Results 31 to 40 of about 134,351 (162)
Dialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted Indolenines
Molecules, 2019 2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natural ...
Tamie Suzuki +3 more
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Developing and Understanding Olfactory Evaluation of Boar Taint
Animals, 2020 Trained expert panels are used routinely in boar taint research, with varying protocols for training of panelists and scoring methods. We describe a standardized process for training and scoring, to contribute to standardize the olfactory detection of ...
Evert Heyrman +7 more
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Natural Product Reports, 2013 The natural product sesquiterpenyl indoles are structural hybrids from farnesyl pyrophosphate and tryptophan or its precursors, often with unusual and complex structural features, many of them with interesting biological activities. In this review the compounds of this class known until now are classified, a biosynthetic approach of each group is ...
Marcos, Isidro S. +4 more
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Molecules, 2022 A new synthetic alternative to the synthesis of 3-methyl indoles and 3-methyl indoline-2-ols with an excellent atomic economy is presented in this study.
Frank Hochberger-Roa +6 more
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Molecules, 2022 The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To examine their biological activity in the presence of the reference drug Donepezil (0.21 ± 0.12
Shoaib Khan +12 more
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Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Molecules, 2022 We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined.
Kailey A. Wyman +12 more
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Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives [PDF]
Archives of Biological Sciences, 2009 Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes ...
Daş-Evcimen N., Yildirim Ö., Suzen S.
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Marine Drugs, 2015 Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in ...
Netz, Natalie, Opatz, Till
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The benefits of indolence [PDF]
Communications of the ACM, 2019 The Communications Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of Communications , we'll publish selected posts or excerpts. twitter Follow us on Twitter at http://twitter ...
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New Approaches to Indoles and Indole Alkaloids [PDF]
Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings, 2013 Second only to pyridines, indoles are among the most common aromatic scaffolds present in bioactive molecules. The 5-hydroxy indole moiety alone has currently >10,500 substructure hits Among the many indole-containing alkaloid scaffolds, ergot alkaloids comprise a notable group of natural products of great biological activities. The striking biological
Peter Wipf, Filip Petronijevic
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