Results 61 to 70 of about 612,998 (297)

Right-sided native-valve infective endocarditis caused by : A case report

SAGE Open Medical Case Reports, 2022
Streptococcus acidominimus is rarely pathogenic in humans. In the literature, there are only few cases related to S. acidominimus , including pneumonia, meningitis, brain abscess, pericarditis, sepsis, and endocarditis.
Liyana Arachchige Dona Thulini Madubashini, Jayawardane Pathiranage Roneesha Lakmali, Chandrasiri N Shirani, Anne Thushara Matthias   +3 more
doaj   +1 more source

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams [PDF]

, 2018
Glycosylation significantly alters the biological and physicochemical properties of small molecules. beta-Lactam alcohols comprise eligible substrates for such a transformation based on their distinct relevance in the chemical and medicinal community. In
Piens, Nicola, Dewitte, Griet, Decuyper, Lena, Shari Dhaene (5953292), Matthias D’hooghe, Kevin Vandoorne, Lena Decuyper, Maarten Debruyne, Desmet, Tom, Kevin Vandoorne (5953298), Debruyne, Maarten, Lena Decuyper (5953286), Maarten Debruyne (5953295), Shari Dhaene, Tom Desmet (1474720), Nicola Piens, Tom Desmet, Griet Dewitte (1474732), Franceus, Jorick, Jorick Franceus, D'hooghe, Matthias, Jorick Franceus (5953289), Matthias D’hooghe (1789012), Nicola Piens (5953301), Dhaene, Shari, Vandoorne, Kevin, Griet Dewitte   +26 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Photochemical Ring Opening of Cyclopropyl Silyl Ethers Enables β–β Coupling, Radical‐Polar Crossover and Annulation

Angewandte Chemie, EarlyView.
A photochemical platform enables β–β coupling of cyclopropyl silyl ethers with electron‐deficient alkenes. The resulting adducts serve as entry points into annulative and radical–polar crossover pathways, providing rapid access to fused, bridged, and spirocyclic architectures, including late‐stage scaffold diversification to diterpene‐like carbocyclic ...
Jacop Rydén, Eilidh Young, Wilma Olsson, Eskil Flodén, Mattias Tan, Sebastian Clementson   +5 more
wiley   +2 more sources

Network meta-analysis of success rate and safety in antibiotic treatments of bronchitis

International Journal of COPD, 2017
Jinghua Wang,1 Haiyang Xu,2 Pan Liu,3 Mingxian Li4 1Pediatric of Rheumatology, Immunology and Allergy, The First Hospital of Jilin University, Changchun, 2Department of Anesthesiology, The First Hospital of Jilin University, Changchun, 3Department of ...
Wang J, Xu H, Liu P, Li M
doaj  

Stereoselective synthesis of 3,4-diaryl-beta-lactams [PDF]

, 2009
Novel 3,4-diaryl beta-lactams were prepared with high stereoselectivity in an efficient manner by a palladium- catalyzed [2+2] carbonylative cycloaddition of benzyl halides with heteroarylidene amines.
V. STRUSI, E. PINDINELLI, TROISI, Luigino, P. TRINCHERA   +3 more
core  

High‐Density E. Coli Cultivation Arrays for Combinatorial Drug Testing With Subsequent Lipid Profiling by MALDI‐MS

Advanced Science, EarlyView.
High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld, C. L. Dietsche, F‐L. Born, I. Onipko, L. Blaase, P. S. Dittrich   +5 more
wiley   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Trifluoromethylated Pyrimidines Starting From Beta-trifluoroacetyl-lactams, Beta-trifluoroacetyl-lactone and Beta-trifluoroacetyl-cyclanone [PDF]

, 1994
A synthesis of trifluoromethylated pyrimidines from beta-trifluoroacetyl-lactams and -benzolactams is accomplished by reaction with benzamidine as bis-nucleophile. This condensation is also extended to cyclic trifluoromethylated 1,3-diketones and 3-aroyl-
Janousek, Z., Bouillon, JP., Wynants, C., Bouillon, V., Viehe, HG.   +4 more
core   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source