Breakthrough Advances in Beta-Lactamase Inhibitors: New Synthesized Compounds and Mechanisms of Action Against Drug-Resistant Bacteria [PDF]
PharmaceuticalsBeta-lactam drugs hold a central place in the antibacterial arsenal, and the production of beta-lactamases by drug-resistant bacteria has severely compromised the effectiveness of nearly all available beta-lactams.
Ya-Si Huang, Hong Zhou
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Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors [PDF]
Pharmacy, 2019 Although beta-lactam allergies are an emerging focus of stewardship programs and interventions, less is publicly released regarding allergies to beta-lactamase inhibitors. This review presents and evaluates the data regarding allergic reactions with beta-
Kayla R. Stover +2 more
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Inverse association between use of broad spectrum penicllin with beta-lactamase inhibitors and prevalence of type 1 diabetes mellitus in Europe [PDF]
Scientific Reports, 2021 Increasing incidence of type 1 diabetes is supposed to be induced by environmental factors. Microbiome modulated by antibiotics seems to serve as one of the environmental factors which could influence the development of T1DM.
Gábor Ternák +6 more
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Classification and applicability of new beta-lactamase inhibitors. [PDF]
Rev Esp QuimioterThis non-exhaustive mini review describes the main characteristics of the new beta-lactamase inhibitors (enmetazobactam, avibactam, relebactam, durlobactam, zidebactam, nacubactam, vaborbactam, taniborbactam, and xeruborbactam), their spectrum of inhibition, their activity in combination with different beta-lactams, the main resistance mechanisms that ...
Cercenado E, Candel FJ.
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Sporadic cefiderocol resistance in Escherichia coli from the United Arab Emirates involves multifactorial mechanisms reversible by novel beta-lactamase inhibitors [PDF]
Scientific ReportsCefiderocol (CFDC), a novel siderophore-cephalosporin, is effective against multidrug-resistant (MDR) pathogens, but the emergence of resistance threatens its future use in treating infections.
Farah Al-Marzooq +10 more
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Promising Future of Novel Beta-Lactam Antibiotics Against Bacterial Resistance [PDF]
Drug Design, Development and TherapySaeed M Tayeb,1 Jaser A Alharbi,1 Bushra B Alattas,1 Dana M Alotaibi,1 Nawaf M Althibaiti,1 Jaser F Alharbi,1 Ahmad E SafirAldeen,1 Ibrahim R Alqurashi,1 Saad M Wali2 1Pharmaceutical Sciences Department, College of Pharmacy, Umm Al-Qura University ...
Tayeb SM +8 more
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Old and New Beta-Lactamase Inhibitors: Molecular Structure, Mechanism of Action, and Clinical Use [PDF]
Antibiotics, 2021 Valerio Leoni +2 more
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Docking Study for New 7-Aminocephalosporinic Acid Derivatives as Potential Inhibitors for β-Lactamases [PDF]
المجلة العراقية للصيدلة, 2023 Background: Antibiotics with β-Lactam rings (β-Lactams), since they were discovered, have enhanced the typical treatment for bacterial infections.
Ahmed A. Saleh, Ahmed A. J. Mahmood
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The known-unknown: third- and fourth-generation cephalosporins combined with sulbactam [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections in ...
Stetsiouk O.U. +3 more
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Design, synthesis, and evaluation the anti-β-lactamase activity of new sulphathiazole-derived monobactam compounds [PDF]
المجلة العراقية للصيدلة, 2020 Objectives: β-Lactams are the most successful antibiotics for the management of infectious diseases. Unfortunately, the bacterial production of β-lactamase that hydrolyzes the β-lactam ring can inactivate these drugs.
Ahmed Mahmood +2 more
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