Results 61 to 70 of about 611,430 (255)
SYNTHESIS OF HETEROCYCLES THROUGH BETA LACTAMS RING RUPTURE
, 2018 Many Beta lactams are widely used as medicines. The 4-membered ring present in the beta lactams is under strain and therefore, it can undergo cleavage reactions to diverse compounds.
Banik, Bimal K.
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Drug Testing and Analysis, EarlyView.A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler +3 more
wiley +1 more source
Antibacterial Activity of Heteropolytungstates Against Proteus mirabilis
European Journal of Inorganic Chemistry, EarlyView.We investigated the in vitro antibacterial activity of several heteropolytungstates against P. mirabilis, a drug‐resistant pathogen. All tested polyanions inhibited bacterial growth, with the Preyssler–Pope–Jeannin polyanion P5W30 exhibiting the highest activity (MIC = 0.78 mg/mL).
Nour El Ghouch +5 more
wiley +1 more source
A facile synthesis of new beta-lactams
, 1996 Several new beta-lactams have been synthesized in good yields, via the cyclization of 3-chloro-N-arylpropionamides in a mixture of N,N-dimethylformamide and anhydrous sodium carbonate under a nitrogen ...
H. ElKashef +6 more
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The Synthesis of Functionalised beta-Lactams [PDF]
, 1988 N-t-Butyldimethylsilyl imines were prepared readily by oxidation of the corresponding primary amines. The application of N-t-butyl-dimethylsilyl imines to the synthesis of monocyclic beta-lactams was examined via the ester-imine condensation reaction ...
Nugent, Mark James
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Ynolate Chemistry. Reaction of a Silylynolate with Aziridines Leading to γ-Lactams
, 2016 A silylynolate, generated via the carbonylation of lithium silyldiazomethane, was reacted with N-tosyl aziridines to produce various five-membered lactams in good yields.
Naoto Chatani (1364754) +3 more
core +1 more source
European Journal of Organic Chemistry, EarlyView.1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source
European Journal of Organic Chemistry, EarlyView.Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová +6 more
wiley +1 more source
, 2002 Partendo dalla recente pubblicazione di un volume curato da D. Harvey e J. Wilkins (The rivals of Aristophanes. Studies in Athenian Old Comedy, London 2000), Simone Beta discute sull'importanza dello studio dei frammenti comici per una conoscenza ...
BETA, SIMONE, Simone Beta
core +1 more source
European Journal of Organic Chemistry, EarlyView.Effective synthesis of 3‐substituted isoindolinones is possible through novel cascade reactions of alkyl arylacetates with 2‐cyanobenzaldehydes under mild, basic conditions. Herein we report the use of alkyl arylacetates as pro‐nucleophiles in cascade reactions with 2‐cyanobenzaldehydes leading to the formation of novel 3‐substituted isoindolinones, a ...
Antonia Di Mola +4 more
wiley +1 more source