Results 21 to 30 of about 827,661 (196)
Antimicrobial resistance of gram-negative pathogens isolated from hospitalized patients in Rostov region [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2020 Objective. To evaluate resistance rates to carbapenems and III–IV generation cephalosporins among gramnegative bacteria, including production of carbapenemases and extended-spectrum beta-lactamases (ESBL). Materials and Methods.
Kutsevalova O.Yu. +4 more
doaj +1 more source
Al-Mustansiriyah Journal of Science, 2020 Background: Resistance to broad‑spectrum beta‑lactams, mediated by extended‑spectrum beta‑lactamases, and metallo‑beta‑lactamase enzymes, is an increasing problem worldwide.
Sakar Bakr Smail, Kamal I. AL-OTRACHI
doaj +1 more source
Annals of Mechnikov's Institute, 2022 The problem of the formation and spread of resistance to β-lactam antibiotics in clinically significant types of microorganisms is extremely important, since β-lactams traditionally form the basis of the treatment of bacterial infections.
Olena Peretyatko +4 more
doaj +1 more source
Beta-lactam resistance in Campylobacter [PDF]
, 2011 Resistance to β-lactam antibiotics in Campylobacter is often associated with the production of a β-lactamase; to date the genomically encoded bla\(_{OXA-61}\) and the closely related cj0299 are the only described β-lactamase genes of Campylobacter ...
Stones, Leanne
core +7 more sources
Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases [PDF]
, 1999 peer reviewedThe most widely used inactivators of active-site serine beta-lactamases behave as substrates of four class B metallo-beta-lactamases, but the efficiency of the catalytic process can vary by several orders of magnitude.
Valladares, M. H. +15 more
core +1 more source
Journal of Infection in Developing Countries, 2013 Introduction: Production of beta-lactamases is the predominant cause of resistance to beta-lactam antibiotics in Gram-negative bacteria. We investigated the diversity of plasmid-borne beta-lactamase genes and replicon type of the plasmids carrying the ...
David Olusoga Ogbolu +4 more
doaj +1 more source
Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria
Frontiers in Microbiology, 2013 Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance.
Ximin eZeng, Jun eLin
doaj +1 more source
Cefotaxime/sulbactam: clinical and pharmacological characteristics [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2019 The recently approved cefotaxime/sulbactam, combination of third-generation cephalosporin (cefotaxime) and beta-lactamase inhibitor (sulbactam), can combat resistance mechanisms associated with the production of serine beta-lactamases, including some ...
Ortenberg E.A., Golub A.V.
doaj +1 more source
PLoS ONE, 2020 BackgroundExtended spectrum Beta-lactamases (ESBLs) and AmpC beta-lactamases (AmpC) are the common enzymes produced by gram negative bacilli, which are their main mechanisms of resistance to all generations of cephalosporins.
Saba Gebremichael Tekele +4 more
doaj +1 more source
Catalytic Properties of Class a Beta-Lactamases: Efficiency and Diversity [PDF]
, 1998 peer reviewedbeta-Lactamases are the main cause of bacterial resistance to penicillins, cephalosporins and related beta-lactam compounds. These enzymes inactivate the antibiotics by hydrolysing the amide bond of the beta-lactam ring.
Lamotte-Brasseur, Josette +2 more
core +1 more source