Results 1 to 10 of about 9,673 (155)

Drug development concerning metallo-β-lactamases in gram-negative bacteria [PDF]

Frontiers in Microbiology, 2022
β-Lactams have been a clinical focus since their emergence and indeed act as a powerful tool to combat severe bacterial infections, but their effectiveness is threatened by drug resistance in bacteria, primarily by the production of serine- and metallo-β-
Hefeng Wang
exaly   +4 more sources

Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution

Antibiotics, 2014
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able
Maria-Rocío Meini, Leticia I Llarrull, Alejandro J Vila   +2 more
exaly   +3 more sources

Antifungal agent tavaborole as a potential broad-spectrum serine and metallo-β-lactamases inhibitorResearch in context [PDF]

EBioMedicine
Summary: Background: The global emergence and spread of carbapenem-resistant Enterobacteriaceae in clinical settings have driven the search for inhibitors that can counteract carbapenemases.
Yan Zhang, Siyuan Yang, Zhaoju Deng, Huangwei Song, Ning Xie, Yunrui Tian, Shangshang Qin, Jifeng Liu, Yong Guo, Dongli Wang, Junfeng Liu, Congming Wu, Jianzhong Shen, Shizhen Ma, Yang Wang, Dejun Liu   +15 more
doaj   +2 more sources

Specific Protein-Membrane Interactions Promote Packaging of Metallo-β-Lactamases into Outer Membrane Vesicles [PDF]

Antimicrobial Agents and Chemotherapy, 2021
Carolina Lopez, Alessio Prunotto, Guillermo Bahr   +2 more
exaly   +2 more sources

Discovery of potential inhibitors against New Delhi metallo-β-lactamase-1 from natural compounds: in silico-based methods

Scientific Reports, 2021
New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria.
Azhar Salari-jazi, Karim Mahnam, Parisa Sadeghi, Mohamad Sadegh Damavandi, Jamshid Faghri   +4 more
doaj   +1 more source

Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022

Emerging Infectious Diseases, 2023
Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health
Jennifer Lee, Subin Sunny, Elizabeth Nazarian, Mary Fornek, Marie Abdallah, Briana Episcopia, Marie-Claire Rowlinson, John Quale   +7 more
doaj   +1 more source

Faropenem reacts with serine and metallo-β-lactamases to give multiple products [PDF]

European Journal of Medicinal Chemistry, 2021
Philip Hinchliffe, Tika R Malla, Catherine L Tooke   +2 more
exaly   +2 more sources

Could β-Lactam Antibiotics Block Humoral Immunity?

Frontiers in Immunology, 2021
It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination.
Cléa Melenotte, Cléa Melenotte, Pierre Pontarotti, Pierre Pontarotti, Pierre Pontarotti, Lucile Pinault, Lucile Pinault, Jean-Louis Mège, Jean-Louis Mège, Christian Devaux, Christian Devaux, Christian Devaux, Didier Raoult, Didier Raoult   +13 more
doaj   +1 more source

Prevalence of Extended Spectrum β-Lactamase, Metallo β-Lactamase, and AmpC β-Lactamase among Gram Negative Bacilli Recovered from Burn Wound Infection

RUHS Journal of Health Sciences, 2023
Introduction: Infections are the major cause of morbidity and mortality in burn patients. The ESBL, MBL and AmpC are the major mediators of antimicrobial resistance in gram negative bacteria. Early detection of ESBL, MBL and AmpC β -lactamases is crucial
Kusum Lata Lodha, Seema Surana
doaj   +1 more source

Taxifolin as a Metallo-β-Lactamase Inhibitor in Combination with Augmentin against Verona Imipenemase 2 Expressing Pseudomonas aeruginosa

Microorganisms, 2023
Among the various mechanisms that bacteria use to develop antibiotic resistance, the multiple expression of β-lactamases is particularly problematic, threatening public health and increasing patient mortality rates. Even if a combination therapy—in which
Bogdan M. Benin, Trae Hillyer, Aylin S. Crugnale, Andrew Fulk, Caitlyn A. Thomas, Michael W. Crowder, Matthew A. Smith, Woo Shik Shin   +7 more
doaj   +1 more source