Results 41 to 50 of about 893,574 (181)

Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters

, 2022
Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remaincontrary to earlier predictionsa major consideration for the public health of the 21st century. Resistance development of
Hanna Andersson (1408987), Linus Sandegren (12066), Manuela Vorácová (11998639), Anna Andersson Rasmussen (11998645), Lisa Allander (11998648), Susann Skagseth (11998642), Katarzyna Palica (11998636), Madlen Hubert (1963375), Hanna-Kirstirep Schrøder Leiros (11998651), Máté Erdélyi (1364241)   +9 more
core   +1 more source

Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria

Frontiers in Microbiology, 2022
Ceftazidime-avibactam is one of the last resort antimicrobial agents for the treatment of carbapenem-resistant, Gram-negative bacteria. Metallo-β-lactamase-producing bacteria are considered to be ceftazidime-avibactam resistant. Here, we evaluated a semi-
Michaela Simon, Michaela Simon, Roman G. Gerlach, Yvonne Pfeifer, Niels Pfennigwerth, Sören G. Gatermann, Agnes Schröder, Agnes Schröder, Andreas Hiergeist, Axel Hamprecht, Axel Hamprecht, Axel Hamprecht, Axel Hamprecht, Tamara Rügamer, André Gessner, Jonathan Jantsch, Jonathan Jantsch   +16 more
doaj   +1 more source

Additional file 1: of Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool

, 2019
Definitions and sources of sepsis. (DOCX 17 kb)
Persoon, Marjolein, Voor in ‘t holt, Anne, Meer, Maurits, Bokhoven, Karen, Gommers, Diederik, Vos, Margreet, Severin, JuliĂŤtte   +6 more
openaire   +1 more source

Profiling interactions of vaborbactam with metallo-β-lactamases [PDF]

, 2019
β-Lactams are the most successful antibacterials, yet their use is threatened by resistance, importantly as caused by β-lactamases. β-Lactamases fall into two mechanistic groups: the serine β-lactamases that utilise a covalent acyl-enzyme mechanism and ...
Cain, Ricky, Calvopiña, K, Widlake, E, Langley, Gareth W., Langley, GW, Hinchliffe, Philip, Walsh, TR, Brem, Jürgen, Tooke, CL, Hinchliffe, P, Tyrrell, Jonathan M., Walsh, Timothy R., Tooke, Catherine L., Cain, R, Spencer, J, Brem, J, Widlake, Emma, Calvopiña, Karina, Dowson, Christopher G., Dowson, CG, Tyrrell, JM, Spencer, James, Schofield, Christopher J., Schofield, CJ, Schofield, Christopher   +24 more
core   +3 more sources

Prediction of Phytochemicals for Their Potential to Inhibit New Delhi Metallo β-Lactamase (NDM-1)

Pharmaceuticals, 2023
The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme.
Zainab Bibi, Irfa Asghar, Naeem Mahmood Ashraf, Iftikhar Zeb, Umer Rashid, Arslan Hamid, Maria Kanwal Ali, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Raza Ahmad, Muhammad Ali   +10 more
doaj   +1 more source

Additional file 3: of Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool

, 2019
Clinical review form. (DOCX 24 kb)
Persoon, Marjolein, Voor in ‘t holt, Anne, Meer, Maurits, Bokhoven, Karen, Gommers, Diederik, Vos, Margreet, Severin, JuliĂŤtte   +6 more
openaire   +1 more source

ENTEROBACTERIACAE, PRODUCING ESBLS AND METALLO-β-LACTAMASE NDM-1, ISOLATED IN HOSPITALS OF BALTIC REGION COUNTRIES

Инфекция и иммунитет, 2014
. We studied the prevalence of K. pneumoniae and E. coli resistance to extended spectrum cephalosporins and carbapenems, isolated from patients of eight hospitals in St-Petersburg from January to May, 2012.
S. A. Egorova, L. A. Kaftyreva, L. V. Lipskaya, I. B. Konovalenko, M. F. Pyasetskaya, T. S. Kurchikova, N. B. Vedernikova, O. T. Morozova, M. V. Smirnova, L. N. Popenko, M. I. Lubushkina, J. A. Savochkina, M. A. Makarova, L. V. Suzhaeva, J. V. Ostankova, M. N. Ivanova, A. M. Pavelkovich, P. Naaber, E. Sepp, S. Kõljalg, J. Miciuleviciene, A. Balode   +21 more
doaj   +1 more source

β-lactamase-mediated resistance in MDR-Pseudomonas aeruginosa from Qatar

Antimicrobial Resistance and Infection Control, 2020
Background The distribution of β-lactam resistance genes in P. aeruginosa is often closely related to the distribution of certain high-risk international clones.
Mazen A. Sid Ahmed, Faisal Ahmad Khan, Ali A. Sultan, Bo Söderquist, Emad Bashir Ibrahim, Jana Jass, Ali S. Omrani   +6 more
doaj   +1 more source

Additional file 1: Table S1. of Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

, 2017
Worldwide distribution of NDM producing bacteria, as per articles available on PubMed database in the time period of Dec 2013 to Feb 2017. (PDF 136 kb)
Khan, Asad, Maryam, Lubna, Zarrilli, Raffaele   +2 more
openaire   +1 more source

Procedure of the overexpression, purification and crystallization of BLEG-1, a bifunctional and evolutionary divergent B3 metallo-β-lactamase, for structure-function studies

MethodsX, 2022
Metallo-β-lactamases (MBLs) are class B β-lactamases from the metallo-hydrolase-like MBL-fold superfamily which act on a broad range of β-lactam antibiotics, thus conferring antibiotics resistance to bacterial pathogens.
Shaw Xian Au, Noor Dina Muhd Noor, Hiroyoshi Matsumura, Raja Noor Zaliha Raja Abdul Rahman, Yahaya M. Normi   +4 more
doaj   +1 more source