Results 71 to 80 of about 612,998 (297)

Prevalence of antibiotic resistance genes in resistome of adult residents of Arkhangelsk with regard to the severity of COVID-19

Журнал инфектологии, 2023
Objective: to estimate the prevalence of antibiotic resistance genes in the resistome of adult residents of Arkhangelsk with regard to the severity of the novel coronavirus infection (COVID-19).Materials and methods. A cross-sectional study was conducted
E. A. Krieger, A. V. Pavlenko, Yu. P. Esin, A. L. Arkhipova, S. N. Kovalchuk, L. L. Shagrov, N. I. Belova, N. P. Tsyvareva, A. V. Kudryavtsev, E. N. Ilina   +9 more
doaj   +1 more source

Repurposing β-Lactams for the Treatment of Mycobacterium kansasii Infections: An In Vitro Study [PDF]

, 2023
Mycobacterium kansasii (Mkn) causes tuberculosis-like lung infection in both immunocompetent and immunocompromised patients. Current standard therapy against Mkn infection is lengthy and difficult to adhere to.
José A. Aínsa, Muñoz-Muñoz, Lara, Ramón-García, Santiago, Santiago Ramón-García, Lara Muñoz-Muñoz, Aínsa, José A.   +5 more
core   +1 more source

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Beta-lactams and Fluoroquinolones Dose Optimization in Critically Ill Patients:To TDM or not to TDM [PDF]

, 2022
Beta-lactams and Fluoroquinolones DoseOptimization in Critically Ill ...
Abdulla, Alan; id_orcid
core   +5 more sources

Impact of Extending Beta-Lactam Infusions on IV Access Requirements

Critical Care Explorations
This study aimed to determine if extended infusion (EI; over > 3 hr) beta-lactam therapy increased IV access requirements compared with traditional dosing (TD; over 30 min).
Kirstin J. Kooda, PharmD, Julia Nelson, BS, Sara E. Ausman, PharmD, Christina G. Rivera, PharmD, Omar M. Abu Saleh, MBBS, Andrew D. Rule, MD, Ryan W. Stevens, PharmD, Micaela N. Warfield, PharmD, Yanjun Zhao, PharmD, Erin F. Barreto, PharmD, PhD, on behalf of the Beta Lactam Optimization and Outcomes Management (BLOOM) Study Group, Laura M. Dinnes, PharmD, Ognjen Gajic, MD, Laurie A. Meade, RN, Rebecca J. Wessel, DPT, MBA.   +14 more
doaj   +1 more source

How beta-lactam antibiotics enter bacteria: a dialogue with the porins. [PDF]

PLoS ONE, 2009
BACKGROUND: Multi-drug resistant (MDR) infections have become a major concern in hospitals worldwide. This study investigates membrane translocation, which is the first step required for drug action on internal bacterial targets.
Chloë E James, Kozhinjampara R Mahendran, Alexander Molitor, Jean-Michel Bolla, Andrey N Bessonov, Mathias Winterhalter, Jean-Marie Pagès   +6 more
doaj   +1 more source

Intramolecular nitrilimine cycloadditions onto beta-lactams bearing an alkenyl dipolarophile : synthesis of novel tricyclic beta-lactams [PDF]

, 2010
A five-step synthesis of novel tricyclic beta-lactams has been exploited by stereoselective intramolecular cycloadditions of appropriate nitrilimines 6 and 12 These labile intermediates were generated in situ from the corresponding hydrazonoyl chlorides ...
Tullio Pilati, T. Pilati, Giorgio Molteni, G. Molteni, Paola Del Buttero, P. Del Buttero   +5 more
core   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with alpha,beta-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-gamma-lactones/lactams [PDF]

, 2015
Enantioselective Michael/c-ydization cascade reactions of 3-hydroxyoxindoles/3-aminooxindoles with alpha,beta-unsaturated acyl phosphonates by using a cinchonine derived squaramide as the catalyst were developed.
Zhang, Ming-Liang, Yuan, Wei-Cheng, Zhang, Xiao-Mei, Xu, Xiao-Ying, Chen, Lin, Wu, Zhi-Jun, Xu, XY (reprint author), Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China., Yue, Deng-Feng   +7 more
core   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source