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Evolution of Metallo-β-lactamases: Trends Revealed by Natural Diversity and in vitro Evolution [PDF]

Antibiotics, 2014
The production of β-lactamase enzymes is one of the most distributed resistance mechanisms towards β-lactam antibiotics. Metallo-β-lactamases constitute a worrisome group of these kinds of enzymes, since they present a broad spectrum profile, being able
Leticia Llarrull, Alejandro Vila, Maria-Rocío Meini   +2 more
exaly   +4 more sources

Drug development concerning metallo-β-lactamases in gram-negative bacteria [PDF]

Frontiers in Microbiology, 2022
β-Lactams have been a clinical focus since their emergence and indeed act as a powerful tool to combat severe bacterial infections, but their effectiveness is threatened by drug resistance in bacteria, primarily by the production of serine- and metallo-β-
Xiuyun Li, Jing Zhao, Bin Zhang, Xuexia Duan, Jin Jiao, Weiwei Wu, Yuxia Zhou, Hefeng Wang   +7 more
doaj   +2 more sources

Dynamically chiral phosphonic acid-type metallo-β-lactamase inhibitors

Communications Chemistry
Antibiotic resistance is a growing global health threat that risks the lives of millions. Among the resistance mechanisms, that mediated by metallo-β-lactamases is of particular concern as these bacterial enzymes dismantle most β-lactam antibiotics ...
Kinga Virág Gulyás, Liping Zhou, Daniel Salamonsen, Andreas Prester, Kim Bartels, Robert Bosman, Paul Haffke, Jintian Li, Viola Tamási, Fritz Deufel, Johannes Thoma, Anna Andersson Rasmussen, Miklós Csala, Hanna-Kirsti Schroder Leiros, Zhijian Xu, Mikael Widersten, Holger Rohde, Eike C. Schulz, Weiliang Zhu, Máté Erdélyi   +19 more
doaj   +6 more sources

Antifungal agent tavaborole as a potential broad-spectrum serine and metallo-β-lactamases inhibitorResearch in context [PDF]

EBioMedicine
Summary: Background: The global emergence and spread of carbapenem-resistant Enterobacteriaceae in clinical settings have driven the search for inhibitors that can counteract carbapenemases.
Yan Zhang, Siyuan Yang, Zhaoju Deng, Huangwei Song, Ning Xie, Yunrui Tian, Shangshang Qin, Jifeng Liu, Yong Guo, Dongli Wang, Junfeng Liu, Congming Wu, Jianzhong Shen, Shizhen Ma, Yang Wang, Dejun Liu   +15 more
doaj   +2 more sources

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2 [PDF]

Antibiotics, 2022
Jürgen Brem, Christopher Schofield, James Spencer   +2 more
exaly   +2 more sources

Discovery of potential inhibitors against New Delhi metallo-β-lactamase-1 from natural compounds: in silico-based methods

Scientific Reports, 2021
New Delhi metallo-β-lactamase variants and different types of metallo-β-lactamases have attracted enormous consideration for hydrolyzing almost all β-lactam antibiotics, which leads to multi drug resistance bacteria.
Azhar Salari-jazi, Karim Mahnam, Parisa Sadeghi, Mohamad Sadegh Damavandi, Jamshid Faghri   +4 more
doaj   +1 more source

Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016–2022

Emerging Infectious Diseases, 2023
Controlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health
Jennifer Lee, Subin Sunny, Elizabeth Nazarian, Mary Fornek, Marie Abdallah, Briana Episcopia, Marie-Claire Rowlinson, John Quale   +7 more
doaj   +1 more source

Novel metallo β-lactamase mediated by aShigella flexneriplasmid [PDF]

FEMS Microbiology Letters, 1998
Novel carbapenem-hydrolyzing beta-lactamase (newly named MET-1) encoded on a transferable plasmid pMS390 from Shigella flexneri JS19622 was purified. The molecular weight was 28,000 by SDS-PAGE and the isoelectric point was higher than 9.3. This beta-lactamase favorably hydrolyzed classical cephalosporins and oxyimino-cephalosporins rather than ...
K, O'Hara, S, Haruta, T, Sawai, M, Tsunoda, S, Iyobe   +4 more
openaire   +2 more sources

Could β-Lactam Antibiotics Block Humoral Immunity?

Frontiers in Immunology, 2021
It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination.
Cléa Melenotte, Cléa Melenotte, Pierre Pontarotti, Pierre Pontarotti, Pierre Pontarotti, Lucile Pinault, Lucile Pinault, Jean-Louis Mège, Jean-Louis Mège, Christian Devaux, Christian Devaux, Christian Devaux, Didier Raoult, Didier Raoult   +13 more
doaj   +1 more source

Prevalence of Extended Spectrum β-Lactamase, Metallo β-Lactamase, and AmpC β-Lactamase among Gram Negative Bacilli Recovered from Burn Wound Infection

RUHS Journal of Health Sciences, 2023
Introduction: Infections are the major cause of morbidity and mortality in burn patients. The ESBL, MBL and AmpC are the major mediators of antimicrobial resistance in gram negative bacteria. Early detection of ESBL, MBL and AmpC β -lactamases is crucial
Kusum Lata Lodha, Seema Surana
doaj   +1 more source