Clinical Persistence of
mBio, 2019 Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which ...
Naraporn Somboonna +4 more
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Indole contributes to tetracycline resistance via the outer membrane protein OmpN in Vibrio splendidus [PDF]
, 2020 As an interspecies and interkingdom signaling molecule, indole has recently received attention for its diverse effects on the physiology of both bacteria and hosts. In this study, indole increased the tetracycline resistance of Vibrio splendidus.
Guo, Ming +6 more
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Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐Butoxide
ChemistryOpen, 2023 The indole moiety is an important N‐heterocycle found in natural products, and a key structural component of many value‐added chemicals including pharmaceuticals. In particular, bis(3‐indolyl)methanes (BIMs) are an important subgroup of indoles, composed
A. Sofia Santos +5 more
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Bisindolyl Maleimides and Indolylmaleimide Derivatives—A Review of Their Synthesis and Bioactivity
Pharmaceuticals, 2023 The evolution of bisindolyl maleimides and indolyl maleimide derivatives and their unique biological activities have stimulated great interest in medicinal chemistry programs.
Louise N. Cooney +5 more
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The Emergence of Insect Odorant Receptor-Based Biosensors
Biosensors, 2020 The olfactory receptor neurons of insects and vertebrates are gated by odorant receptor (OR) proteins of which several members have been shown to exhibit remarkable sensitivity and selectivity towards volatile organic compounds of significant importance ...
Jonathan D. Bohbot, Sefi Vernick
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Microorganisms, 2021 Gut microbiota metabolizes tryptophan into indole, which can influence brain and behavior. Indeed, some oxidized derivatives of indole, formed in the liver, have neuroactive properties, and indole overproduction by the gut microbiota induces an anxio ...
Catherine Philippe +8 more
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From sequence-defined macromolecules to macromolecular pin codes [PDF]
, 2020 Dynamic sequence-defined oligomers carrying a chemically written pin code are obtained through a strategy combining multicomponent reactions with the thermoreversible addition of 1,2,4-triazoline-3,5-diones (TADs) to indole substrates.
Badi, Nezha +4 more
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2-[3-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-8H-indeno[1,2-d]thiazole
IUCrData, 2019 The title molecule, C25H17ClFN3S, contains indenothiazolyl (A), pyrazolyl (B), fluorophenyl (C) and chlorophenyl (D) groups. The dihedral angles between the ring planes A/B, B/C and B/D are 14.2 (1), 83.0 (1) and 6.5 (2)°, respectively.
Gamal A. El-Hiti +4 more
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α-Glucosidase Inhibitors Based on Oleanolic Acid for the Treatment of Immunometabolic Disorders
Applied Sciences, 2023 Using oleanolic acid as a starting compound, a series of new oleanane-type triterpenic derivatives were synthesized via O-acylation (with nicotinic, isonicotinic, and methoxycinnamic acid acyl chlorides), N-amidation (with cyclic- or polyamines), the ...
Anastasiya V. Petrova +6 more
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Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies. [PDF]
, 2017 Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis.
Corsello, Michael A +2 more
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