Beta-Lactams Dosing in Critically Ill Patients with Gram-Negative Bacterial Infections: A PK/PD Approach [PDF]
Antibiotics, 2021 Beta-lactam antibiotics are often the backbone of treatment for Gram-negative infections in the critically ill. Beta-lactams exhibit time-dependent killing, and their efficacy depends on the percentage of dosing interval that the concentration remains ...
Kelly L. Maguigan +2 more
doaj +4 more sources
Recent Evolution of Susceptibility to Beta-Lactams in Neisseria meningitidis [PDF]
Antibiotics, 2023 Beta-lactams are the main antibiotics for the treatment of invasive meningococcal disease. However, reduced susceptibility to penicillin G is increasingly reported in Neisseria meningitidis and reduced susceptibility to third-generation cephalosporines ...
Ala-Eddine Deghmane +2 more
doaj +2 more sources
, 2019 Beta-lactam antibiotics are the most popular antibacterial agents used for treating bacterial infections, due to their great activity, broad spectrum, and safety profile. All of them share the beta-lactam ring and because of the particular chemical structure, they are classified into five groups: Penicillins (natural and semisynthetic), cephalosporins (
Balsalobre, Luz +2 more
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Pharmacokinetic/pharmacodynamic issues for optimizing treatment with beta-lactams of Gram-negative infections in critically ill orthotopic liver transplant recipients: a comprehensive review [PDF]
Frontiers in AntibioticsOrthotopic liver transplant (OLT) represents the standard of care for managing patients affected by end-stage and life-threatening liver diseases.
Milo Gatti +3 more
doaj +2 more sources
Extended Infusion of Beta-Lactams and Glycopeptides: A New Era in Pediatric Care? A Systematic Review and Meta-Analysis [PDF]
AntibioticsOptimizing antibiotic therapy is imperative with rising bacterial resistance and high infection mortality. Extended infusion defined as a continuous infusion (COI) or prolonged infusion (PI) of beta-lactams and glycopeptides might improve efficacy and ...
Andrea Rahel Burch +3 more
doaj +2 more sources
Rise of the beta-lactams: a retrospective, comparative cohort of oral beta-lactam antibiotics as step-down therapy for hospitalized adults with acute pyelonephritis [PDF]
Antimicrobial Stewardship & Healthcare EpidemiologyObjective: The aim of this study was to determine if oral beta-lactam therapy is non-inferior to alternative therapy at discharge following inpatient treatment with an IV cephalosporin for acute pyelonephritis.
Athena L.V. Hobbs +5 more
doaj +2 more sources
Liver Metabolomics and Inflammatory Profiles in Mouse Model of Fentanyl Overdose Treated with Beta-Lactams [PDF]
Metabolites, 2023 Nemat Ali +2 more
exaly +2 more sources
The current view on betalactam resistance in Staphylococcus aureus [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2021 The review presents the current view on the different resistance mechanisms of Staphylococcus aureus to beta-lactams, which are ones of the main antibiotics of choice for the treatment of staphylococcal infections. Currently, there are several mechanisms
Gostev V.V. +2 more
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Hypotheses for synthesis of novel chiral beta-amino-beta-lactams through amidines
Results in Chemistry, 2021 Synthesis of new beta-lactams is an attractive field because some of these types of molecules are biologically active. The design and preparation of C4-nitrogen-substituted beta-lactams are not known.
Bimal Krishna Banik, Alberto Boretti
doaj +1 more source
β-Lactams from the Ocean [PDF]
, 2023 The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial ...
Jed F. Fisher, Shahriar Mobashery
core +1 more source