Results 71 to 80 of about 1,353,519 (253)
Small Methods, EarlyView.A filtration‐assisted SERS platform integrating in situ gold growth within the bacterial microenvironment enables rapid and highly sensitive detection of low‐level bacteria in complex biological matrices. By overcoming hotspot–bacteria mismatch, the platform simultaneously achieves selective bacterial identification and rapid antimicrobial ...
Eun‐Bi Jang +3 more
wiley +1 more source
Beta-lactamase inhibitors - an effective way to combat antibiotic resistance [PDF]
Introducere. Creşterea rezistenţei microbilor la antibiotice constituie o problemă de sănătate publică. Una din cauzele majore ale rezistenţei la beta-lactamine s-a raportat a fi producerea de beta-lactamaze.
Lehevici, Ion
core +1 more source
, 2013 Christine Miossec, Monique Claudon, Premavathy Levasseur, Michael T Black Novexel, Romainville, France Abstract: Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as ...
Black MT +3 more
core
Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase
, 2004 With the aim of improving the ability of non-p-lactam inhibitors to inhibit AmpC-beta-tactamase, a series of 3-aza-phenyl-boronic acid derivatives was obtained using in parallel synthesis.
S. Calo +5 more
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Integrative Zoology, EarlyView.ABSTRACT Malayan pangolin populations have fallen to a critically endangered level, and illegal trafficking of wild pangolins is a global problem. Little is known about antimicrobial‐resistant bacteria (MDRB) harbored by pangolins, although pangolins are frequently consumed as food or used in traditional medicine. In this study, we report for the first
Yawen Wang +8 more
wiley +1 more source
Approachable Synthetic Methodologies for Second-Generation β-Lactamase Inhibitors: A Review
Some antibiotics that are frequently employed are β-lactams. In light of the hydrolytic process of β-lactamase, found in Gram-negative bacteria, inhibitors of β-lactamase (BLIs) have been produced.
Noor Fatima +7 more
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Acta Paediatrica, EarlyView.ABSTRACT Aim We retrospectively evaluated trends in antimicrobial resistance (AMR) in paediatric bloodstream infections and assessed changes in antimicrobial prescription patterns over a 20‐year period. Methods We analysed positive blood cultures from children admitted with suspected serious infection between 1998 and 2018.
Joachim Luthander +5 more
wiley +1 more source
Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)
Australian Veterinary Journal, EarlyView.Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
THE NEW METALL-BETA-LACTAMASE’S INHIBITOR EFFICACY IN A MODEL SYSTEM IN VITRO
Инфекция и иммунитет, 2017 The Enterobacteriaceae antibiotics resistance depends on a combination of several mechanisms, such as the beta-lactamases overproduction, the microbial cell reduction outer membrane permeability (usually associated with loss of protein porin), the ...
A. G. Afinogenova +3 more
doaj +1 more source