Results 71 to 80 of about 898,544 (258)
Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models. [PDF]
PLoS ONE, 2015 β-lactamase mediated antibiotic resistance is an important health issue and the discovery of new β-lactam type antibiotics or β-lactamase inhibitors is an area of intense research.
Hakime Öztürk +2 more
doaj +1 more source
BMEMat, EarlyView.LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng +4 more
wiley +1 more source
A review of SHV extended-spectrum β-lactamases: neglected yet ubiquitous
Frontiers in Microbiology, 2016 β-lactamases are the primary cause of resistance to β-lactams among members of the family Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections in health care in the last decades of the 20st century, and they are now ...
Apostolos Liakopoulos +3 more
doaj +1 more source
Investigation on some Beta- lactamase enzym types in Rhizobium leguminosarum biovar viciae [PDF]
مجلة التربية والعلم, 2009 Detection of β–lactamases was conducted in Rhizobium leguminosarum biovar viciae isolated from root nodules of Vicia faba L.. Acidimetric method was used to detect the occurrence of β–lactamases in general, the isolate gave a positive result.
Mohammed Ibrahem Altee +1 more
doaj +1 more source
Penetration of β-lactamase inhibitors into the periplasm of Gram-negative bacteria [PDF]
FEMS Microbiology Letters, 1999 The effectiveness of a beta-lactamase inhibitor/beta-lactam combination against Gram-negative pathogens depends on many interplaying factors, one of which is the penetration of the inhibitor across the outer membrane. In this work we have measured the relative penetrations of clavulanic acid, sulbactam, tazobactam and BRL 42715 into two strains of ...
Farmer TH, Degnan BA, Payne DJ
openaire +3 more sources
Probing the Role of Asn 152 in the Class C β-lactamase AmpC [PDF]
, 2012 AmpC, a class C β-lactamase, is a main cause of antibiotic resistance to cephalosporins in many species of bacteria. The current proposed mechanism of action involves an acyl-intermediate, where the enzyme becomes covalently attached to the drug at ...
Powers, Rachel +4 more
core
Clinical Pharmacology &Therapeutics, EarlyView.The intestinal microbiome is a key regulator of immune homeostasis, metabolism, and epithelial barrier integrity. In patients with malignant hematological diseases, particularly those undergoing hematopoietic stem cell transplantation, microbiome perturbations by reduced diversity, pathobiont expansion, and loss of beneficial metabolites are common as ...
Bálint Gergely Szabó +7 more
wiley +1 more source
Phenotypic detection of Metallo- and AmpC β-lactamases producing strains of P. aeruginosa in the state of Himachal Pradesh (India) [PDF]
Al Ameen Journal of Medical Sciences, 2015 Background: A prospective study was undertaken to detect metallo-β-lactamases (MBLs) and AmpC β-lactamases in Pseudomonas aeruginosa isolates recovered from patients at Indira Gandhi Medical College, Shimla (H.P).
Naveen Minhas, Prakash Chand Sharma
doaj
Detection of inducible β-lactamase by an agar dilution technique [PDF]
FEMS Microbiology Letters, 1985 An agar dilution technique for the detection of inducible β-lactamase-mediated resistance to the newer cephalosporins is described. Cefoxitin (16 μg/ml) was incorporated in agar plates together with cefamandole (8 μg/ml) or cefotaxime (8 μg/ml). The susceptibility of 35 strains of Enterobacter cloacae to these combinations was compared with their ...
openaire +1 more source
Cefotaxime-hydrolysing activity of the β-lactamase ofKlebsiella oxytocaD488 could be related to a threonine residue at position 140 [PDF]
FEMS Microbiology Letters, 1991 The chromosomally encoded β-lactamase of Klebsiella oxytoca D483 strain, active against all third-generation cephalosporins but ceftazidime, was purified to homogeneity. The pure protein was digested by trypsin, Staphylococcus aureus V8 protease or proteinase Asp-N.
Alain Reynaud +3 more
openaire +1 more source