Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis
Frontiers in Cellular and Infection Microbiology, 2023 Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis.
Chenchen Song +8 more
doaj +1 more source
Antimicrobial susceptibility patterns of β-lactamase producing <i>Staphylococcus Aureus</i>
Journal of Armed Forces Medical College, Bangladesh, 1970 doi:10.3329/jafmc.v4i2.1838JAFMC Bangladesh Vol.4(2) 2008 14 ...
Luthunnahar Khan +5 more
openaire +2 more sources
A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]
, 2018 Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI +5 more
core +2 more sources
Advanced Science, EarlyView.Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng +11 more
wiley +1 more source
Expression of β-lactamase inCoxiella burnetiitransformants [PDF]
FEMS Microbiology Letters, 2000 Coxiella burnetii can be transformed to ampicillin resistance by electroporation with plasmids encoding beta-lactamase. However, non-plasmid emergence of resistance to ampicillin also develops. To validate the usefulness of the bla gene marker for selection and detection, transformed C.
M L, Suhan, H A, Thompson
openaire +2 more sources
Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype [PDF]
, 2017 Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs).
Bordignon, Valentina +15 more
core +2 more sources
Advanced Science, EarlyView.Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin +12 more
wiley +1 more source
\u3cem\u3eArabidopsis thaliana\u3c/em\u3e GLX2-1 Contains a Dinuclear Metal Binding Site, but Is Not a Glyoxalase 2 [PDF]
, 2009 In an effort to probe the structure and function of a predicted mitochondrial glyoxalase 2, GLX2-1, from Arabidopsis thaliana, GLX2-1 was cloned, overexpressed, purified and characterized using metal analyses, kinetics, and UV–visible, EPR, and 1H-NMR ...
Bennett, Brian +3 more
core +2 more sources
Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing
Advanced Science, EarlyView.Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu +7 more
wiley +1 more source
Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions. [PDF]
PLoS ONE, 2012 Enzyme engineering has been facilitated by recombination of close homologues, followed by functional screening. In one such effort, chimeras of two class-A β-lactamases - TEM-1 and PSE-4 - were created according to structure-guided protein recombination ...
Christopher M Clouthier +7 more
doaj +1 more source