Results 41 to 50 of about 34,488 (237)
Nature Communications, 2023 There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast +13 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2022 Objectives: Carbapenemase-producing Enterobacterales (CPE) represent a serious threat for human health being frequently resistant to most of available antibiotics classes.
Gianfranco La Bella +9 more
doaj +1 more source
Cefonicid: A stable .BETA.-lactamase inhibitor.
The Journal of Antibiotics, 1981 The stability of cefonicid (SK&F 75073) towards representatives of six major classes of beta-lactamases was determined using a spectrophotometric assay. Cefonicid was stable to hydrolysis by the Type I enzyme from Enterobacter cloacae and by the enzyme from the anaerobe, Bacteroides fragilis. It was 6 to 7 times more stable than cefamandole to the Type
R J, Mehta +4 more
openaire +3 more sources
Approachable Synthetic Methodologies for Second-Generation β-Lactamase Inhibitors: A Review [PDF]
Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) have been produced.
Noor Fatima +7 more
core +1 more source
The ideal patient profile for new beta-lactam/beta-lactamase inhibitors [PDF]
, 2018 PURPOSE OF REVIEW: The worldwide spread of extended-spectrum beta-lactamase (ESBL)-producing bacteria, the overuse of carbapenems, the emergence of carbapenemase-producing organisms and the growing importance of multidrug-resistant and/or extended drug ...
Montravers, Philippe +3 more
core +1 more source
International Journal of Infectious Diseases, 2023 Objectives: Bloodstream infections (BSIs) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) have become a worldwide public health threat, and beta-lactam/beta-lactamase inhibitor combinations (BLBLIs) are considered as one
Huan Zhang +6 more
doaj +1 more source
In Vitro Susceptibilities of Capnocytophaga Isolates to β-Lactam Antibiotics and β-Lactamase Inhibitors [PDF]
, 2000 The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method.
Michel Cormier +6 more
core +1 more source
Diketene analogs as .BETA.-lactamase inhibitor.
Chemical and Pharmaceutical Bulletin, 1989 Compounds having a structural analogy with diketene have been synthesized and their potencies as beta-lactamase inhibitors have been studied. Among six compounds so far tested, alpha-phenyl-beta-benzylidene-3-propanolide was shown to be an irreversible inhibitor of the enzyme. The availability of simple monocyclic compounds as beta-lactamase inhibitors
YANIZAWA, Kazutaka +2 more
openaire +3 more sources
Advanced Science, EarlyView.High‐throughput antibiotic cross‐gradient assays on microdroplet arrays. A multichannel printhead together with five pressure regulators forms droplet arrays of up to 20 832 droplets within 25 minutes. Each droplet contains unique concentrations of antibiotics, allowing to moniture a vast spectrum of bacterial repsonses over night. The bacterial growth
M. Breitfeld +5 more
wiley +1 more source
Cyclobutanone analogues of beta‐lactam antibiotics: beta‐lactamase inhibitors with untapped potential? [PDF]
, 2016 Beta‐Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial resistance to beta‐lactams: the ...
Rutledge, Peter J +3 more
core +1 more source