Results 11 to 20 of about 1,353,519 (253)

Beta-Lactamase Inhibitors

, 2022
Archive of beta-lactamase-inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Khanna NR, Gerriets V.
europepmc   +4 more sources

Production of β-Lactamase Inhibitors by Streptomyces Species

Antibiotics, 2018
β-Lactamase inhibitors have emerged as an effective alternative to reduce the effects of resistance against β-lactam antibiotics. The Streptomyces genus is known for being an exceptional natural source of antimicrobials and β-lactamase ...
Daniela de Araújo Viana Marques, Suellen Emilliany Feitosa Machado, Valéria Carvalho Santos Ebinuma, Carolina de Albuquerque Lima Duarte, Attilio Converti, Ana Lúcia Figueiredo Porto   +5 more
doaj   +2 more sources

Clinical Outcomes of Non-carbapenem Treatment for Urinary Tract Infections Caused by Extended-spectrum β-lactamase-producing [PDF]

Childhood Kidney Diseases, 2021
Purpose The purpose of this study was to investigate the clinical outcomes of non-carbapenem treatment for urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) in young children.
Eunae Kim, Yo Han Ahn, Jung Won Lee, Eujin Park   +3 more
doaj   +1 more source

Treatment in Infections by Enterobacterales Producing Extended Spectrum Betalactamase. Systematic Review

Kasmera, 2021
Extended spectrum beta-lactamases producing Enterobacterales have become pandemic worldwide representing a major public health threat due to poor outcomes and high mortality associated with infections by these bacteria, consequently it is essential to ...
Carli Samira Aziz Delgado, José Andrés Mendoza Gaviria   +1 more
doaj   +1 more source

Functional Dynamics of Substrate Recognition in TEM Beta-Lactamase

Entropy, 2022
The beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem.
Chris Avery, Lonnie Baker, Donald J. Jacobs   +2 more
doaj   +1 more source

Escape mutations circumvent a tradeoff between resistance to a beta-lactam and resistance to a beta-lactamase inhibitor

Nature Communications, 2020
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al.
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony   +8 more
doaj   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs

Frontiers in Microbiology, 2021
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for an immediate search for novel treatment strategies.
Sourya Bhattacharya, Vivek Junghare, Niteesh Kumar Pandey, Subhecchha Baidya, Harsha Agarwal, Neeladrisingha Das, Ayan Banerjee, Ayan Banerjee, Debashish Ghosh, Debashish Ghosh, Partha Roy, Hirak K. Patra, Saugata Hazra, Saugata Hazra   +13 more
doaj   +1 more source

Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates

, 2022
With the emergence and rapid spreading of NDM-1 and existence of clinically relevant VIM-1 and IMP-1, discovery of pan inhibitors targeting metallo-beta-lactamases (MBLs) became critical in our battle against bacterial infection.
Winnie Prosise (14231582), Shu-Wei Yang (2351068), Alex G. Therien (10156446), Weidong Pan (1427614), Giovanna Scapin (1427611), Christine Yang (149071), Li Xiao (307908), Jianping Pan (5473910), Amy Flattery (1349508), Thierry Fischmann (1586191), Alexander Pasternak (161010), Mihirbaran Mandal (2026381), Priya Dayananth (1720108), Todd W. Mayhood (2383978), Alexei V. Buevich (1433287), Katherine Young (526710), Jim Tata (1463734), Carrie Markgraf (14231588), Jacqueline D. Hicks (2335909), Nicholas Murgolo (1349487), Reynalda Keh de Jesus (14231579), Asra Mirza (1427602), Payal Sheth (3875491), Haifeng Tang (488592), Jin Wu (216487), Todd Black (1882981), Jing Su (23377), Yuriko Root (14231576), Rumin Zhang (2729599), Shuzhi Dong (2352922), Emma R. Parmee (298242), Haiqun Tang (2127373), Daniel F. Wyss (2177280), Inhou Chu (2026375), Charles Garlisi (4397194), Hai-Young Kim (156469), Lianzhu Liang (2276707), William K. Hagmann (1370268), Donald Chu (14231585), Artjohn Villafania (6917033), Guoqing Li (23674), Ronald Painter (2646250), Edward DiNunzio (12293994), Ann E. Weber (1416991)   +43 more
core   +2 more sources

Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria

Journal of Biomedical Science, 2019
Background This study sought to develop new strategies for reverting the resistance of pathogenic Gram-negative bacilli by a combination of conventional antibiotics, potent permeabilizers and natural beta lactamase inhibitors enhancing the activity of ...
Hala A. Farrag, Nagwa Abdallah, Mona M. K. Shehata, Ebthag M. Awad   +3 more
doaj   +1 more source