Results 61 to 70 of about 9,732 (155)

Phenotypic detection of Metallo- and AmpC β-lactamases producing strains of P. aeruginosa in the state of Himachal Pradesh (India) [PDF]

Al Ameen Journal of Medical Sciences, 2015
Background: A prospective study was undertaken to detect metallo-β-lactamases (MBLs) and AmpC β-lactamases in Pseudomonas aeruginosa isolates recovered from patients at Indira Gandhi Medical College, Shimla (H.P).
Naveen Minhas, Prakash Chand Sharma
doaj  

Genomic Insights Into Antimicrobial Resistance and Virulence of Enterococcus avium Strains From Bovine Mastitis in Some Selected Dairy Farms of Bangladesh

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
The graphical abstract outlines that samples from milk, faeces and soil were tested for Enterococcus avium using culture, PCR and genome sequencing.2. Overall, prevalence of E. avium was 56.3%, and 93.5% of isolates were multidrug‐resistant.3. Genomic analysis revealed six ARGs, 43–45 VFGs and 4–6 bacteriocins.4.
Monira Rahaman, Md. Morshedur Rahman, Kh. Yeashir Arafat, Md. Abu Ahsan Gilman, Naim Siddique, Taniya Sultana, Ziban Chandra Das, Anup Kumar Talukder, Tofazzal Islam, A. N. M. Aminoor Rahman, M. Nazmul Hoque   +10 more
wiley   +1 more source

Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use

Antibiotics, 2021
The β-lactams have a central place in the antibacterial armamentarium, but the increasing resistance to these drugs, especially among Gram-negative bacteria, is becoming one of the major threats to public health worldwide.
Davide Carcione, Claudia Siracusa, Adela Sulejmani, Valerio Leoni, Jari Intra   +4 more
doaj   +1 more source

Identification and Genomic Analysis of the First Salmonella typhimurium Monophasic Variant 1,4,[5],12:i:‐ Isolate Harbouring a Chromosomally Integrated blaNDM‐5

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
This study reports the first clinical isolate of the monophasic variant of Salmonella typhimurium (serotype 1,4,[5],12:i:‐) ST34 harbouring a chromosomally integrated blaNDM‐5. The ~11 kb resistance region is flanked by two directly oriented IS26 elements, forming an IS26‐composite transposon.
Shihan Zeng, Weilong Guo, Chengfeng Lin, Lianghui Peng, Jingjie Song   +4 more
wiley   +1 more source

Environmental species from theTelluria group as the putative origin of bifunctionalβ-lactamases

Microbiology Spectrum
β-Lactamases comprise two structurally and evolutionarily well-defined groups: serine- (SBL) and metallo-β-lactamases (MBL). To date, clinically relevant β-lactamases are typically monofunctional DD-peptidases, containing a single active site cavity per ...
Pedro Penzotti, Gabriel Gutkind, Rachel A. Powers, Pablo Power   +3 more
doaj   +1 more source

Design of Primers for Detection and Typing of β-Lactamase Genes from Pathogenic Species of Burkholderia

Проблемы особо опасных инфекций, 2012
The set of oligonucleotide primers was designed to identify β-lactam-resitance determinats in isolates of pathogenic Burkholderia using PCR. Simultaneously identified was certain molecular class of detected β-lactamases.
A. V. Romanova, I. B. Zakharova, V. S. Zamaraev, D. V. Viktorov   +3 more
doaj   +1 more source

Phage Therapy as an Alternative Strategy Against Pseudomonas aeruginosa: A Narrative Review of Preclinical and Clinical Evidence

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Phage therapy shows promising efficacy against MDR, XDR, and PDR Pseudomonas aeruginosa infections across different models and administration routes. Evidence highlights reduced mortality, bacterial clearance, and synergy with antibiotics, while emphasizing the need for standardized protocols and advanced delivery systems to support clinical ...
Gustavo Aparecido da Cunha, Raine Piva Amaral, Ana Luisa Cauvila dos Santos, Bárbara Rafaela Ferreira Aio, Maria Fernanda Romboli Durante, Luiz Cosme Cotta Malaquias, Gabriel Magno de Freitas Almeida, Luiz Felipe Leomil Coelho   +7 more
wiley   +1 more source

Potential inhibitors designed against NDM-1 type metallo-β-lactamases: an attempt to enhance efficacies of antibiotics against multi-drug-resistant bacteria

Scientific Reports, 2017
NDM-1 and its variants are the most prevalent types of metallo-β-lactamases, hydrolyze almost all antibiotics of β-lactam group leading to multiple-drug resistance in bacteria.
Asad U. Khan, Abid Ali, Danishuddin, Gaurava Srivastava, Ashok Sharma   +4 more
doaj   +1 more source

Gut Microbiota Alterations Associated With Colonization by Multidrug‐Resistant Organisms in ICU Patients: First Systematic Review and Meta‐Analysis

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Microbiota profiling showed colonized critically ill patients had lower values of dominance/evenness (Simpson's index) and richness (Observed), reaching significantly lower values of information (mean difference in Shannon index = –1.18; 95% CI, –1.84 to –0.52; p < 0.001).
Andra‐Elena Goicea, Daniel‐Corneliu Leucuța, Constantin Bodolea   +2 more
wiley   +1 more source

Functional dynamics of water in New Delhi metallo‐β‐lactamase catalysis

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Water plays a critical role in the hydrolysis of antibiotics by New Delhi metallo‐β‐lactamases (NDMs). The reaction proceeds through a nucleophilic attack on the β‐lactam ring, followed by cleavage of the C–N bond and formation of an anionic nitrogen intermediate. This intermediate is then protonated by a water molecule diffusing from the bulk
Palanisamy Kandhan, Chuanye Xiong, Timothy Palzkill, Peng Tao   +3 more
wiley   +1 more source