Antibiotics, 2021 Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on the percentage of dosing interval that the concentration remains ...
Mohammad Al-Shaer, Charles A Peloquin
exaly +3 more sources
Recent Evolution of Susceptibility to Beta-Lactams in Neisseria meningitidis [PDF]
Antibiotics, 2023 Beta-lactams are the main antibiotics for the treatment of invasive meningococcal disease. However, reduced susceptibility to penicillin G is increasingly reported in Neisseria meningitidis and reduced susceptibility to third-generation cephalosporines ...
Ala-Eddine Deghmane +2 more
doaj +2 more sources
Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review [PDF]
Frontiers in AntibioticsOrthotopic liver transplant (OLT) represents the standard of care for managing patients affected by end-stage and life-threatening liver diseases.
Milo Gatti +3 more
doaj +2 more sources
Extended Infusion of Beta-Lactams and Glycopeptides: A New Era in Pediatric Care? A Systematic Review and Meta-Analysis [PDF]
AntibioticsOptimizing antibiotic therapy is imperative with rising bacterial resistance and high infection mortality. Extended infusion defined as a continuous infusion (COI) or prolonged infusion (PI) of beta-lactams and glycopeptides might improve efficacy and ...
Andrea Rahel Burch +3 more
doaj +2 more sources
PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance [PDF]
Microorganisms, 2018 β-lactam antibiotics are excellent drugs for treatment of staphylococcal infections, due to their superior efficacy and safety compared to other drugs.
Thaina M. da Costa +3 more
doaj +4 more sources
Rise of the beta-lactams: a retrospective, comparative cohort of oral beta-lactam antibiotics as step-down therapy for hospitalized adults with acute pyelonephritis [PDF]
Antimicrobial Stewardship & Healthcare EpidemiologyObjective: The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.
Athena L.V. Hobbs +5 more
doaj +2 more sources
Liver Metabolomics and Inflammatory Profiles in Mouse Model of Fentanyl Overdose Treated with Beta-Lactams [PDF]
Metabolites, 2023 Fawaz Alasmari +2 more
exaly +2 more sources
The current view on betalactam resistance in Staphylococcus aureus [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2021 The review presents the current view on the different resistance mechanisms of Staphylococcus aureus to beta-lactams, which are ones of the main antibiotics of choice for the treatment of staphylococcal infections. Currently, there are several mechanisms
Gostev V.V. +2 more
doaj +1 more source
Hypotheses for synthesis of novel chiral beta-amino-beta-lactams through amidines
Results in Chemistry, 2021 Synthesis of new beta-lactams is an attractive field because some of these types of molecules are biologically active. The design and preparation of C4-nitrogen-substituted beta-lactams are not known.
Bimal Krishna Banik, Alberto Boretti
doaj +1 more source
World Allergy Organization Journal, 2023 Background: Although beta-lactams are 1 of the major causative agents of severe cutaneous adverse reactions (SCAR), their epidemiology and clinical aspects have been poorly studied.
Min-Hye Kim, MD, PhD +16 more
doaj +1 more source