Results 11 to 20 of about 597,070 (286)
Peptidase activity of beta-lactamases. [PDF]
The Biochemical journal, 1999 Although beta-lactamases have generally been considered as being devoid of peptidase activity, a low but significant hydrolysis of various N-acylated dipeptides was observed with representatives of each class of beta-lactamases. The kcat/Km values were below 0.1 M(-1).
Rhazi, Noureddine +3 more
openaire +4 more sources
Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases. [PDF]
PLoS Computational Biology, 2016 Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence ...
David Lee +5 more
doaj +2 more sources
Controversies about Extended-Spectrum and AmpC Beta-Lactamases [PDF]
Emerging Infectious Diseases, 2001 Many clinical laboratories have problems detecting extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated AmpC beta-lactamases. Confusion exists about the importance of these resistance mechanisms, optimal test methods, and appropriate reporting ...
Kenneth S. Thomson
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Evolution of metallo-beta-lactamases in focus of the antibiotic resistance problem [PDF]
Вісник Харківського Національного Університету Імені В.Н. Каразіна: Серія БіологіяThe article considers the place of metallo-beta-lactamases among the mechanisms of antibiotic resistance. These enzymes have important differences from serine beta-lactamases, which affect the mechanism of their catalytic activity, inhibition, rate of ...
V.B. Moskalov, I.V. Kadenko, A.M. Mukhin
doaj +3 more sources
Journal of Infection in Developing Countries, 2013 Introduction: Production of beta-lactamases is the predominant cause of resistance to beta-lactam antibiotics in Gram-negative bacteria. We investigated the diversity of plasmid-borne beta-lactamase genes and replicon type of the plasmids carrying the ...
David Olusoga Ogbolu +4 more
doaj +1 more source
Exposure assessment of extended-spectrum beta-lactamases/AmpC beta-lactamases-producing Escherichia coli in meat in Denmark [PDF]
, 2014 INTRODUCTION Extended-spectrum beta-lactamases (ESBL) and AmpC beta-lactamases (AmpC) are of concern for veterinary and public health because of their ability to cause treatment failure due to antimicrobial resistance in Enterobacteriaceae.
da Costa, Paulo M +6 more
core +1 more source
Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria
Frontiers in Microbiology, 2013 Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance.
Ximin eZeng, Jun eLin
doaj +1 more source
PLoS ONE, 2020 BackgroundExtended spectrum Beta-lactamases (ESBLs) and AmpC beta-lactamases (AmpC) are the common enzymes produced by gram negative bacilli, which are their main mechanisms of resistance to all generations of cephalosporins.
Saba Gebremichael Tekele +4 more
doaj +1 more source
Cefotaxime/sulbactam: clinical and pharmacological characteristics [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2019 The recently approved cefotaxime/sulbactam, combination of third-generation cephalosporin (cefotaxime) and beta-lactamase inhibitor (sulbactam), can combat resistance mechanisms associated with the production of serine beta-lactamases, including some ...
Ortenberg E.A., Golub A.V.
doaj +1 more source
Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains [PDF]
, 2011 Intestinal carriage of extended-spectrum beta-lactamase (ESBL) -producing bacteria in food-producing animals and contamination of retail meat may contribute to increased incidences of infections with ESBL-producing bacteria in humans.
Munckhof, M.P., Van den +11 more
core +1 more source