Results 41 to 50 of about 195,525 (279)
Molecules, 2022 A new synthetic alternative to the synthesis of 3-methyl indoles and 3-methyl indoline-2-ols with an excellent atomic economy is presented in this study.
Frank Hochberger-Roa +6 more
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Molecules, 2022 The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To examine their biological activity in the presence of the reference drug Donepezil (0.21 ± 0.12
Shoaib Khan +12 more
doaj +1 more source
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Molecules, 2022 We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined.
Kailey A. Wyman +12 more
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Electronic substitution effect on the ground and excited state properties of indole chromophore: A computational study [PDF]
, 2022 Indole, being the main chromophore of amino acid tryptophan and several other biologically relevant molecules like serotonin, melatonin, has prompted considerable theoretical and experimental interest.
Padmabati, Mondal, Soumyadip, Ray
core +2 more sources
Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives [PDF]
Archives of Biological Sciences, 2009 Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes ...
Daş-Evcimen N., Yildirim Ö., Suzen S.
doaj +1 more source
Marine Drugs, 2015 Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in ...
Netz, Natalie, Opatz, Till
openaire +4 more sources
Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase†
, 2016 Indole-2-carboxamide Inhibitors of Human Liver Glycogen Phosphorylase†
Dennis J. Hoover (1878532) +9 more
core +1 more source
Organocatalytic Enantioselective Nucleophilic Addition of Indole Imine 5-Methides [PDF]
, 2023 Despite the enormous developments in the asymmetric transformations of indole imine methides (IIMs), the remote asymmetric induction involving IIMs remains challenging due to the spatial interaction requirement between the substrate and catalyst.
Jianwei, Sun +5 more
core +2 more sources
New Approaches to Indoles and Indole Alkaloids [PDF]
Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings, 2013 Second only to pyridines, indoles are among the most common aromatic scaffolds present in bioactive molecules. The 5-hydroxy indole moiety alone has currently >10,500 substructure hits Among the many indole-containing alkaloid scaffolds, ergot alkaloids comprise a notable group of natural products of great biological activities. The striking biological
Peter Wipf, Filip Petronijevic
openaire +1 more source
Beilstein Journal of Organic Chemistry, 2017 An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration.
Jinzhong Yao +4 more
doaj +1 more source