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An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains [PDF]

Microbiology Spectrum, 2022
Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human ...
Valérian Lupo, Paola Sandra Mercuri, Jean-Marie Frère, Bernard Joris, Moreno Galleni, Denis Baurain, Frédéric Kerff   +6 more
doaj   +2 more sources

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding [PDF]

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +2 more sources

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

Antimicrobial Agents and Chemotherapy, 2020
QPX7728 is an ultrabroad-spectrum boronic acid beta-lactamase inhibitor, with potent inhibition of key serine and metallo-beta-lactamases being observed in biochemical assays.
Olga Lomovskaya, Ruslan Tsivkovski, Dongxu Sun   +2 more
exaly   +2 more sources

Extended-Spectrum Beta-Lactamases [PDF]

Canadian Journal of Infectious Diseases and Medical Microbiology, 2006
The definition of extended-spectrum beta-lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world.
Kevin R Forward
doaj   +2 more sources

Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases. [PDF]

PLoS Computational Biology, 2016
Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence ...
David Lee, Sayoni Das, Natalie L Dawson, Dragana Dobrijevic, John Ward, Christine Orengo   +5 more
doaj   +2 more sources

Peptidase Activity of Beta-Lactamases [PDF]

The Biochemical journal, 1999
peer reviewedAlthough beta-lactamases have generally been considered as being devoid of peptidase activity, a low but significant hydrolysis of various N-acylated dipeptides was observed with representatives of each class of beta-lactamases.
Page, Michael I., Rhazi, Noureddine, Frère, Jean Marie, Galleni, Moreno, Frère, Jean-Marie   +4 more
core   +3 more sources

Beta-lactamases in Enterobacteriaceae infections in children

Journal of Infection, 2016
Multi-drug resistance in Gram negative bacteria, particularly in Enterobacteriaceae, is a major clinical and public health challenge. The main mechanism of resistance in Enterobacteriaceae is linked to the production of beta-lactamase hydrolysing enzymes
Moxon, CA, Paulus, S, Moxon, Christopher Alan, Paulus, Stéphane   +3 more
core   +2 more sources

Prevalence of extended-spectrum beta-lactamases, AmpC beta-lactamase, and metallo-beta-lactamase producing Pseudomonas aeruginosa and Acinetobacter baumannii in an intensive care unit in a tertiary care hospital

Journal of the Scientific Society, 2013
Background: Resistance to broad-spectrum beta-lactams, mediated by extended-spectrum beta-lactamases (ESBL), AmpC beta-lactamase, and metallo-beta-lactamase (MBL) enzymes, is an increasing problem worldwide. Aim of the study: This study was undertaken to
Varun Goel, Sumati A Hogade, S G Karadesai   +2 more
doaj   +2 more sources

Controversies about Extended-Spectrum and AmpC Beta-Lactamases

Emerging Infectious Diseases, 2001
Many clinical laboratories have problems detecting extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated AmpC beta-lactamases. Confusion exists about the importance of these resistance mechanisms, optimal test methods, and appropriate reporting ...
Kenneth S. Thomson
doaj   +2 more sources

Occurrence and characteristics of extended spectrum beta-lactamases-producing Enterobacteriaceae from foods of animal origin

Brazilian Journal of Microbiology, 2016
Presence of extended spectrum beta-lactamases (ESBL) in bacteria is a growing health concern of global significance. The local, regional, national, and international epidemiological studies for extended spectrum beta-lactamases-producing ...
Tekiner, İsmail Hakkı, Özpınar, Haydar   +1 more
core   +2 more sources