Results 21 to 30 of about 28,374 (228)

Isolation and preliminary characterization of β-lactamase excretory mutants ofEscherichia coliK-12 [PDF]

FEMS Microbiology Letters, 1984
Abstract Escherichia coli exc mutants able to release the plasmid pBR322-encoded β-lactamase (EC 3.5.2.6) into the extracellular medium have been isolated using a new in situ plate assay. A preliminary characterization of the exc mutants was carried out: the presence of exc mutations was associated with a specific or pleiotropic pattern of ...
Nicole Fognini-Lefebvre, Raymond Portalier   +1 more
openaire   +1 more source

Extended-spectrum β-lactamase Enterobacteriaceae from patients in Jeddah, Saudi Arabia: Antibiotic susceptibility and molecular approaches

Journal of Contemporary Medical Sciences, 2021
Objectives: This study aimed to determine the Enterobacteriaceae strains among patients who suffering diarrhea, phenotypic and genotypic characterization of ESBL-producing isolates in Jeddah, Saudi Arabia. Methods: Stool samples were collected and cultured to determine the different Enterobacteriaceae strains, PCR was done for the isolates to detect ...
Wafa A. Alshehri, Tarek A. A. Moussa
openaire   +2 more sources

β-Lactamase is encoded on plasmid pACK3 inStaphylococcus simulansbiovarstaphylolyticus [PDF]

FEMS Microbiology Letters, 1991
Abstract Staphylococcus simulans biovar staphylolyticus , the lysostaphin-producing organism, contains five plasmids designated pACK1 through pACK5. Hybridization analysis using cloned β-lactamase gene ( bla ) as probe and characterization of cured strains revealed that bla resides on pACK3 rather than on the lysostaphin endopeptidase plasmid ...
Harry E. Heath, Lucie S. Heath, Karen E. Rose, Gary L. Sloan   +3 more
openaire   +1 more source

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent

mBio, 2019
Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as ...
Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John O’Donnell, Joseph D. Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp-Wallace, Focco van den Akker, Robert A. Bonomo   +16 more
doaj   +1 more source

Acquired Class D β-Lactamases

Antibiotics, 2014
The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae.
Nuno T. Antunes, Jed F. Fisher
doaj   +1 more source

SUSCEPTIBILITY AND DETECTION OF EXTENDED SPECTRUM β-LACTAMASE ENZYMES FROM OTITIS MEDIA PATHOGENS [PDF]

American Journal of Infectious Diseases, 2013
Otitis media is the bacterial infection of the middle ear usually accompanied with inflammation, effusions and pain. It can present clinically in two major forms: Acute Otitis Media (AOM) and Otitis Media with Effusion (OME) and it is one of the leading cause of hospital visits and antibiotic prescriptions amongst children and even adults.
openaire   +1 more source

Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria

Memorias do Instituto Oswaldo Cruz, 2018
β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was
Melise Chaves Silveira, Marcos Catanho, Antônio Basílio de Miranda   +2 more
doaj   +1 more source

β-lactamases (bla TEM, bla SHV, bla CTXM-1, bla VEB, bla OXA-1) and class C β-lactamases gene frequency in Pseudomonas aeruginosa isolated from various clinical specimens in Khartoum State, Sudan: a cross sectional study [version 2; peer review: 2 approved]

F1000Research, 2020
Background: Pseudomonas aeruginosa is a pathogenic bacterium, causing nosocomial infections with intrinsic and acquired resistance mechanisms to a large group of antibiotics, including β-lactams.
Dina N. Abdelrahman, Aya A. Taha, Mazar M. Dafaallah, Alaa Abdelgafoor Mohammed, Abdel Rahim M. El Hussein, Ahmed I. Hashim, Yousif F. Hamedelnil, Hisham N. Altayb   +7 more
doaj   +1 more source

Could β-Lactam Antibiotics Block Humoral Immunity?

Frontiers in Immunology, 2021
It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination.
Cléa Melenotte, Cléa Melenotte, Pierre Pontarotti, Pierre Pontarotti, Pierre Pontarotti, Lucile Pinault, Lucile Pinault, Jean-Louis Mège, Jean-Louis Mège, Christian Devaux, Christian Devaux, Christian Devaux, Didier Raoult, Didier Raoult   +13 more
doaj   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, EarlyView.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources