Results 21 to 30 of about 60,277 (349)
An update on the synthesis and reactivity of spiro-fused β-lactams [PDF]
, 2018 Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic ...
D'hooghe, Matthias, Dao Thi, Hang
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Pharmaceuticals, 2021 Antibiotic resistance is a major health problem worldwide, causing more deaths than diabetes and cancer. The dissemination of vertical and horizontal antibiotic resistance genes has been conducted for a selection of pan-resistant bacteria.
Rosalino Vázquez-López +8 more
doaj +1 more source
Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates. [PDF]
PLoS ONE, 2009 BACKGROUND: Beta-lactamase production and porin decrease are the well-recognized mechanisms of acquired beta-lactam resistance in Klebsiella pneumoniae isolates. However, such mechanisms proved to be absent in K.
Jean-Marie Pages +6 more
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Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones [PDF]
, 2018 Because of the beneficial effect of a trifluoromethyl group on the biological properties of bioactive compounds on the one hand and the versatile synthetic potential of beta-lactams on the other hand, 4-CF3-beta-lactams comprises interesting entities for
D'hooghe, Matthias +2 more
core +1 more source
Antibiotics, 2022 Aim: The aim of the study was to evaluate the in vitro activity of N-acetylcysteine (NAC), alone or in combination with beta-lactams, against carbapenem-resistant Klebsiella pneumoniae (CR-Kp) and Acinetobacter baumannii (CR-Ab).
Massimiliano De Angelis +9 more
doaj +1 more source
Rhodium-catalysed hydroformylation of N-(2-propenyl)-β-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides [PDF]
, 2010 Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)-beta-lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the ...
D'hooghe, Matthias +4 more
core +2 more sources
Allergology International, 2011 Background: The leukocyte migration test (LMT) is effective in identifying the causative drug in drug allergies. Both leukocyte migration activating activity (LMAA) and leukocyte migration inhibitory activity (LMIA) are involved in the development of ...
Manabu Abe +4 more
doaj +1 more source
Oral beta-lactam step down in bacteremic E. coli urinary tract infections
BMC Infectious Diseases, 2020 Background Literature is scarce regarding oral step down to beta-lactams in bacteremic urinary tract infections. Oral fluoroquinolones are an accepted and common step down for bacteremic urinary tract infections; however, their use is associated with ...
Stephan Saad +3 more
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Frontiers in Cellular and Infection Microbiology, 2023 The lack of effective therapeutics against emerging multi-drug resistant strains of Mycobacterium tuberculosis (Mtb) prompts the identification of novel anti-tuberculosis targets.
Cátia Silveiro +10 more
doaj +1 more source
SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children [PDF]
, 2018 Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs).
Arasi, Stefania +19 more
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