Results 1 to 10 of about 28,311 (167)
Novel monoclonal antibodies for immunodetection of AmpC β-lactamases [PDF]
PeerJBackground Accurate and easy-to-perform assays for the detection of antibiotic-resistant bacterial isolates producing AmpC β-lactamases are epidemiologically relevant, leading to more effective use of antibiotics and a comprehensive understanding of β ...
Karolina Bielskė +6 more
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Cooperative resistance varies among β-lactamases in E. coli, with some enabling cross-protection and sustained extracellular activity [PDF]
Communications Biologyβ-lactamases confer bacteria resistance to β-lactam antibiotics, and interestingly, this protective effect can extend to neighboring susceptible cells. However, knowledge of this cooperative resistance remains limited.
Qinqin Wang +2 more
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Antifungal agent tavaborole as a potential broad-spectrum serine and metallo-β-lactamases inhibitorResearch in context [PDF]
EBioMedicineSummary: Background: The global emergence and spread of carbapenem-resistant Enterobacteriaceae in clinical settings have driven the search for inhibitors that can counteract carbapenemases.
Yan Zhang +15 more
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RUHS Journal of Health Sciences, 2023 Introduction: Infections are the major cause of morbidity and mortality in burn patients. The ESBL, MBL and AmpC are the major mediators of antimicrobial resistance in gram negative bacteria. Early detection of ESBL, MBL and AmpC β -lactamases is crucial
Kusum Lata Lodha, Seema Surana
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A β-lactamase produced by a thermophilicBacillus [PDF]
FEMS Microbiology Letters, 1996 A β-lactamase was purified from a thermophilic Bacillus strain, that had been isolated from a traditional hot bath in the Meknes area (Morocco). The properties of the enzyme were very similar to those of the β-lactamase produced by Bacillus licheniformis 749C but it exhibited a somewhat increased thermostability and a higher activation energy with ...
Fouzia Rhazi-Filali +5 more
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Drug development concerning metallo-β-lactamases in gram-negative bacteria
Frontiers in Microbiology, 2022 β-Lactams have been a clinical focus since their emergence and indeed act as a powerful tool to combat severe bacterial infections, but their effectiveness is threatened by drug resistance in bacteria, primarily by the production of serine- and metallo-β-
Xiuyun Li +7 more
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TEM-E1: a novel β-lactamase conferring resistance to ceftazidime [PDF]
FEMS Microbiology Letters, 1989 A novel β-lactamase, conferring resistance to ceftazidime, has been identified to be encoded by a 31 kb plasmid (pUK720) in a clinical E. coli strain isolated in Belgium. The β-lactamase, new designated TEM-E1, has a pI of approximately 5.4 and lies in between the iso-electric focused bands of the β-lactamases TEM-1 and TEM-7.
D.J. Payne, M.S. Marriott, S.G.B. Amyes
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Genetics of Acquired Antibiotic Resistance Genes in Proteus spp.
Frontiers in Microbiology, 2020 Proteus spp. are commensal Enterobacterales of the human digestive tract. At the same time, P. mirabilis is commonly involved in urinary tract infections (UTI). P.
Delphine Girlich +11 more
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Identification and characterization of a novel β-lactamase TLE-2, encoded by plasmid pUK702 [PDF]
FEMS Microbiology Letters, 1987 A novel plasmid-mediated β-lactamase has been identified in a Klebsiella pneumoniae strain, carried by a plasmid pUK702. The pUK702 plasmid encodes TEM-1 and SHV-1 β-lactamase enzymes in addition to the novel enzyme. The novel enzyme has an Mr of 19 000 and a pI of 6.5. The enzyme is TEM-like in substrate profile and has been designated TLE-2 (TEM-like
Alison J. Reid +3 more
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Scientific Reports, 2021 New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria.
Azhar Salari-jazi +4 more
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