Results 51 to 60 of about 898,544 (258)

Smart Antibacterial Coatings: Harnessing Bacterial Redox Activity for Infection Control

Advanced Materials Interfaces, EarlyView.
In this study, we have shown that ceftazidime‐loaded poly(3,4‐ethylenedioxythiophene) (PEDOT@CAZ) functions as a smart, redox‐responsive antibacterial coating that couples bacterial electrical activity with localized antibiotic delivery. Shewanella oneidensis and Pseudomonas aeruginosa induced distinct redox responses in PEDOT, reflecting their ...
Abdullah, Szymon Smołka, Kamran Ayaz, Sara Shakibania, Sajida Maryam, Taral Patel, Roman Turczyn, Ewa Zabłocka‐Godlewska, Katarzyna Krukiewicz   +8 more
wiley   +1 more source

Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022

Emerging Infectious Diseases, 2023
Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health
Jennifer Lee, Subin Sunny, Elizabeth Nazarian, Mary Fornek, Marie Abdallah, Briana Episcopia, Marie-Claire Rowlinson, John Quale   +7 more
doaj   +1 more source

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Chimeric β-lactamases: global conservation of parental function and fast time-scale dynamics with increased slow motions. [PDF]

PLoS ONE, 2012
Enzyme engineering has been facilitated by recombination of close homologues, followed by functional screening. In one such effort, chimeras of two class-A β-lactamases - TEM-1 and PSE-4 - were created according to structure-guided protein recombination ...
Christopher M Clouthier, Sébastien Morin, Sophie M C Gobeil, Nicolas Doucet, Jonathan Blanchet, Elisabeth Nguyen, Stéphane M Gagné, Joelle N Pelletier   +7 more
doaj   +1 more source

MOESM3 of Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii

, 2017
Additional file 3: Table S3. Antimicrobial typing of A. baumannii study isolates, showing individual isolates against commonly used drugs.
Raible, Kevin, Bhaswati Sen, Law, Nancy, Bias, Tiffany, Emery, Christopher, Ehrlich, Garth, Joshi, Suresh   +6 more
openaire   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

MOESM1 of Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii

, 2017
Additional file 1: Table S1. Quality control (QC) organisms used in this study.
Raible, Kevin, Sen, Bhaswati, Law, Nancy, Bias, Tiffany, Emery, Christopher, Ehrlich, Garth, Joshi, Suresh   +6 more
openaire   +1 more source

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Expanding the β‐Lactamase Family in the Human Microbiome

Advanced Science
β‐lactams, the most common antibiotics globally, have resistance primarily determined by β‐lactamases. Human microbiota and β‐lactams influence mutually; however, β‐lactamase variety and abundance in the human microbiome remain partially understood. This
Baolei Jia, Ju Hye Baek, Jae Kyeong Lee, Ying Sun, Kyung Hyun Kim, Ji Young Jung, Che Ok Jeon   +6 more
doaj   +1 more source

Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases

, 2020
β-lactamase mediated antibiotic resistance threatens treatment of bacterial infections. OXA-48 enzymes are clinically important class D serine β-lactamases (SBLs) that confer resistance to most β-lactam antibiotics, including carbapenems. However, OXA-48
Viivi H. A. Hirvonen (6728288), Adrian Mulholland (6439205), James Spencer (6728327), Marc W. van der Kamp (6728324)   +3 more
core   +1 more source