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, 2019 Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile.
Blanco, Ana +5 more
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Beta-Lactams [electronic resource] : Novel Synthetic Pathways and Applications /
, 2017 This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis ...
SpringerLink (Online service) +1 more
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Antibiotics, 2021 Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on the percentage of dosing interval that the concentration remains ...
Mohammad H Al-Shaer +2 more
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Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing [PDF]
, 2022 The increasing threat of drug resistance and a stagnated pipeline of novel therapeutics endanger the eradication of tuberculosis. Beta-lactams constitute promising additions to the current therapeutic arsenal and two carbapenems are included in group C ...
Olivença, Francisco +8 more
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, 2023 The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial ...
Jed F. Fisher, Shahriar Mobashery
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Zeitschrift für Naturforschung B, 1969 Since the discovery 11 of the activating effect of the N- (p-Nitro-phenyl)-group on the methine hydrogen of halogenacetamino esters, it has been found that the p-Acetyl-phenyl and m-Nitro-phenyl groups exert a similar effect. It has been shown that the delocalisation of the N-non-bonded electrons across the orbitals of the N-Aryl substituent is the ...
B G, Chatterjee, R F, Abdulla
openaire +2 more sources
Synthesis of type II beta-turn surrogate dipeptides based on syn-alfa-amino-alfa, beta-dialkyl-beta-lactams [PDF]
, 2004 The achiral bis(trimethylsilyl)methyl group acts as an efficient stereochemical determinant of the α-alkylation reaction in β-branched α-phenyloxazolidinyl- or α-diphenyloxazolidinyl-β-lactams and provides the first stereocontrolled access to syn-α-amino-
Palomo, Claudio +11 more
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, 2014 This work is supported by a Royal Society for a University Research Fellowship and the EPSRC and GSK (Case Award) as well as by the European Research Council under the European Unionʼs Seventh Framework Programme (FP7/2007-2013) (ERC Grant Agreement No ...
Prevet, Hugues +5 more
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New Polyphenolic-Beta-Lactams with Antioxidant Activity.
, 2008 Novel 4-alkylidene-beta-lactams with a polyphenolic side chain were synthesized and evaluated as radical scavengers. We have undertaken a detailed study of the antioxidant activity in vitro with chemical and biological testing of the new beta-lactams and
GIACOMINI, DARIA +6 more
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BETA-LACTAMS FROM CHIRALLY-ENRICHED (ALLENYLMETHYL)SILANES
, 1993 Functionalised (allenylmethyl)silanes react with chlorosulphonyl isocyanate in a highly regioselective manner to provide beta-lactams with the side-chain functionality of the asparenomycins.
Ivan Tommasini +9 more
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