some oxidized derivatives of indole, formed in the liver, have neuroactive properties, and indole overproduction by the gut microbiota induces an anxio ...
Catherine Philippe +8 more
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Marine Drugs, 2015 Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in ...
Netz, Natalie, Opatz, Till
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New Approaches to Indoles and Indole Alkaloids [PDF]
Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings, 2013 Second only to pyridines, indoles are among the most common aromatic scaffolds present in bioactive molecules. The 5-hydroxy indole moiety alone has currently >10,500 substructure hits Among the many indole-containing alkaloid scaffolds, ergot alkaloids comprise a notable group of natural products of great biological activities. The striking biological
Peter Wipf, Filip Petronijevic
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2-[3-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-8H-indeno[1,2-d]thiazole
IUCrData, 2019 The title molecule, C25H17ClFN3S, contains indenothiazolyl (A), pyrazolyl (B), fluorophenyl (C) and chlorophenyl (D) groups. The dihedral angles between the ring planes A/B, B/C and B/D are 14.2 (1), 83.0 (1) and 6.5 (2)°, respectively.
Gamal A. El-Hiti +4 more
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α-Glucosidase Inhibitors Based on Oleanolic Acid for the Treatment of Immunometabolic Disorders
Applied Sciences, 2023 Using oleanolic acid as a starting compound, a series of new oleanane-type triterpenic derivatives were synthesized via O-acylation (with nicotinic, isonicotinic, and methoxycinnamic acid acyl chlorides), N-amidation (with cyclic- or polyamines), the ...
Anastasiya V. Petrova +6 more
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Crystal structure and DFT study of (E)-N-[2-(1H-indol-3-yl)ethyl]-1-(anthracen-9-yl)methanimine
Acta Crystallographica Section E: Crystallographic Communications, 2017 The title compound, C25H20N2, (I), was synthesized from the condensation reaction of anthracene-9-carbaldehyde and tryptamine in dry ethanol. The indole ring system (r.m.s.
Md. Serajul Haque Faizi +3 more
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