Results 41 to 50 of about 9,673 (155)

β-Lactam Antibiotics and β-Lactamase Enzymes Inhibitors, Part 2: Our Limited Resources

Pharmaceuticals, 2022
β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the increasing emergence of resistance to them, developed by bacteria producing β-lactamase enzymes (BLEs), is becoming one of the major warnings to the global public health.
Silvana Alfei, Anna Maria Schito
doaj   +1 more source

Additional file 1: of Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool

, 2019
Definitions and sources of sepsis. (DOCX 17 kb)
Persoon, Marjolein, Voor in ‘t holt, Anne, Meer, Maurits, Bokhoven, Karen, Gommers, Diederik, Vos, Margreet, Severin, JuliĂŤtte   +6 more
openaire   +1 more source

Additional file 3: of Mortality related to Verona Integron-encoded Metallo-β-lactamase-positive Pseudomonas aeruginosa: assessment by a novel clinical tool

, 2019
Clinical review form. (DOCX 24 kb)
Persoon, Marjolein, Voor in ‘t holt, Anne, Meer, Maurits, Bokhoven, Karen, Gommers, Diederik, Vos, Margreet, Severin, JuliĂŤtte   +6 more
openaire   +1 more source

Additional file 1: Table S1. of Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

, 2017
Worldwide distribution of NDM producing bacteria, as per articles available on PubMed database in the time period of Dec 2013 to Feb 2017. (PDF 136 kb)
Khan, Asad, Maryam, Lubna, Zarrilli, Raffaele   +2 more
openaire   +1 more source

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

MOESM5 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 5: Table S4. Potential Virulence factors identified in the Chryseobacterium indologenes J31 genome.
Wang, Tingting, Jiang, Xiawei, Feng, Chunyan, Li, Ang, Dong, Huihui, Wu, Shaoqiang, Zheng, Beiwen   +6 more
openaire   +1 more source

Functional dynamics of water in New Delhi metallo‐β‐lactamase catalysis

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Water plays a critical role in the hydrolysis of antibiotics by New Delhi metallo‐β‐lactamases (NDMs). The reaction proceeds through a nucleophilic attack on the β‐lactam ring, followed by cleavage of the C–N bond and formation of an anionic nitrogen intermediate. This intermediate is then protonated by a water molecule diffusing from the bulk
Palanisamy Kandhan, Chuanye Xiong, Timothy Palzkill, Peng Tao   +3 more
wiley   +1 more source

MOESM6 of Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

, 2016
Additional files 6: Table S5. Four conjugative transposon gene clusters in the Chryseobacterium indologenes J31 genome.
Tingting Wang, Xiawei Jiang, Chunyan Feng, Li, Ang, Huihui Dong, Shaoqiang Wu, Beiwen Zheng   +6 more
openaire   +1 more source

Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis

Frontiers in Cellular and Infection Microbiology, 2023
Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis.
Chenchen Song, Xuan Sun, Xuan Sun, Yao Wang, Leif Bülow, Michael Mecklenburg, Changxin Wu, Qinglai Meng, Bin Xie   +8 more
doaj   +1 more source

Zwitterionic Penicillin‐Derived Sulfone Inhibitor for Combating β‐Lactamase‐Mediated Antibiotic Resistance

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Diana Rodríguez, Emilio Lence, Juan C. Vázquez‐Ucha, Alejandro Beceiro, Concepción González‐Bello   +4 more
wiley   +1 more source