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BMC Research Notes, 2017 Objectives This study was carried out to determine the prevalence of metallo-β-lactamases (MBLs) producing Pseudomonas aeruginosa in imipenem-nonsusceptible isolates and to detect MBL-encoding genes among MBLs-positive isolates.
Mahesh Acharya +5 more
doaj +2 more sources
OXA-carbapenemases present in clinical acinetobacter baumannii-calcoaceticus complex isolates from patients in kurdistan region, Iraq [PDF]
, 2016 In addition to intrinsic resistance in Acinetobacter baumannii, many different types of acquired resistance mechanisms have been reported, including the presence of VIM and IMP metallo β-lactamases and also of blaOXA-23-like and blaOXA-58-like enzymes ...
Alnakshabandi, A.A. +12 more
core +4 more sources
Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
Nature Communications, 2018 Metallo-β-lactamases (MBL) are zinc containing enzymes that cause resistance to β-lactam antibiotics. Here the authors show that the anti-Helicobacter pylori drug colloidal bismuth subcitrate inhibits MBLs by displacing the zinc ions with Bi(III), which ...
Runming Wang +9 more
doaj +1 more source
Detection of VIM-1 and IMP-1 genes in Klebsiella pneumoniae and relationship with biofilm formation [PDF]
, 2018 Klebsiella pneumoniae is an important human pathogen that is considered in recent years due to nosocomial infections resistant to treatment as well as the ability to form biofilms particularly in patients with urinary tract infection in ICU or hospital ...
Javadi, A. +4 more
core +1 more source
Microbiology SpectrumNew β-lactam–β-lactamase inhibitor combinations represent last-resort antibiotics to treat infections caused by multidrug-resistant Pseudomonas aeruginosa.
Felice Valzano +11 more
doaj +1 more source
Cloning, Expression And Characterization Of Ahlinactivating aiiA Gene Homologue In Escherichia coli [PDF]
, 2014 Cell-to-cell communication pathway of single-celled microbes is usually coordinated by quorum sensing (QS) system mediated by signal molecules. This cell density-dependent system plays a vital role in functional coordination of most pathogenic ...
Subashini, Muniandy
core
"Golden Era of Antibiotics" - Coming to an end !!!
SRM Journal of Research in Dental Sciences, 2012 Resistance to antibiotics is increasing at an alarming rate. This is due to superbugs, producing heterogenous groups of enzymes, β-lactamases which inactivate β-lactam antibiotics and others as well.
V Vinodhini +4 more
doaj
Nature Communications, 2017 New Delhi metallo-β-lactamases (NDMs) hydrolyze almost all β-lactam antibiotics and pose a major public health threat. Here, the authors study the mechanism of NDM-1 catalyzed carbapenem hydrolysis and present the crystal structures of the enzyme ...
Han Feng +5 more
doaj +1 more source
Reappraisal of hospital-acquired pneumonia mortality in the era of metallo-β-lactamase-mediated multidrug resistance: a prospective observational study [PDF]
, 2006 Introduction Hospital-acquired pneumonia (HAP) due to Pseudomonas aeruginosa is associated with high mortality rates. The metallo-β-lactamases (MBLs) are emerging enzymes that hydrolyze virtually all β-lactams. We aimed to assess P.
Barth, Afonso Luis +5 more
core +1 more source
Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism
Biomolecules, 2020 β-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum. Their action is counteracted by different resistance mechanisms developed by bacteria.
Antonela R. Palacios +3 more
doaj +1 more source