Results 51 to 60 of about 195,525 (279)
ChemistryOpen, 2023 A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives.
Shengnan Sun +7 more
doaj +1 more source
, 2019 Five new indole-terpenoids named penerpenes E–I (1–5), along with seven known ones (6–12), were isolated from the marine-derived fungus Penicillium sp. KFD28 from a bivalve mollusk, Meretrix lusoria.
Jiu-Hui Li (4404250) +23 more
core +1 more source
CH activation and CH2 double activation of indolines: towards the synthesis of aspidospermidine and aspidofractinine [PDF]
, 2009 This thesis is concerned with the total synthesis of the two Aspidosperma alkaloid natural products, aspidospermidine and aspidofractinine. The two targets have a common pentacyclic molecular framework unique to this class of indole alkaloids ...
Whiting, Sally
core +1 more source
NaHSO4-SiO2: An Efficient Reusable Green Catalyst for Selective C-3 Propargylation of Indoles with Tertiary Propargylic Alcohols [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2015 Although several methods for the preparation of 4o propargyl indole derivatives have been published, this synthetic transformation is complicated by the tendency of 3o propargyl alcohols to form allenium intermediates in acidic media.
Mukut Gohani +2 more
doaj
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I,
Fadi M. Awadallah +5 more
doaj +1 more source
Royal Society Open Science, 2023 Combining the hybridization and repurposing strategies, six compounds from our in-house library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 were repurposed as potential antibacterial agents.
Kanika Gulia +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
mBio, 2019 Clinical persistence of Chlamydia trachomatis (Ct) sexually transmitted infections (STIs) is a major public health concern. In vitro persistence is known to develop through interferon gamma (IFN-γ) induction of indoleamine 2,3-dioxygenase (IDO), which ...
Naraporn Somboonna +4 more
doaj +1 more source
The benefits of indolence [PDF]
Communications of the ACM, 2019 The Communications Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of Communications , we'll publish selected posts or excerpts. twitter Follow us on Twitter at http://twitter ...
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source