Results 41 to 50 of about 827,661 (196)
Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily [PDF]
, 2007 peer reviewedOne strategy employed by bacterial strains to resist beta-lactam antibiotics is the expression of metallo-beta-lactamases requiring Zn+2 for activity.
Bebrone, Carine
core +1 more source
Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]
, 2006 Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core +1 more source
The impact of long-distance mutations on the Ω-loop conformation in TEM type β-lactamases
, 2019 β-lactamases are hydrolytic enzymes primarily responsible for occurrence and abundance of bacteria resistant to β-lactam antibiotics. TEM type β-lactamases are formed by the parent enzyme TEM-1 and more than two hundred of its mutants.
Dmitrii Shcherbinin (6881894) +4 more
core +1 more source
The Mechanisms of Catalysis by Metallo β-Lactamases [PDF]
, 2008 Class B β-lactamases or metallo-β-lactamases (MBLs) require zinc ions to catalyse the hydrolysis of β-lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins.
Michael I. Page +3 more
core +3 more sources
Kinetic properties of four plasmid-mediated AmpC beta-lactamases.
, 2005 peer reviewedThe heterologous production in Escherichia coli, the purification, and the kinetic characterization of four plasmid-encoded class C beta-lactamases (ACT-1, MIR-1, CMY-2, and CMY-1) were performed.
Bauvois, Cedric +6 more
core +1 more source
Successful Management of Urosepsis with Ceftriaxone+Sulbactam+EDTA: A Case Report of Penem Sparing Approach [PDF]
Journal of Clinical and Diagnostic Research, 2017 Over the past decade, the Anti-Microbial Resistance (AMR) among members of Enterobacteriaceae family is on rise mainly due to rapid spread of strains producing Extended-Spectrum Beta-Lactamases (ESBLs) and Metallo Beta-Lactamases (MBLs).
Amit Bery, Candy Sodhi, Rishu Bhanot
doaj +1 more source
The .BETA.-lactamases of genus Bacteroides.
The Journal of Antibiotics, 1983 Two hundred anaerobic isolates from clinical specimens were examined for beta-lactamase production by Nitrocefin methodology. Altogether, 77 strains were beta-lactamase producers. Organisms belonging to Bacteroides melaninogenicus group, i.e., B. intermedius and B.
M, Tajima, K, Sawa, K, Watanabe, K, Ueno
openaire +3 more sources
Scientific Reports, 2018 The objective of this study was to correlate resistance mutations of extended spectrum beta-lactamases (ESBL) and AmpC beta-lactamases and virulence factors (VF) with 30-day mortality in patients treated with either piperacillin-tazobactam or carbapenems.
Shi Thong Heng +4 more
doaj +1 more source
Infection and Drug Resistance, 2020 Upendra Thapa Shrestha,1,2,* Sabnum Shrestha,1,* Nabaraj Adhikari,1,2 Komal Raj Rijal,2 Basudha Shrestha,3 Bipin Adhikari,4 Megha Raj Banjara,2 Prakash Ghimire2 1Kantipur College of Medical Science, Tribhuvan University, Sitapaila, Kathmandu, Nepal ...
Thapa Shrestha U +7 more
doaj
«Checkerboard Array» as a Test for Evaluation of Decrease in Gram-Negative Bacteria Resistance to Carbapenems in the Presence of Bisphosphonate [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2015 One of the main mechanisms of resistance of Gramnegative microorganisms to antibiotics is enzymatic hydrolysis by beta-lactamases (for example, metallobeta-lactamases).
Afinogenova A.G. +3 more
doaj