Results 71 to 80 of about 729,044 (285)
, 2018 Table S1. List of the interactions between 7-ACA derivative, ceftriaxone and the residues in the binding pocket of the different TEM-1 β-lactamases from E. coli.
Annunziata Soriente (1566115) +5 more
core +1 more source
Editorial for the special issue: “targeting β- lactamases to fight bacterial resistance to β-Lactam antibiotics” [PDF]
, 2020 In bacteria, a major resistance mechanism to β-lactam antibiotics is the production of one or more β-lactamase enzymes. β-Lactamases belong to two structurally and mechanistically unrelated families of enzymes, serine-β-lactamases (SBLs; classes A, C ...
Cecilia Pozzi, Pozzi C.
core +1 more source
Frontiers in PharmacologyThe development of resistance to carbapenems in Klebsiella pneumoniae due to the production of metallo-β-lactamases (MBLs) is a critical public health problem because carbapenems are the last-resort drugs used for treating severe infections of extended ...
Wesam H. Abdulaal +14 more
doaj +1 more source
Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models. [PDF]
PLoS ONE, 2015 β-lactamase mediated antibiotic resistance is an important health issue and the discovery of new β-lactam type antibiotics or β-lactamase inhibitors is an area of intense research.
Hakime Öztürk +2 more
doaj +1 more source
The Role of Hydrophobic Nodes in the Dynamics of Class A β-Lactamases
Frontiers in Microbiology, 2021 Class A β-lactamases are known for being able to rapidly gain broad spectrum catalytic efficiency against most β-lactamase inhibitor combinations as a result of elusively minor point mutations.
Edgar Olehnovics +13 more
doaj +1 more source
Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden
ChemFoodChem, EarlyView.ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley +1 more source
An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases [PDF]
, 2019 Breakdown of β-lactam antibiotics by β-lactamases is one of the most common resistance mechanisms against these drugs. Here, we present a computationally efficient combined quantum mechanics/molecular mechanics simulation protocol for hydrolysis of the β-
Viivi H. A. Hirvonen (6728288) +13 more
core +1 more source
Investigation on some Beta- lactamase enzym types in Rhizobium leguminosarum biovar viciae [PDF]
مجلة التربية والعلم, 2009 Detection of β–lactamases was conducted in Rhizobium leguminosarum biovar viciae isolated from root nodules of Vicia faba L.. Acidimetric method was used to detect the occurrence of β–lactamases in general, the isolate gave a positive result.
Mohammed Ibrahem Altee +1 more
doaj +1 more source
, 2017 Additional file 3: Table S3. Antimicrobial typing of A. baumannii study isolates, showing individual isolates against commonly used drugs.
Raible, Kevin +6 more
openaire +1 more source
Antibacterial Activity of Heteropolytungstates Against Proteus mirabilis
European Journal of Inorganic Chemistry, EarlyView.We investigated the in vitro antibacterial activity of several heteropolytungstates against P. mirabilis, a drug‐resistant pathogen. All tested polyanions inhibited bacterial growth, with the Preyssler–Pope–Jeannin polyanion P5W30 exhibiting the highest activity (MIC = 0.78 mg/mL).
Nour El Ghouch +5 more
wiley +1 more source