LXA-1: a new plasmid-mediated β-lactamase giving low-level resistance [PDF]
LXA-1, a novel plasmid-mediated β-lactamase, was observed in clinical isolates of Klebsiella oxytoca, Klebsiella pneumoniae, Citrobacter freundii and Enterobacter cloacae. All the strains additionally produced TEM-1 β-lactamase. LXA-1 had an Mr of 24 000 and a pI of 6.7.
Youjun Yang, G.A. Jacoby, D.M. Livermore
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New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria.
Azhar Salari-jazi +4 more
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Virulence of non-β-lactamase-mediated ampicilin-resistantHaemophilus influenzae [PDF]
We questioned whether strains of ampicillin-resistant, non-β-lactamase-producing (AmpR NBLP) Haemophilus influenae with lower affinity penicillin-binding proteins (PBPs) might have altered virulence. The virulence of resistant transformant strains and the susceptible recipient was compared using infant rats. Following intraperitoneal inoculation, there
Lorry G. Rubin +3 more
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Identification and characterization of a novel β-lactamase TLE-2, encoded by plasmid pUK702 [PDF]
A novel plasmid-mediated β-lactamase has been identified in a Klebsiella pneumoniae strain, carried by a plasmid pUK702. The pUK702 plasmid encodes TEM-1 and SHV-1 β-lactamase enzymes in addition to the novel enzyme. The novel enzyme has an Mr of 19 000 and a pI of 6.5. The enzyme is TEM-like in substrate profile and has been designated TLE-2 (TEM-like
Alison J. Reid +3 more
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Investigation of beta-lactase enzymes in chromosomal bacilli isolated from diarrhea in children [PDF]
Thirty clinical isolates of gram negative bacilli isolated from diarrhea cases in children aged ≤5 years were investigated for the presence of β-lactamases, and it was found that 21 (70%) of them contain these enzymes.
Shaker Jarjees, Mahmoud Alleh
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Resistance of Some Bacteria Isolated from Urinary Tract Infections in Elderly Patients to Antibiotics and Detection of β-lactamases in Them [PDF]
Urinary tract infection is the second-largest infection, especially in elderly people, and the increasing use of antibiotics has led to the emergence and development of resistance in isolated and other bacteria in this study Fifty urine samples from ...
Mohammed Mahmood +2 more
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The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia [PDF]
Outer membrane vesicles (OMVs) are small nanoscale structures that are secreted by bacteria and that can carry nucleic acids, proteins, and small metabolites. They can mediate intracellular communication and play a role in virulence.
Bart eDevreese +9 more
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Molecular Characterization of AmpC β-lactamases in Enterobacteriaceae
AmpC β-lactamases are enzymes that are resistant to β-lactams, such as penicillin and cephalosporin, but not cefoxitin and cefotetan. This study was conducted to characterize AmpC β-lactamases in Enterobacteriaceae.
D. Bindu, Chitralekha Saikumar
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Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health [PDF]
Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present
Butaye, Patrick +7 more
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Pseudomonas aeruginosa can manipulate eukaryotic host cells using secreted effectors delivered by the type III or the type VI Secretion Systems (T3SS and T6SS). The T3SS allows the injection of bacterial effectors (Exo toxins) into eukaryotic cell.
Thibaud Boulant +10 more
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