Results 11 to 20 of about 1,753,858 (323)
Evolution of metallo-beta-lactamases in focus of the antibiotic resistance problem
Вісник Харківського Національного Університету Імені В.Н. Каразіна: Серія БіологіяThe article considers the place of metallo-beta-lactamases among the mechanisms of antibiotic resistance. These enzymes have important differences from serine beta-lactamases, which affect the mechanism of their catalytic activity, inhibition, rate of ...
V.B. Moskalov, I.V. Kadenko, A.M. Mukhin
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Extended-spectrum beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1989 A, Philippon, R, Labia, G, Jacoby
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Occurrence of Carbapenemases, Extended-Spectrum Beta-Lactamases and AmpCs among Beta-Lactamase-Producing Gram-Negative Bacteria from Clinical Sources in Accra, Ghana [PDF]
Antibiotics, 2023 Noah Obeng-Nkrumah +2 more
exaly +2 more sources
Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu. +4 more
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Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1995 The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5.
S, Ohsuka +4 more
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Antimicrobial Agents and Chemotherapy, 2020 QPX7728 is a new ultrabroad-spectrum inhibitor of serine and metallo-beta-lactamases (MBLs) from a class of cyclic boronates that gave rise to vaborbactam.
Ruslan Tsivkovski +2 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2020 Despite major advances in the beta-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the Class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the Class D (OXA ...
S. Hecker +16 more
semanticscholar +1 more source
Al-Mustansiriyah Journal of Science, 2020 Background: Resistance to broad‑spectrum beta‑lactams, mediated by extended‑spectrum beta‑lactamases, and metallo‑beta‑lactamase enzymes, is an increasing problem worldwide.
Sakar Bakr Smail, Kamal I. AL-OTRACHI
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Annals of Mechnikov's Institute, 2022 The problem of the formation and spread of resistance to β-lactam antibiotics in clinically significant types of microorganisms is extremely important, since β-lactams traditionally form the basis of the treatment of bacterial infections.
Olena Peretyatko +4 more
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Journal of Infection in Developing Countries, 2013 Introduction: Production of beta-lactamases is the predominant cause of resistance to beta-lactam antibiotics in Gram-negative bacteria. We investigated the diversity of plasmid-borne beta-lactamase genes and replicon type of the plasmids carrying the ...
David Olusoga Ogbolu +4 more
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