Results 11 to 20 of about 29,386 (262)

Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors [PDF]

Pharmacy, 2019
Although beta-lactam allergies are an emerging focus of stewardship programs and interventions, less is publicly released regarding allergies to beta-lactamase inhibitors. This review presents and evaluates the data regarding allergic reactions with beta-
Kayla R. Stover, Katie E. Barber, Jamie L. Wagner   +2 more
doaj   +2 more sources

Sporadic cefiderocol resistance in Escherichia coli from the United Arab Emirates involves multifactorial mechanisms reversible by novel beta-lactamase inhibitors [PDF]

Scientific Reports
Cefiderocol (CFDC), a novel siderophore-cephalosporin, is effective against multidrug-resistant (MDR) pathogens, but the emergence of resistance threatens its future use in treating infections.
Farah Al-Marzooq, Hafsa Ahli, Rauda Aldhaheri, Omar Aleissaee, Abdulrahman Alzaabi, Abdullah Alsaadi, Hamad Almansoori, Akela Ghazawi, Lana Daoud, Amna Ahmad, Timothy Collyns   +10 more
doaj   +2 more sources

Classification and applicability of new beta-lactamase inhibitors [PDF]

Revista Española de Quimioterapia
This non-exhaustive mini review describes the main characteristics of the new beta-lactamase inhibitors (enmetazobactam, avibactam, relebactam, durlobactam, zidebactam, nacubactam, vaborbactam, taniborbactam, and xeruborbactam), their spectrum of inhibition, their activity in combination with different beta-lactams, the main resistance mechanisms that ...
Emilia Cercenado, Francisco Javier Candel   +1 more
openaire   +3 more sources

Zwitterionic Penicillin-Derived Sulfone Inhibitor for Combating β-Lactamase-Mediated Antibiotic Resistance. [PDF]

ChemMedChem
Combining enhanced permeability strategies with (2‐pyridyl)methylene substitution in the sulbactam scaffold led to a novel β‐lactamase inhibitor to combat β‐lactamase‐mediated resistance to β‐lactam antibiotics. The studies presented highlight the potential of compound 3 as a next‐generation β‐lactamase inhibitor for combating infections caused by ...
Rodríguez D, Lence E, Vázquez-Ucha JC, Beceiro A, González-Bello C.   +4 more
europepmc   +2 more sources

Promising Future of Novel Beta-Lactam Antibiotics Against Bacterial Resistance [PDF]

Drug Design, Development and Therapy
Saeed M Tayeb,1 Jaser A Alharbi,1 Bushra B Alattas,1 Dana M Alotaibi,1 Nawaf M Althibaiti,1 Jaser F Alharbi,1 Ahmad E SafirAldeen,1 Ibrahim R Alqurashi,1 Saad M Wali2 1Pharmaceutical Sciences Department, College of Pharmacy, Umm Al-Qura University ...
Tayeb SM, Alharbi JA, Alattas BB, Alotaibi DM, Althibaiti NM, Alharbi JF, SafirAldeen AE, Alqurashi IR, Wali SM   +8 more
doaj   +2 more sources

Correlation Between Antimicrobial Consumption and Resistance in Klebsiella pneumoniae During the COVID-19 Pandemic Using Dynamic Regression Models: A Quasi-Experimental Epidemiological Time-Series Study [PDF]

Antibiotics
Background/Objectives: The COVID-19 pandemic has been reported to impact antimicrobial consumption (AMC) and antimicrobial resistance (AMR) worldwide. We aimed to assess this correlation in Klebsiella pneumoniae before and during the COVID-19 pandemic ...
Paul Laffont-Lozes, Florian Salipante, Paul Loubet, Catherine Dunyach-Remy, Jean-Philippe Lavigne, Albert Sotto, Romaric Larcher   +6 more
doaj   +2 more sources

Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Nature Communications, 2020
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al.
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony   +8 more
doaj   +1 more source

Effect of β-lactamase inhibitors on in vitro activity of β-lactam antibiotics against Burkholderia cepacia complex species [PDF]

, 2016
Background: Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients. Intrinsic resistance to a wide range of antimicrobial agents, including a variety of beta-
Coenye, Tom, Everaert, Annelien
core   +2 more sources

Production of β-Lactamase Inhibitors by Streptomyces Species

Antibiotics, 2018
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials and β-lactamase ...
Daniela de Araújo Viana Marques, Suellen Emilliany Feitosa Machado, Valéria Carvalho Santos Ebinuma, Carolina de Albuquerque Lima Duarte, Attilio Converti, Ana Lúcia Figueiredo Porto   +5 more
doaj   +1 more source

Broad-spectrum β-lactamases among Enterobacteriaceae of animal origin: molecular aspects, mobility and impact on public health [PDF]

, 2010
Broad-spectrum β-lactamase genes (coding for extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases) have been frequently demonstrated in the microbiota of food-producing animals. This may pose a human health hazard since these genes may be present
Butaye, Patrick, Dewulf, Jeroen, Haesebrouck, Freddy, Herman, Lieve, Heyndrickx, Marc, Martel, An, Persoons, Davy, Smet, Annemieke   +7 more
core   +1 more source