2-(4-Fluorophenyl)-3-methyl-1H-indole [PDF]
, 2011 Funding: University of St Andrews and the Engineering and Physical Science Research Council (EPSRC, UK).The indole N-H hydrogen in the title compound, C15H12FN, does not display classical hydrogen bonding.
Woollins, J. Derek +7 more
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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Molecules, 2022 We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined.
Kailey A. Wyman +12 more
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Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives [PDF]
Archives of Biological Sciences, 2009 Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes ...
Daş-Evcimen N., Yildirim Ö., Suzen S.
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Indole-to-Carbazole Strategy for the Synthesis of Substituted Carbazoles under Metal-Free Conditions [PDF]
, 2016 An efficient indole-to-carbazole strategy has been developed under metal-free conditions. This carbazole formation was highly promoted by NH4I with high regioselectivity through formal [2 + 2 + 2] annulation of indoles, ketones, and nitroolefins. It thus
Penghui Ni (3204837) +4 more
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Catalyst-Controlled Regiodivergence in Rearrangements of Indole-Based Onium Ylides [PDF]
, 2021 We have developed catalyst-controlled regiodivergent rearrangements of onium-ylides derived from indole substrates. Oxonium ylides formed in situ from substituted indoles selectively undergo [2,3]- and [1,2]-rearrangements in the presence of a rhodium ...
Croix, Laconsay +4 more
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3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent [PDF]
, 2018 IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity.
Jeffrey K. Kerns (572412) +45 more
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Rhodium-Catalyzed NH-Indole-Directed C–H Carbonylation with Carbon Monoxide: Synthesis of 6H‑Isoindolo[2,1‑a]indol-6-ones [PDF]
, 2016 An efficient synthesis of 6H-isoindolo[2,1-a]indol-6-ones through rhodium-catalyzed NH-indole-directed C–H carbonylation of 2-arylindoles with carbon monoxide has been developed.
Lv Su (3359549) +7 more
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Beilstein Journal of Organic Chemistry, 2017 An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration.
Jinzhong Yao +4 more
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ChemistryOpen, 2023 A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives.
Shengnan Sun +7 more
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NaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2015 Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media.
Mukut Gohani +2 more
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