Results 71 to 80 of about 60,277 (349)

Self‐reported drug allergy in a general adult Portuguese population [PDF]

, 2004
Clin Exp Allergy. 2004 Oct;34(10):1597-601. Self-reported drug allergy in a general adult Portuguese population. Gomes E, Cardoso MF, Praça F, Gomes L, Mariño E, Demoly P.
Adkinson N., Asero R., Barranco P, Bigby M., Bowrey DJ, Haddi E, Kerr JR., Miller R., Pilzer JD, Preston SL, Preston SL, Quaratino D, Quaratino D, Romano A, Tripp DM, Vervloet D, Weiss M   +16 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Significance of Self‐Expandable Metallic Stent for Postoperative Intra‐Abdominal Infection After Pancreatoduodenectomy in Patients With a Hard Pancreas

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Self‐expandable metal stents (SEMS) are often used for preoperative biliary drainage in pancreatoduodenectomy (PD); however, their impact on postoperative intra‐abdominal infection (POAI) remains unclear. This study aimed to evaluate the clinical significance of SEMS in relation to POAI.
Kosuke Mori, Haruyoshi Tanaka, Nana Kimura, Mina Fukasawa, Ayaka Itoh, Yoshihiro Shirai, Kazuto Shibuya, Kentaro Nagaoka, Yoshihiro Yamamoto, Tsutomu Fujii   +9 more
wiley   +1 more source

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature Communications, 2016
Bacterial beta-lactamases are responsible for resistance to beta-lactams, the most important family of antibiotics. Here, the authors reveal cyclic boronate inhibitors that are active against both serine- and metallo-beta-lactamases and represent a ...
Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, Christopher J. Schofield   +9 more
doaj   +1 more source

Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting [PDF]

, 2019
Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians ...
Avery, Lisa M., Bookstaver, P. Brandon, Justo, Julie Ann, Kufel, Wesley D.   +3 more
core   +3 more sources

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Impact of Extending Beta-Lactam Infusions on IV Access Requirements

Critical Care Explorations
This study aimed to determine if extended infusion (EI; over > 3 hr) beta-lactam therapy increased IV access requirements compared with traditional dosing (TD; over 30 min).
Kirstin J. Kooda, PharmD, Julia Nelson, BS, Sara E. Ausman, PharmD, Christina G. Rivera, PharmD, Omar M. Abu Saleh, MBBS, Andrew D. Rule, MD, Ryan W. Stevens, PharmD, Micaela N. Warfield, PharmD, Yanjun Zhao, PharmD, Erin F. Barreto, PharmD, PhD, on behalf of the Beta Lactam Optimization and Outcomes Management (BLOOM) Study Group, Laura M. Dinnes, PharmD, Ognjen Gajic, MD, Laurie A. Meade, RN, Rebecca J. Wessel, DPT, MBA.   +14 more
doaj   +1 more source

Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation

Frontiers in Microbiology, 2018
Acinetobacter nosocomialis is a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. Increasingly, reports are emerging of the pathogenic profile and multidrug resistance (MDR) phenotype of this species.
Daniel B. Knight, Susan D. Rudin, Susan D. Rudin, Susan D. Rudin, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Philip N. Rather, Philip N. Rather, Philip N. Rather   +9 more
doaj   +1 more source

Fluoroquinolone Versus Nonfluoroquinolone Treatment of Bloodstream Infections Caused by Chromosomally Mediated AmpC-Producing Enterobacteriaceae

Antibiotics, 2020
Objectives: Chromosomally mediated AmpC-producing Enterobacteriaceae (CAE) display high susceptibility to fluoroquinolones; minimal clinical data exist supporting comparative clinical outcomes.
Sarah Grace Gunter, Katie E. Barber, Jamie L. Wagner, Kayla R. Stover   +3 more
doaj   +1 more source

Resistance decay in individuals after antibiotic exposure in primary care: A systematic review and meta-analysis [PDF]

, 2012
Background Antibiotic resistance is an urgent global problem, but reversibility is poorly understood. We examined the development and decay of bacterial resistance in community patients after antibiotic use.
Bakhit, Mina, Hoffmann, Tammy, Scott, Anna Mae, Beller, Elaine, Rathbone, John, Del Mar, Chris   +5 more
core   +1 more source