Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding [PDF]
Nature Communications, 2023 There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast +13 more
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Extended spectrum beta lactamases and carbapenemase-producing [PDF]
One HealthBackground: Antimicrobial resistance (AMR) is escalating in East Africa through close human-animal-environment interactions. Extended-spectrum beta-lactamases (ESBL) and carbapenemase-producing Escherichia coli are clinically critical pathogens, yet ...
Magreth Erick Macha +2 more
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An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains [PDF]
Microbiology Spectrum, 2022 Bacterial genes coding for antibiotic resistance represent a major issue in the fight against bacterial pathogens. Among those, genes encoding beta-lactamases target penicillin and related compounds such as carbapenems, which are critical for human ...
Valérian Lupo +6 more
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Antarctic soil microbiomes encode structurally conserved and phylogenetically diverse beta‐lactamases [PDF]
iMetaOmicsAntimicrobial resistance is a major global health threat shaped not only by clinical settings but also by environmental reservoirs, in line with the One Health framework.
José Coche‐Miranda +8 more
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Peptidase activity of beta-lactamases. [PDF]
The Biochemical journal, 1999 Although beta-lactamases have generally been considered as being devoid of peptidase activity, a low but significant hydrolysis of various N-acylated dipeptides was observed with representatives of each class of beta-lactamases. The kcat/Km values were below 0.1 M(-1).
Rhazi, Noureddine +3 more
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Evolution of metallo-beta-lactamases in focus of the antibiotic resistance problem [PDF]
Вісник Харківського Національного Університету Імені В.Н. Каразіна: Серія БіологіяThe article considers the place of metallo-beta-lactamases among the mechanisms of antibiotic resistance. These enzymes have important differences from serine beta-lactamases, which affect the mechanism of their catalytic activity, inhibition, rate of ...
V.B. Moskalov, I.V. Kadenko, A.M. Mukhin
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Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases. [PDF]
PLoS Computational Biology, 2016 Beta-lactamases represent the main bacterial mechanism of resistance to beta-lactam antibiotics and are a significant challenge to modern medicine. We have developed an automated classification and analysis protocol that exploits structure- and sequence ...
David Lee +5 more
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Extended-Spectrum Beta-Lactamases [PDF]
Canadian Journal of Infectious Diseases and Medical Microbiology, 2006 The definition of extended-spectrum beta-lactamases (ESBLs) has expanded rapidly, in terms of both the number and the variety of enzymes. Bacteria bearing plasmidic ESBLs are spreading widely throughout the world.
Kevin R Forward
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Docking Study for New 7-Aminocephalosporinic Acid Derivatives as Potential Inhibitors for β-Lactamases [PDF]
المجلة العراقية للصيدلة, 2023 Background: Antibiotics with β-Lactam rings (β-Lactams), since they were discovered, have enhanced the typical treatment for bacterial infections.
Ahmed A. Saleh, Ahmed A. J. Mahmood
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Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1995 The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5.
S, Ohsuka +4 more
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