Results 101 to 110 of about 898,544 (258)

Characterization of acquired β-lactamases in Pseudomonas aeruginosa and quantification of their contributions to resistance

Microbiology Spectrum
Pseudomonas aeruginosa is a highly problematic opportunistic pathogen that causes a range of different infections. Infections are commonly treated with β-lactam antibiotics, including cephalosporins, monobactams, penicillins, and carbapenems, with ...
Karl A. Glen, Iain L. Lamont
doaj   +1 more source

Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)

Australian Veterinary Journal, EarlyView.
Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley   +1 more source

The Importance of Extended-Spectrum β-lactamases in Gram-Negative Enteric Bacilli and the Phenotypic Methods of detection [PDF]

Journal of Kerman University of Medical Sciences, 2016
The production of β-lactamase enzymes is the main mechanism of resistance to β-lactam antibiotics in gramnegative bacilli. Therefore, it is important to identify the β-lactamases-producing bacteria for the treatment of caused infections.
Davood Kalantar-Neyestanaki, Akbar Mirsalehian, Mohammad Eman eini, Fereshteh Jabalameli, Mehdi Fatahi-Bafghi, Shahla Mansouri   +5 more
doaj  

Purification of β-lactamases by chromatofocusing [PDF]

FEMS Microbiology Letters, 1983
Rolf G. Werner, Angelika M. Erne
openaire   +1 more source

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases [PDF]

, 2019
Breakdown of β-lactam antibiotics by β-lactamases is one of the most common resistance mechanisms against these drugs. Here, we present a computationally efficient combined quantum mechanics/molecular mechanics simulation protocol for hydrolysis of the β-
Viivi H. A. Hirvonen (6728288), Chudyk, Ewa, Mulholland, Adrian, Michael A. L. Limb (6728329), Adrian Mulholland (6439205), Ewa I. Chudyk (6728328), Hirvonen, Viivi, Spencer, James, Van der Kamp, Marc, Limb, Michael, James Spencer (6728327), Marc W. van der Kamp (6728324), Katharine Hammond (6728331), Hammond, Katharine   +13 more
core   +1 more source

Detection of zoonotic bacteria in wild Australian freshwater turtles

Australian Veterinary Journal, EarlyView.
Freshwater turtles are long‐lived, abundant components of Australian aquatic ecosystems, yet little is known about the diversity and prevalence of zoonotic bacteria they may carry. In this study, we conducted one of the most comprehensive surveys to date of zoonotic microorganisms associated with wild Australian freshwater turtles.
TF Scheelings, TTH Van, RJ Moore, LF Skerratt   +3 more
wiley   +1 more source

OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles

mBio
β-lactamases from Gram-negative bacteria are generally regarded as soluble, periplasmic enzymes. NDMs have been exceptionally characterized as lipoproteins anchored to the outer membrane. A bioinformatics study on all sequenced β-lactamases was performed
Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila   +6 more
doaj   +1 more source

Human metallo-β-lactamase enzymes degrade penicillin

Scientific Reports, 2019
Nonribosomal peptides are assemblages, including antibiotics, of canonical amino acids and other molecules. β-lactam antibiotics act on bacterial cell walls and can be cleaved by β-lactamases.
Seydina M. Diene, Lucile Pinault, Vivek Keshri, Nicholas Armstrong, Saber Khelaifia, Eric Chabrière, Gustavo Caetano-Anolles, Philippe Colson, Bernard La Scola, Jean-Marc Rolain, Pierre Pontarotti, Didier Raoult   +11 more
doaj   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

A retrospective analysis of bacterial pathogens in wounds in an equine hospital (2017–2022)

Equine Veterinary Education, EarlyView.
Summary Background Bacterial infections are a major cause of morbidity in horses, particularly in soft tissue wounds (STW) and surgical site infections (SSI). Rising antimicrobial resistance poses challenges for timely treatment. Knowledge of common pathogens and their resistance patterns is therefore essential.
J. Nebes, M. Schneeberger, S. Schmitt, J. N. van Spijk   +3 more
wiley   +1 more source