Results 31 to 40 of about 762,836 (292)

Mutation of serine residue 318 in the class C β-lactamase ofEnterobacter cloacae908R [PDF]

FEMS Microbiology Letters, 1992
The involvement of the serine residue 318 in the specificity of a class C β-lactamase was investigated. Multiple site-directed mutants at this position were generated using a polymerase chain reaction technique. These mutants were then probed for their activity towards various β-lactam compounds.
Christine Jacobs, Alain Dubus, Didier Monnaie, Staffan Normark, Jean-Marie Frère   +4 more
openaire   +1 more source

Induction of plasmid-mediated AmpC β-lactamase DHA-1 by piperacillin/tazobactam and other β-lactams in Enterobacteriaceae.

PLoS ONE, 2019
Chromosomal AmpC β-lactamase induction by several types of β-lactams has been reported, but not enough data are available on DHA-1 β-lactamase, a plasmid-mediated AmpC β-lactamase.
Kentaro Akata, Tetsuro Muratani, Kazuhiro Yatera, Keisuke Naito, Shingo Noguchi, Kei Yamasaki, Toshinori Kawanami, Takashi Kido, Hiroshi Mukae   +8 more
doaj   +1 more source

Isolation and preliminary characterization of β-lactamase excretory mutants ofEscherichia coliK-12 [PDF]

FEMS Microbiology Letters, 1984
Abstract Escherichia coli exc mutants able to release the plasmid pBR322-encoded β-lactamase (EC 3.5.2.6) into the extracellular medium have been isolated using a new in situ plate assay. A preliminary characterization of the exc mutants was carried out: the presence of exc mutations was associated with a specific or pleiotropic pattern of ...
Nicole Fognini-Lefebvre, Raymond Portalier   +1 more
openaire   +1 more source

Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing Escherichia coli in South Asia

, 2021
Aim: To determine the prevalence of extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and ...
Hassen Chowdhury, Mohammed Abdul, Naicker, Saiyuri, Roberts, Jason A, Islam, Kamrul, Henderson, Andrew, Heffernan, Aaron J, Sime, Fekade B   +6 more
core   +1 more source

Clinical Significance of Extended-spectrum β-lactamase-producing Bacteria in First Pediatric Febrile Urinary Tract Infections and Differences between Age Groups [PDF]

Childhood Kidney Diseases, 2017
Purpose Extended-spectrum β-lactamase-producing bacteria-induced urinary tract infections are increasing and require more potent antibiotics such as carbapenems.
Sun Yeong Park, Ji Hong Kim
doaj   +1 more source

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

Nature Communications, 2021
TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins.
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan   +7 more
doaj   +1 more source

In Vitro Susceptibility of Aztreonam-Vaborbactam, Aztreonam-Relebactam and Aztreonam-Avibactam Associations against Metallo-β-Lactamase-Producing Gram-Negative Bacteria

Antibiotics, 2023
Background: Despite the availability of new options (ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam and cefiderocol), it is still very difficult to treat infections caused by metallo-β-lactamase (MBLs)-producers resistant to aztreonam.
Cécile Emeraud, Sandrine Bernabeu, Laurent Dortet   +2 more
doaj   +1 more source

β-Lactamase is encoded on plasmid pACK3 inStaphylococcus simulansbiovarstaphylolyticus [PDF]

FEMS Microbiology Letters, 1991
Abstract Staphylococcus simulans biovar staphylolyticus , the lysostaphin-producing organism, contains five plasmids designated pACK1 through pACK5. Hybridization analysis using cloned β-lactamase gene ( bla ) as probe and characterization of cured strains revealed that bla resides on pACK3 rather than on the lysostaphin endopeptidase plasmid ...
Harry E. Heath, Lucie S. Heath, Karen E. Rose, Gary L. Sloan   +3 more
openaire   +1 more source

One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees [PDF]

, 2014
This work was supported by BBSRC (grant BB/F016778/1)Bacteria use metallo-β-lactamase enzymes to hydrolyse lactam rings found in many antibiotics, rendering them ineffective.
Barker, Daniel, Rosanna G. Alderson, John B. O. Mitchell, Daniel Barker, Alderson, Rosanna Grace, Alderson, Rosanna G, Mitchell, John B O, Mitchell, John B. O.   +7 more
core   +1 more source

Image_4_Exploring broilers and native fowls of Andaman and Nicobar Islands as a source of β-lactamase-producing Enterobacteriaceae even with limited anthropogenic activities and docking-based identification of catalytic domains in novel β-lactamase variants.JPEG

, 2023
ObjectivesThe present study was conducted to detect the occurrence of β-lactamase and biofilm-producing Escherichia coli, Salmonella, and Klebsiella in broilers and native fowl reared in the Andaman and Nicobar Islands, India.
Sneha Bhowmick (14330862), Tapan Kumar Dutta (14330880), Abhishek D. Singh (14330871), Siddhartha Narayan Joardar (14330874), Ananda Tiwari (7422383), Indranil Samanta (14330883), Surajit Pal (14330865), Kunal Batabyal (14330877), Jai Sunder (10119897), Samiran Bandyopadhyay (12880697), T. Sujatha (10119894), Tousif Mondal (14330868), Arun Kumar De (10119885)   +12 more
core   +1 more source