Characterization of BAS-1, a novel class A β-lactamase encoded in Bacteroides thetaiotaomicron [PDF]
Antimicrobial Agents and ChemotherapyWe characterized a novel class A β-lactamase (BAS-1) in a pan-β-lactam-resistant Bacteroides thetaiotaomicron clinical isolate. Whole-genome sequencing identified blaBAS-1 within a mobile genetic element associated with IS4351.
María Aznar Fernández +4 more
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Rapid Typing of Extended‐Spectrum β‐Lactamase (ESBL)‐ and Metallo‐β‐Lactamase (MBL)‐Producing Enterobacterales Using Fourier Transform Infrared (FT‐IR) Spectroscopy [PDF]
MicrobiologyOpenThis study investigated the usefulness of the IR Biotyper, which types bacterial strains using Fourier transform infrared (FT‐IR) spectroscopy, against extended‐spectrum β‐lactamase (ESBL)‐ and metallo‐β‐lactamase (MBL)‐producing Enterobacterales.
Yasuhide Kawamoto +9 more
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Genetic Analysis of Virulence and β-Lactamase Determinants Related to β-Lactamase Inhibitors in Pseudomonas aeruginosa Strains from Nosocomial Infections [PDF]
AntibioticsBackground/Objectives: The emergence of hypervirulent Pseudomonas aeruginosa strains resistant to β-lactamase inhibitor antibiotics is a critical health problem as they impede the treatment of infections.
Gloria Luz Paniagua-Contreras +9 more
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NagX, a periplasmic β-N-acetylglucosaminidase, contributes to NagZ-independent β-lactamase expression in Stenotrophomonas maltophilia [PDF]
Antimicrobial Agents and ChemotherapyBeta-lactam resistance in Stenotrophomonas maltophilia is primarily mediated by the expression of L1 and L2 β-lactamases. L1/L2 expression is closely linked to peptidoglycan recycling through the AmpNG-NagZ-AmpR pathway, in which NagZ plays a dominant ...
En-Wei Hu +5 more
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Biochemical exploration of β-lactamase inhibitors
Frontiers in Genetics, 2023 The alarming rise of microbial resistance to antibiotics has severely limited the efficacy of current treatment options. The prevalence of β-lactamase enzymes is a significant contributor to the emergence of antibiotic resistance.
Varshaa Arer, Debasish Kar
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Frontiers in Microbiology, 2021 Objectives: Carbapenemase-producing organisms (CPOs) are associated with high mortality rates. The recent development of β-lactamase inhibitors (BLIs) has made it possible to control CPO infections safely and effectively with β-lactams (BLs).
Yanfang Feng +8 more
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A β-lactamase produced by a thermophilicBacillus [PDF]
FEMS Microbiology Letters, 1996 A β-lactamase was purified from a thermophilic Bacillus strain, that had been isolated from a traditional hot bath in the Meknes area (Morocco). The properties of the enzyme were very similar to those of the β-lactamase produced by Bacillus licheniformis 749C but it exhibited a somewhat increased thermostability and a higher activation energy with ...
Fouzia Rhazi-Filali +5 more
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TEM-E1: a novel β-lactamase conferring resistance to ceftazidime [PDF]
FEMS Microbiology Letters, 1989 A novel β-lactamase, conferring resistance to ceftazidime, has been identified to be encoded by a 31 kb plasmid (pUK720) in a clinical E. coli strain isolated in Belgium. The β-lactamase, new designated TEM-E1, has a pI of approximately 5.4 and lies in between the iso-electric focused bands of the β-lactamases TEM-1 and TEM-7.
D.J. Payne, M.S. Marriott, S.G.B. Amyes
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Identification and characterization of a novel β-lactamase TLE-2, encoded by plasmid pUK702 [PDF]
FEMS Microbiology Letters, 1987 A novel plasmid-mediated β-lactamase has been identified in a Klebsiella pneumoniae strain, carried by a plasmid pUK702. The pUK702 plasmid encodes TEM-1 and SHV-1 β-lactamase enzymes in addition to the novel enzyme. The novel enzyme has an Mr of 19 000 and a pI of 6.5. The enzyme is TEM-like in substrate profile and has been designated TLE-2 (TEM-like
Alison J. Reid +3 more
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PREVALENCE OF Β- LACTAMASE PRODUCING STAPHYLOCOCCUS AUREUS IN SLAUGHTERED [PDF]
Basrah Journal of Veterinary Research, 2008 Fifty liver and lung samples (25 for each) were examend for the presence of Staphylococcus aureus . The rate of S. aureus isolates were 60 and 56% in livers and lungs respectively. Identification of S.
Adnan M. AL- Rodhan
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