Results 51 to 60 of about 612,998 (297)

Beta-Lactams from Unsaturated Organosilanes [PDF]

, 1992
The synthesis of beta-lactams from allyl- and (allenylmethyl)silanes, such as (167) and (256), was achieved by a combination of the olefin/CSI approach to beta-lactams, developed by Graf, and the Na2SO3 reduction system used by Durst and O'Sullivan.
Tommasini, Ivan
core  

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Beta‐lactam versus beta‐ lactam/macrolide therapy in pediatric outpatient pneumonia [PDF]

Pediatric Pulmonology, 2015
SummaryObjectiveThe objective was to evaluate the comparative effectiveness of beta‐lactam monotherapy and beta‐ lactam/macrolide combination therapy in the outpatient management of children with community‐acquired pneumonia (CAP).MethodsThis retrospective cohort study included children, ages 1–18 years, with CAP diagnosed between January 1, 2008 and ...
Lilliam, Ambroggio, Matthew, Test, Joshua P, Metlay, Thomas R, Graf, Mary Ann, Blosky, Maurizio, Macaluso, Samir S, Shah   +6 more
openaire   +2 more sources

An electrochemical alternative strategy to the synthesis of beta-lactams via N-C4 bond formation [PDF]

, 2005
A simple electrochemical synthesis of beta-lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides.
Palombi L, Feroci M, Inesi A., Orsini M, ROSSI, LEUCIO   +4 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Strain‐Release Pentafluorosulfanylation of Carbonyl‐Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF5‐Containing Oxa[2.1.1]bicyclohexanes

Angewandte Chemie, EarlyView.
A regio‐ and diastereoselective method for strain‐release pentafluorosulfanylation of carbonyl‐containing 1,3‐disubstituted [1.1.0]bicyclobutanes (BCBs) was developed that led to several fortuitous discoveries. For instance, the resultant SF5‐cyclobutanes (SF5‐CBs) exhibit close SF5⋯C═X contacts (X = C, N, O) and provide synthetic access to a new class
Alexander M. Stephens, Jake Anthony Olvera, Yannick Kraemer, Tyson Vu, Wang‐Yeuk Kong, Sudiksha Chaturvedi, Jeffrey M. Wang, Lauren M. Holder, Dean J. Tantillo, Cody Ross Pitts   +9 more
wiley   +2 more sources

Investigations On The Resistance Of Porcine Commensal E. Coli Isolates To Beta Lactams

Acta Veterinaria, 2015
The aim of this study was to describe the prevalence of antibiotic resistance to beta-lactams and to evaluate two resistance genes blaTEM and blaOXA-1 in Escherichia coli isolates from faeces on six swine farms in the Republic of Bulgaria. A total of 186
Urumova Valentina
doaj   +1 more source

Evaluation and characterization of 125 patients with a history of reaction to beta-lactams

Revista Alergia México, 2016
Background: Reactions to beta-lactams are frequent and it is difficult to establish the relationship between the drug and symptoms. Objective: To describe the clinical characteristics and explore the immunological mechanisms of patients with suspected ...
Kaddy Juliana Beltrán-Sierra, Jorge Sánchez, Ricardo Cardona   +2 more
doaj   +1 more source

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

Angewandte Chemie, EarlyView.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources