Results 51 to 60 of about 34,488 (237)

Nanozymes as Enzyme Inhibitors

International Journal of Nanomedicine, 2021
Yaling Huang,1 Jian Jiang,1 Yanqiu Wang,1 Jie Chen,1 Juqun Xi1,2 1Institute of Translational Medicine, Department of Pharmacology, School of Medicine, Yangzhou University, Yangzhou, Jiangsu, 225001, People’s Republic of China; 2Jiangsu Key ...
Huang Y, Jiang J, Wang Y, Chen J, Xi J
doaj  

Asymmetric Single‐Atom Catalysts Govern Diffusible and Non‐Diffusible Non‐Radical Pathways for Selective Degradation of Antibiotic Resistance Genes

Advanced Science, EarlyView.
Asymmetric single‐atom metal‐nitrogen‐carbon catalysts modulate the non‐radical pathway during peroxymonosulfate (PMS) activation. A fundamental contrast was revealed between diffusible singlet oxygen (1O2) and non‐diffusible electron‐transfer pathways (ETP) in antibiotic resistance gene (ARG) degradation.
Chen Gao, Jun Sun, Liang Zhang, Litao Lin, Zongfeng Wan, Bingcai Pan, Sheng Tang   +6 more
wiley   +1 more source

Structure based drug design: the discovery of novel inhibitors active against New Delhi Metallo-β-lactamase-1 [PDF]

, 2017
Background. The emergence of bacterial strains resistant to available antibiotic armamentarium is nowadays a pressing issue in clinical therapy. Among the several mechanisms of bacterial resistance, the rapid evolution and spread of carbapenemases, β ...
Cross, Simon, Perilli, Mariagrazia, Celenza, Giuseppe, Cendron, Laura, TONDI, Donatella, Bellio, Pierangelo, SPYRAKIS, FRANCESCA, Marcoccia, Francesca   +7 more
core  

Innovative Test Strip‐Based Colorimetric Sensors Integrated With Affinity Chromatography: Acetylcholinesterase Inhibitor Screening Breakthrough in Lycium Barbarum Leaves

Advanced Science, EarlyView.
Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa, Hui Yuan, Jingui Ma, Zhigang Yang, Mei Wang, Weibiao Wang, Lingling Yang, Fen Ma, Weiman Zhang, Gidion Wilson Mening'oo, Guoning Chen, Xueqin Ma   +11 more
wiley   +1 more source

Synthesis and rearrangement of potential zinc beta-lactamase inhibitors. [PDF]

, 1995
On alkylation of the p-toluene sulfonic salt of benzyl 6-aminopenicillanate (6-APA) with benzyl 2-bromoacetate, the benzyl esters of N-(benzyloxycarbonylmethyl)-6-APA (1) and of N,N-di(benzyloxycarbonylmethyl)-6-APA (3) were obtained. Hydrogenolysis of 1
Vanwetswinkel, S., Van Hove, François, Marchand-Brynaert, Jacqueline, Fastrez, Jacques   +3 more
core   +1 more source

The investigation of the new beta-lactamase inhibitors [PDF]

New Biotechnology, 2009
Klinikte kullanımda olan beta-laktamazları geri dönüşümsüz olarak inhibe eden 3 farklı inhibitör söz konusudur; bunlar klavulanik asit, sulbaktam ve tazobaktamdır.
H. Karaca, Y. Tunali, S. Korkmaz, Y. Ozturk   +3 more
openaire   +3 more sources

In vitro and in silico screening of Klebsiella pneumoniae new Delhi metallo-β-lactamase-1 inhibitors from endophytic Streptomyces spp. [PDF]

, 2021
The increase in drug resistance over the last two decades is a big threat in health care settings. More importantly, the dissemination of carbapenem-resistant Enterobacteriaceae is the major threat to public health with an increase in morbidity and ...
Aathithya Diaz (11572536), Sudarshan Singh Rathore (6406109), Adithya Conjeevaram Gopal (11572539), Jayapradha Ramakrishnan (6406115), Lalitha Cheepurupalli (6406106), Vigneshwar Ramakrishnan (3388904)   +5 more
core   +1 more source

Probing the Role of Asn 152 in the Class C β-lactamase AmpC [PDF]

, 2012
AmpC, a class C β-lactamase, is a main cause of antibiotic resistance to cephalosporins in many species of bacteria. The current proposed mechanism of action involves an acyl-intermediate, where the enzyme becomes covalently attached to the drug at ...
Powers, Rachel, Leonard, David, Anwar, Mujahid, Docter, Brianne, Wallar, Bradley   +4 more
core   +1 more source

Fluoroquinolones versus beta-Lactam/beta-Lactamase Inhibitors in Outpatients with Chronic Obstructive Pulmonary Disease and Pneumonia: A Nationwide Population-Based Study [PDF]

, 2017
Background ;Studies on the association between antibiotic treatment and outcomes in outpatients with chronic obstructive pulmonary disease (COPD) and pneumonia are scarce. This study aimed to evaluate the effectiveness of fluoroquinolones and beta-lactam/
Lin, Kuan-Yin;Wang, Chi-Chuan;Lin, Chia-Hui;Sheng, Wang-Huei;Chang, Shan-Chwen, 張上淳;王繼娟;盛望徽   +1 more
core   +1 more source

Antimicrobial susceptibility pattern of extended-spectrum beta- lactamase producing Klebsiella pneumoniae clinical isolates in an Indian tertiary hospital

Journal of Research in Pharmacy Practice, 2015
Objective: There is an increased prevalence of extended-spectrum beta-lactamase producing Klebsiella pneumoniae (ESBL-KP) worldwide including India, which is a major concern for the clinicians, especially in intensive care units and pediatric patients ...
Amit Kumar Singh, Sonali Jain, Dinesh Kumar, Ravinder Pal Singh, Hitesh Bhatt   +4 more
doaj   +1 more source