Results 41 to 50 of about 898,544 (258)
Microbiome, 2017 Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and ...
Fanny Berglund +7 more
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Some aspects of general characteristic and classification of bacterial β-lactamases
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2009 Main structural and functional groups of bacterial β-lactamases are cited in the data review. Modern systems of classification, which was based on spectra of activity, sensitivity to inhibitors and peculiarities of molecular structure are described.
A. V. Krysenko +2 more
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Fungal Lactamases: Their Occurrence and Function
Frontiers in Microbiology, 2017 Fungi are absorptive feeders and thus must colonize and ramify through their substrate to survive. In so doing they are in competition, particularly in the soil, with myriad microbes.
Minglu Gao +3 more
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Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
, 2019 The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1 and ...
Philip Hinchliffe (1483897) +12 more
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, 2021 Class D β-lactamases are composed of 14 families and the majority of the member enzymes are included in the OXA family. The genes for class D β-lactamases are frequently identified in the chromosome as an intrinsic resistance determinant in environmental
정석훈
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Advanced Functional Materials, EarlyView.A dynamically actuated reconfigurable topographical surface (DARTS) integrates contact‐mediated bactericidal nanotopography with programmable mechanical actuation to actively disrupt bacterial biofilms. Dynamic surface reconfiguration enhances bacterial killing and suppresses implant‐associated infections in vivo, providing a new strategy for active ...
Mohammad Asadi Tokmedash +4 more
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Environmental species from theTelluria group as the putative origin of bifunctionalβ-lactamases
Microbiology Spectrumβ-Lactamases comprise two structurally and evolutionarily well-defined groups: serine- (SBL) and metallo-β-lactamases (MBL). To date, clinically relevant β-lactamases are typically monofunctional DD-peptidases, containing a single active site cavity per ...
Pedro Penzotti +3 more
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Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis
Frontiers in Cellular and Infection Microbiology, 2023 Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis.
Chenchen Song +8 more
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Expression of β-lactamase inCoxiella burnetiitransformants [PDF]
FEMS Microbiology Letters, 2000 Coxiella burnetii can be transformed to ampicillin resistance by electroporation with plasmids encoding beta-lactamase. However, non-plasmid emergence of resistance to ampicillin also develops. To validate the usefulness of the bla gene marker for selection and detection, transformed C.
M L, Suhan, H A, Thompson
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β-Lactamases: quality and resistance [PDF]
, 1997 β-Lactamase-mediated resistance to β-lactam antibiotics is a feature of great clinical significance. β-Lactamases are a diverse group of bacterial enzymes that vary in their abilities to hydrolyze β-lactam antibiotics. β-Lactamases possess an active site
Medeiros, Antone A.
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