Results 1 to 10 of about 57,530 (301)

An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains [PDF]

Microbiology Spectrum, 2022
Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human ...
Valérian Lupo, Paola Sandra Mercuri, Jean-Marie Frère, Bernard Joris, Moreno Galleni, Denis Baurain, Frédéric Kerff   +6 more
doaj   +2 more sources

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding [PDF]

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +2 more sources

Occurrence of Carbapenemases, Extended-Spectrum Beta-Lactamases and AmpCs among Beta-Lactamase-Producing Gram-Negative Bacteria from Clinical Sources in Accra, Ghana [PDF]

Antibiotics, 2023
Noah Obeng-Nkrumah, Nicholas T K D Dayie, Japheth Awuletey Opintan   +2 more
exaly   +2 more sources

Epidemiology of Plasmid Lineages Mediating the Spread of Extended-Spectrum Beta-Lactamases among Clinical Escherichia coli [PDF]

MSystems, 2022
Bejan Mahmud, Carol Muenks, Carey-Ann D Burnham   +2 more
exaly   +2 more sources

Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2020
Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu., Kozel Yu.Yu., Rozenko D.A., Martynov D.V., Korshunkova O.V.   +4 more
doaj   +1 more source

Phenotypic Characterization of Extended-Spectrum Beta-Lactamases and Metallo-Beta-Lactamase of Multi Drug Resistant Acinetobacter baumannii Causing Nosocomial Infections in Erbil City

Al-Mustansiriyah Journal of Science, 2020
Background: Resistance to broad‑spectrum beta‑lactams, mediated by extended‑spectrum beta‑lactamases, and metallo‑beta‑lactamase enzymes, is an increasing problem worldwide.
Sakar Bakr Smail, Kamal I. AL-OTRACHI
doaj   +1 more source

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) [PDF]

, 2016
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients.
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core   +7 more sources

Бета-лактамази ентеробактерій: загальна характеристика, механізми та регіональні особливості розповсюдження

Annals of Mechnikov's Institute, 2022
The problem of the formation and spread of resistance to β-lactam antibiotics in clinically significant types of microorganisms is extremely important, since β-lactams traditionally form the basis of the treatment of bacterial infections.
Olena Peretyatko, Yuliia Yagniuk, Nadiya Sklyar, Galina Bolshakova, Tetyana Holodna   +4 more
doaj   +1 more source

In Silico Assigned Resistance Genes Confer Bifidobacterium with Partial Resistance to Aminoglycosides but Not to Β-Lactams [PDF]

, 2013
peer-reviewedBifidobacteria have received significant attention due to their contribution to human gut health and the use of specific strains as probiotics.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, O'Connell-Motherway, Mary, Ross, R Paul, STANTON, CATHERINE, van Sinderen, Douwe   +6 more
core   +16 more sources

Dissemination of IncF plasmids carrying beta-lactamase genes in Gram-negative bacteria from Nigerian hospitals

Journal of Infection in Developing Countries, 2013
Introduction: Production of beta-lactamases is the predominant cause of resistance to beta-lactam antibiotics in Gram-negative bacteria. We investigated the diversity of plasmid-borne beta-lactamase genes and replicon type of the plasmids carrying the ...
David Olusoga Ogbolu, Oluwole Adebayo Daini, Afolabi Ogunledun, Oyebode Armstrong Terry Alli, Mark Alexander Webber   +4 more
doaj   +1 more source