Results 31 to 40 of about 178,765 (288)

5-Benzoyl-2-(5-bromo-1H-indol-3-yl)-4-(4-nitrophenyl)-1H-pyrrole-3-carbonitrile dimethyl sulfoxide monosolvate

IUCrData, 2016
The title compound, C26H15BrN4O3·C2H6OS, contains five rings. The indole unit is essentially planar [maximum deviation = 0.0067 (1) Å for the N atom]. The central pyrrole ring makes dihedral angles of 44.1 (2) and 51.3 (2)° with the pendant indole ring ...
Y. AaminaNaaz, Jayabal Kamalraja, Paramasivam T. Perumal, A. SubbiahPandi   +3 more
doaj   +1 more source

Crystal structure of serotonin

Acta Crystallographica Section E: Crystallographic Communications, 2022
The title compound, serotonin or 5-hydroxytryptamine (5-HT) [systematic name: 3-(2-aminoethyl)-1H-indol-5-ol], C10H12N2O, has one molecule in the asymmetric unit. The conformation of the ethylamino side chain is gauche–gauche [Ca—Ca—Cm—Cm and Ca—Cm—Cm—N (
Marilyn Naeem, Andrew R. Chadeayne, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Dialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted Indolenines

Molecules, 2019
2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natural ...
Tamie Suzuki, Nilamber A. Mate, Arijit A. Adhikari, John D. Chisholm   +3 more
doaj   +1 more source

Developing and Understanding Olfactory Evaluation of Boar Taint

Animals, 2020
Trained expert panels are used routinely in boar taint research, with varying protocols for training of panelists and scoring methods. We describe a standardized process for training and scoring, to contribute to standardize the olfactory detection of ...
Evert Heyrman, Steven Janssens, Nadine Buys, Lynn Vanhaecke, Sam Millet, Frank A. M. Tuyttens, Jella Wauters, Marijke Aluwé   +7 more
doaj   +1 more source

The benefits of indolence [PDF]

Communications of the ACM, 2019
The Communications Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of Communications , we'll publish selected posts or excerpts. twitter Follow us on Twitter at http://twitter ...
openaire   +1 more source

Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment [PDF]

, 2006
Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D ...
L. H. Fox, Elena P. Moiseeva (7583435), Louise H. Fox (7583438), Margaret M. Manson (7583447), Lynne M. Howells (7583441), Louis A.F. Temple (7583444), L. M. Howells, E. P. Moiseeva, L. A. F. Temple, M. M. Manson   +9 more
core   +1 more source

Indole-containing arene-ruthenium complexes with broad spectrum activity against antibiotic-resistant bacteria [PDF]

, 2022
Antimicrobial resistant (AMR) bacteria are emerging and spreading globally, threatening our ability to treat common infectious diseases. The development of new classes of antibiotics able to kill or inhibit the growth of such AMR bacteria through novel ...
Malgorzata Wegrzyn (9382760), Maria Azmanova (18387291), Nicolas PE Barry (18387294), Anaïs Pitto-Barry (4600021), Danielle L Timms (18387282), Victoria C Nolan (18387276), Natalie Garton (13139580), Joan J Soldevila-Barreda (18387279), James Harrison (374971), Jonathan AG Cox (18387297), Helen Sendron (18387288), Marialuisa Crosatti (7666664), Colin C Seaton (18387285), Laia Rafols (9220509)   +13 more
core  

Interrupted Intramolecular Hydroaminomethylation of N-Protected-2-vinyl Anilines: Novel Access to 3-Substitued Indoles or Indoline-2-ols

Molecules, 2022
A new synthetic alternative to the synthesis of 3-methyl indoles and 3-methyl indoline-2-ols with an excellent atomic economy is presented in this study.
Frank Hochberger-Roa, Perla H. García-Ríos, José G. López-Cortés, M. Carmen Ortega-Alfaro, Jean-Claude Daran, Maryse Gouygou, Martine Urrutigoïty   +6 more
doaj   +1 more source

Indole-Containing Pyrazino[2,1b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids [PDF]

, 2022
Malaria, leishmaniasis, and sleeping sickness are potentially fatal diseases that represent a real health risk for more than 3,5 billion people. New antiparasitic compounds are urgent leading to a constant search for novel scaffolds.
Carla Carvalho, Anake Kijjoa, Emília Sousa (2177052), Denise Duarte, Diana I. S. P. Resende, Nuno Santarém, Artur M. S. Silva (7786178), Artur M. S. Silva, Solida Long, Anabela Cordeiro da Silva, Diana I. S. P. Resende (11934022), Anabela Cordeiro da Silva (11934025), Rafael Oliveira, Solida Long (11934016), Rui Moreira, Fátima Nogueira, Madalena M. M. Pinto, Andreia Palmeira, Rafael Oliveira (6619367), Emília Sousa, Denise Duarte (3835072), Madalena M. M. Pinto (7711166), Carla Carvalho (602417), Nuno Santarém (11934019), Anake Kijjoa (5175698), Rui Moreira (747231), Fátima Nogueira (1456960), Andreia Palmeira (450563)   +27 more
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Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase

Molecules, 2022
The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1–16) in which a number of reaction steps were involved. To examine their biological activity in the presence of the reference drug Donepezil (0.21 ± 0.12
Shoaib Khan, Shahid Iqbal, Muhammad Taha, Fazal Rahim, Mazloom Shah, Hayat Ullah, Ali Bahadur, Hamad Alrbyawi, Ayed A. Dera, Mohammed Issa Alahmdi, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk   +12 more
doaj   +1 more source