Design, synthesis, and evaluation the anti-β-lactamase activity of new sulphathiazole-derived monobactam compounds [PDF]
المجلة العراقية للصيدلة, 2020 Objectives: β-Lactams are the most successful antibiotics for the management of infectious diseases. Unfortunately, the bacterial production of β-lactamase that hydrolyzes the β-lactam ring can inactivate these drugs.
Ahmed Mahmood +2 more
doaj +1 more source
BETA-LACTAMS FROM CHIRALLY-ENRICHED (ALLENYLMETHYL)SILANES [PDF]
, 1993 Functionalised (allenylmethyl)silanes react with chlorosulphonyl isocyanate in a highly regioselective manner to provide beta-lactams with the side-chain functionality of the asparenomycins.
Ivan Tommasini +9 more
core +1 more source
Beta-lactams against methicillin-resistant Staphylococcus aureus [PDF]
, 2005 Methicillin-resistant Staphylococcus aureus (MRSA) have developed resistance to virtually all non-experimental antibiotics. They are intrinsically resistant to beta-lactams by virtue of newly acquired low-affinity penicillin-binding protein 2A (PBP2A ...
Guignard, Bertrand +5 more
core +1 more source
Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia:comparison of beta-lactams [PDF]
, 2010 Several beta-lactams are recommended as single agents for the treatment of febrile ...
Yahav, Dafna +9 more
core +1 more source
Antibiotics, 2021 Selective pressure of beta-lactams is thought to be responsible for mutation selection in methicillin-susceptible Staphylococcus aureus (MSSA). We used next-generation sequencing to compare the genomes of beta-lactamase-positive (SA0707) and -negative ...
Vladimir Gostev +6 more
doaj +1 more source
Synthesis of type II beta-turn surrogate dipeptides based on syn-alfa-amino-alfa, beta-dialkyl-beta-lactams [PDF]
, 2004 The achiral bis(trimethylsilyl)methyl group acts as an efficient stereochemical determinant of the α-alkylation reaction in β-branched α-phenyloxazolidinyl- or α-diphenyloxazolidinyl-β-lactams and provides the first stereocontrolled access to syn-α-amino-
Palomo, Claudio +11 more
core +1 more source
Zagazig Journal of Pharmaceutical Sciences, 2016 This study aimed for the molecular detection of TEM and SHV genes in Extended-Spectrum beta-lactamases (ESBLs) clinical isolates of Enterobacteriace (Eshericichia coli, Klebsiella pneumoniae and Proteus spp.).
Ashraf Kadry +2 more
doaj +1 more source
Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors
Frontiers in Microbiology, 2022 Beta-lactams have been excluded from tuberculosis therapy due to the intrinsic resistance of Mycobacterium tuberculosis (Mtb) to this antibiotic class, usually attributed to a potent beta-lactamase, BlaC, and to an unusually complex cell wall.
Francisco Olivença +8 more
doaj +1 more source
Facile synthesis of novel benzothiazolylpyrazolyl anchored 3-thio/seleno/chloro-β-lactams: Synthetic intermediates for novel 3-sulfenyl/sulfonyl, C-3 functionalized monocyclic and spirocyclic β-lactams [PDF]
, 2018 Efficient synthesis of a new series of 3-phenyl/benzylthio-4-benzothiazolylpyrazolyl-β-lactams is described. Treatment of 2-phenylthio/benzylthioacetic acid with benzothiazolylpyrazolyl substituted Schiff’s bases furnished trans-β-lactams exclusively ...
Jitender Bhalla (4284292) +2 more
core +1 more source
Evaluation of Risk Factors for Carbapenem-Resistant Klebsiella Pneumoniae Bacteremia
Southern Clinics of Istanbul Eurasia, 2020 INTRODUCTION[|]In recent years, carbapenem-resistant Klebsiella pneumoniae infections have become an important health problem in our country and all over the world.
Pınar Kıran +2 more
doaj +1 more source