Results 41 to 50 of about 134,351 (162)

Synthesis of benzothiophene and indole derivatives through metal-free propargyl–allene rearrangement and allyl migration

Beilstein Journal of Organic Chemistry, 2017
An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration.
Jinzhong Yao, Yajie Xie, Lianpeng Zhang, Yujin Li, Hongwei Zhou   +4 more
doaj   +1 more source

Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates

ChemistryOpen, 2023
A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives.
Shengnan Sun, Hexia Ye, Haibo Liu, Dr. Yongbiao Guo, Zhenhua Gao, Dr. Li Pan, Dr. Junchen Li, Prof. Dr. Xiaojing Bi   +7 more
doaj   +1 more source

NaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2015
Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media.
Mukut Gohani, Johannes H. van Tonder, Barend C.B. Benzuidenhoudt   +2 more
doaj  

Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I,
Fadi M. Awadallah, Silvia Bua, Walaa R. Mahmoud, Hossam H. Nada, Alessio Nocentini, Claudiu T. Supuran   +5 more
doaj   +1 more source

Escaping ESKAPE resistance: in vitro and in silico studies of multifunctional carbamimidoyl-tethered indoles against antibiotic-resistant bacteria

Royal Society Open Science, 2023
Combining the hybridization and repurposing strategies, six compounds from our in-house library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 were repurposed as potential antibacterial agents.
Kanika Gulia, Ahmed H. E. Hassan, Justin R. Lenhard, Abdelbasset A. Farahat   +3 more
doaj   +1 more source

Clinical Persistence of Chlamydia trachomatis Sexually Transmitted Strains Involves Novel Mutations in the Functional αββα Tetramer of the Tryptophan Synthase Operon

mBio, 2019
Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which ...
Naraporn Somboonna, Noa Ziklo, Thomas E. Ferrin, Jung Hyuk Suh, Deborah Dean   +4 more
doaj   +1 more source

Indole Treatment Alleviates Intestinal Tissue Damage Induced by Chicken Coccidiosis Through Activation of the Aryl Hydrocarbon Receptor

Frontiers in Immunology, 2019
Indoles, as the ligands of aryl hydrocarbon receptor (AhR), have been shown to possess immune-modulating property in terms of the balancing between regulatory T cells (Treg) and T helper 17 cells (Th17) activities.
Woo H. Kim, Hyun S. Lillehoj, Wongi Min
doaj   +1 more source

Novel Hybrid Indole-Based Caffeic Acid Amide Derivatives as Potent Free Radical Scavenging Agents: Rational Design, Synthesis, Spectroscopic Characterization, In Silico and In Vitro Investigations

Metabolites, 2023
Antioxidant small molecules can prevent or delay the oxidative damage caused by free radicals. Herein, a structure-based hybridization of two natural antioxidants (caffeic acid and melatonin) afforded a novel hybrid series of indole-based amide analogues
Ahmed Elkamhawy, Na Kyoung Oh, Noha A. Gouda, Magda H. Abdellattif, Saud O. Alshammari, Mohammed A. S. Abourehab, Qamar A. Alshammari, Amany Belal, Minkyoung Kim, Ahmed A. Al-Karmalawy, Kyeong Lee   +10 more
doaj   +1 more source

Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate

Molbank, 2023
Methyl 9-(1-methyl-1H-indol-3-yl)-9-oxononanoate was synthesized using Friedel–Crafts acylation between N-methyl indole and methyl 9-chloro-9-oxononanoate.
Gabriele Micheletti, Carla Boga
doaj   +1 more source

Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents

Molecules, 2023
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical resection of the tumor, radiotherapy, and adjuvant chemotherapy with ...
Silvia Salerno, Elisabetta Barresi, Emma Baglini, Valeria Poggetti, Federico Da Settimo, Sabrina Taliani   +5 more
doaj   +1 more source