An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains [PDF]
Microbiology Spectrum, 2022 Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human ...
Valérian Lupo +6 more
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Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding [PDF]
Nature Communications, 2023 There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast +13 more
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Extended-Spectrum Beta-Lactamases [PDF]
Canadian Journal of Infectious Diseases and Medical Microbiology, 2006 The definition of extended-spectrum beta-lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world.
Kevin R Forward
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Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases. [PDF]
PLoS Computational Biology, 2016 Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence ...
David Lee +5 more
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Peptidase activity of beta-lactamases. [PDF]
The Biochemical journal, 1999 Although beta-lactamases have generally been considered as being devoid of peptidase activity, a low but significant hydrolysis of various N-acylated dipeptides was observed with representatives of each class of beta-lactamases. The kcat/Km values were below 0.1 M(-1).
Rhazi, Noureddine +3 more
openaire +3 more sources
iMetaOmicsAntimicrobial resistance is a major global health threat shaped not only by clinical settings but also by environmental reservoirs, in line with the One Health framework.
José Coche‐Miranda +8 more
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, 2014 The OXA β-lactamases were among the earliest β-lactamases detected; however, these molecular class D β-lactamases were originally relatively rare and always plasmid mediated.
Benjamin A. Evans (3115968) +1 more
core +7 more sources
Occurrence of Carbapenemases, Extended-Spectrum Beta-Lactamases and AmpCs among Beta-Lactamase-Producing Gram-Negative Bacteria from Clinical Sources in Accra, Ghana [PDF]
Antibiotics, 2023 Noah Obeng-Nkrumah +2 more
exaly +2 more sources
Docking Study for New 7-Aminocephalosporinic Acid Derivatives as Potential Inhibitors for β-Lactamases [PDF]
المجلة العراقية للصيدلة, 2023 Background: Antibiotics with β-Lactam rings (β-Lactams), since they were discovered, have enhanced the typical treatment for bacterial infections.
Ahmed A. Saleh, Ahmed A. J. Mahmood
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Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu. +4 more
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