Results 41 to 50 of about 29,386 (262)

In vitro activity of ceftazidime/avibactam against carbapenem-nonsusceptible Klebsiella penumoniae isolates collected during the first wave of the SARS-CoV-2 pandemic: a Southern Italy, multicenter, surveillance study

Journal of Global Antimicrobial Resistance, 2022
Objectives: Carbapenemase-producing Enterobacterales (CPE) represent a serious threat for human health being frequently resistant to most of available antibiotics classes.
Gianfranco La Bella, Teresa Lopizzo, Laura Lupo, Rosa Angarano, Anna Curci, Barbara Manti, Giovanna La Salandra, Adriana Mosca, Rosella De Nittis, Fabio Arena   +9 more
doaj   +1 more source

Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs) [PDF]

, 2015
BlaC, the single chromosomally-encoded β-lactamase of Mycobacterium tuberculosis, has been identified as a promising target for novel therapies that rely upon β-lactamase inhibition.
Bethel, Christopher R., Blanchard, John S., Bonomo, Robert A., CASELLI, Emilia, Hazra, Saugata, Kurz, Sebastian G., PRATI, Fabio, ROMAGNOLI, Chiara   +7 more
core   +1 more source

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +1 more source

Klebsiella pneumoniae Susceptibility to Carbapenem/Relebactam Combinations: Influence of Inoculum Density and Carbapenem-to-Inhibitor Concentration Ratio

Biomedicines, 2022
The inoculum effect (IE) is a well-known phenomenon with beta-lactams. At the same time, the IE has not been extensively studied with carbapenem/carbapenemase inhibitor combinations.
Maria V. Golikova, Kamilla N. Alieva, Alla V. Filimonova, Vladimir A. Ageevets, Ofeliia S. Sulian, Alisa A. Avdeeva, Sergey V. Sidorenko, Stephen H. Zinner   +7 more
doaj   +1 more source

Antibiotic prophylaxis is associated with subsequent resistant infections in children with an initial extended-spectrum-cephalosporin-resistant Enterobacteriaceae infection [PDF]

, 2017
The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin ...
Adler, Amanda L, Burnham, Carey-Ann D, Das, Sibani, Elward, Alexis, Kronman, Matthew P, Miles-Jay, Arianna, Newland, Jason G, Qin, Xuan, Selvarangan, Rangaraj, Sullivan, Kaede V, Weissman, Scott J, Zaoutis, Theoklis, Zerr, Danielle M   +12 more
core   +2 more sources

Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]

, 2018
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J., Guerra, B., Rodicio Rodicio, María del Rosario   +2 more
core   +3 more sources

Carbapenem-sparing beta-lactam/beta-lactamase inhibitors versus carbapenems for bloodstream infections caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae: a systematic review and meta-analysis

International Journal of Infectious Diseases, 2023
Objectives: Bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) have become a worldwide public health threat, and beta-lactam/beta-lactamase inhibitor combinations (BLBLIs) are considered as one
Huan Zhang, Juan Xu, Qinyan Xiao, Yuhang Wang, Jin Wang, Man Zhu, Yun Cai   +6 more
doaj   +1 more source

Phylogeny, Resistome, and Virulome of Escherichia coli Causing Biliary Tract Infections [PDF]

, 2019
Escherichia coli is the most frequent Gram-negative bacilli involved in intra-abdominal infections. However, despite high mortality rates associated with biliary tract infections due to E. coli, there is no study focusing on this pathogen. In this study,
Aznar Martín, Javier, Bonnin, Rémy A., Lepe, José A., Naas, Thierry, Ortiz de la Rosa, José Manuel, Pachón, Jerónimo, Rodríguez-Villodres, Ángel, Smani, Younes, Álvarez-Marín, Rocío   +8 more
core   +2 more sources

Cefonicid: A stable .BETA.-lactamase inhibitor.

The Journal of Antibiotics, 1981
The stability of cefonicid (SK&F 75073) towards representatives of six major classes of beta-lactamases was determined using a spectrophotometric assay. Cefonicid was stable to hydrolysis by the Type I enzyme from Enterobacter cloacae and by the enzyme from the anaerobe, Bacteroides fragilis. It was 6 to 7 times more stable than cefamandole to the Type
R J, Mehta, D J, Newman, B A, Bowie, C H, Nash, P, Actor   +4 more
openaire   +3 more sources

Nanozymes as Enzyme Inhibitors

International Journal of Nanomedicine, 2021
Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key ...
Huang Y, Jiang J, Wang Y, Chen J, Xi J
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