Results 31 to 40 of about 1,753,858 (323)

Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment.

Saudi Journal of Biological Sciences, 2015
Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms.
Sibhghatulla Shaikh, Jamale Fatima, S. Shakil, S. M. Rizvi, M. Kamal   +4 more
semanticscholar   +1 more source

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Nature Communications, 2016
Bacterial beta-lactamases are responsible for resistance to beta-lactams, the most important family of antibiotics. Here, the authors reveal cyclic boronate inhibitors that are active against both serine- and metallo-beta-lactamases and represent a ...
Jürgen Brem, Ricky Cain, Samuel Cahill, Michael A. McDonough, Ian J. Clifton, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, James Spencer, Colin W. G. Fishwick, Christopher J. Schofield   +9 more
doaj   +1 more source

Prevalence of multiresistant gram-negative organisms in a tertiary hospital in Mwanza, Tanzania. [PDF]

, 2009
\ud Antimicrobial resistance is fast becoming a global concern with rapid increases in multidrug-resistant Gram negative organisms. The prevalence of extended spectrum beta-lactamase (ESBL)-producing clinical isolates increases the burden on implementing
Kamugisha, Erasmus, Chakraborty Trinad, Mirambo Mariam, Mshana, S.E., Mirambo, M., Stephen E Mshana, Mariam Mirambo, Kamugisha Erasmus, Erasmus Kamugisha, Mshana Stephen E, Lyamuya Eligius F, Mirambo, Mariam, Lyamuya, Eligius F, Eligius F Lyamuya, Chakraborty, T., Chakraborty, Trinad, Lyamuya, E.F., Mshana, Stephen E, Kamugisha, E., Trinad Chakraborty   +19 more
core   +1 more source

Molecular epidemiology and resistance patterns of blaOXA-48 Klebsiella pneumoniae and Escherichia coli: A nationwide multicenter study in Taiwan

Journal of Microbiology, Immunology and Infection, 2021
Background: We describe the molecular epidemiology and resistance patterns of blaOXA-48 Klebsiella pneumoniae and Escherichia coli in Taiwan. Methods: In this multicenter surveillance study from January 2012 to August 2015, the identified blaOXA-48 ...
Ching-Hsun Wang, Ling Ma, Li-Yueh Huang, Kuo-Ming Yeh, Jung-Chung Lin, L. Kristopher Siu, Feng-Yee Chang   +6 more
doaj   +1 more source

An Overview of Extended Spectrum Beta Lactamases and Metallo Beta Lactamases

Advances in Microbiology, 2021
Antibiotic resistant β-lactamases are diverse and complex enzymes produced by most of the Gram-negative bacteria that are mediated by number of plasmids. The impact of these enzymes has posed a major threat to the health sectors and has challenged the available treatment options for both community and hospital acquired infections.
Kavita Nagshetty, B. M. Shilpa, Shripad A. Patil, C. T. Shivannavar, N. G. Manjula   +4 more
openaire   +2 more sources

B1-Metallo-beta-Lactamases: Where do we stand?

Current Drug Targets, 2016
Metallo-beta-Lactamases (MBLs) are class B β-lactamases that hydrolyze almost all clinically-available β-lactam antibiotics. MBLs feature the distinctive αβ/βα sandwich fold of the metallo-hydrolase / oxidoreductase superfamily and possess a shallow ...
M. Mojica, R. Bonomo, W. Fast
semanticscholar   +1 more source

Three Component Thio‐ and Carboboration of Alkynes: A Modular Route to Functionalised Bicyclic Boronates

Angewandte Chemie, EarlyView.
Three‐component thio‐ and carbo‐boration reactions to form functionalised benzoxaborinines and benzazaborinines are reported. The nucleophile scope includes thioethers, thiols, and (hetero)arenes. Mechanistic studies revealed a disparity between thioboration using thioethers and using thiols.
Laura Winfrey, Gary S. Nichol, Stephen P. Thomas, Dominic R. Willcox, Michael. J. Ingleson   +4 more
wiley   +2 more sources

Extended Spectrum Beta-lactamases: Definition, Classification and Epidemiology.

Current Issues in Molecular Biology, 2015
Extended spectrum beta-lactamases (ESBLs) are defined as enzymes produced by certain bacteria that are able to hydrolyze extended spectrum cephalosporin.
S. Ghafourian, N. Sadeghifard, S. Soheili, Z. Sekawi   +3 more
semanticscholar   +1 more source

Ventilator-associated pneumonia in a tertiary care hospital in India: role of multi-drug resistant pathogens

Journal of Infection in Developing Countries, 2010
Background: Ventilator-Associated Pneumonia (VAP) is the most frequent intensive-care-unit (ICU)-acquired infection. The aetiology of VAP varies with different patient populations and types of ICUs.
Noyal Mariya Joseph, Sujatha Sistla, Tarun Kumar Dutta, Ashok Shankar Badhe, Desdemona Rasitha, Subhash Chandra Parija   +5 more
doaj   +1 more source

Extended-Spectrum Beta-Lactamases Producing Escherichia coli and Klebsiella pneumoniae: A Multi-Centric Study Across Karnataka

Journal of Laboratory Physicians, 2014
Background: There are sporadic reports on detection of extended-spectrum beta-lactamases (ESBL) producers from Karnataka; hence, this is a first multicentric study across Karnataka state to determine the prevalence of ESBL production among clinical ...
Sridhar P. Rao, P. S. Rama, Vishwanath Gurushanthappa, Radhakrishna Manipura, K. Srinivasan   +4 more
semanticscholar   +1 more source