Results 91 to 100 of about 1,353,519 (253)

Dynamic combinatorial mass spectrometry leads to metallo-beta-lactamase inhibitors.

, 2008
The use of protein ESI mass spectrometry under non-denaturing conditions to analyze a dynamic combinatorial library of thiols/disulfides with the BcII metallo-beta-lactamase enabled the rapid identification of an inhibitor with a K(i) of < 1 microM.
Lassaux, Patricia, Frère, JM, Huting, Rebekka, Lassaux, P, Galleni, M, Hüting, R, Galleni, Moreno, Liénard, BM, Schofield, Christopher J., Frère, Jean-Marie, Schofield, CJ, Schofield, Christopher, Lienard, Benoit M. R.   +12 more
core   +1 more source

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus

mLife, EarlyView.
Shuai Wang, Md Shah Alam, Buhari Yusuf, Jingran Zhang, Ziwen Lu, Xiaofan Zhang, H. M. Adnan Hameed, Mst. Sumaia Khatun, Chunyu Li, Lijie Li, Aleksey A. Vatlin, Aweke M. Belachew, Xirong Tian, Yamin Gao, Cuiting Fang, Rogers P. Zhang, Jun Li, Xinyue Wang, Liqiang Feng, Li Wan, Tianyu Zhang   +20 more
wiley   +1 more source

Cefonicid: A stable .BETA.-lactamase inhibitor.

The Journal of Antibiotics, 1981
The stability of cefonicid (SK&F 75073) towards representatives of six major classes of beta-lactamases was determined using a spectrophotometric assay. Cefonicid was stable to hydrolysis by the Type I enzyme from Enterobacter cloacae and by the enzyme from the anaerobe, Bacteroides fragilis. It was 6 to 7 times more stable than cefamandole to the Type
R J, Mehta, D J, Newman, B A, Bowie, C H, Nash, P, Actor   +4 more
openaire   +3 more sources

The ideal patient profile for new beta-lactam/beta-lactamase inhibitors

, 2018
PURPOSE OF REVIEW: The worldwide spread of extended-spectrum beta-lactamase (ESBL)-producing bacteria, the overuse of carbapenems, the emergence of carbapenemase-producing organisms and the growing importance of multidrug-resistant and/or extended drug ...
Montravers, Philippe, Bassetti M., Bassetti, Matteo, Montravers P.   +3 more
core   +1 more source

MICROBIOLOGICAL CHARACTERIZATION OF THE BACTERIAL FLORA IN PATIENTS WITH PHLEGMON OF THE MAXILLOFACIAL SCOPE

Кубанский научный медицинский вестник, 2016
The study describes the microbiological state of the patients with phlegmon of the maxillofacial scope. Most of the samples contained Staphylococcus aureus (52,63%).
S. . Gumenyuk, O. A. Kachanova, T. V. Gaivoronskaya, S. E. Gumenyuk, S. K. Shafranova, V. M. Bensman   +5 more
doaj  

Phenotypic and genomic characterization of Roseomonas mucosa, an opportunistic pathogen with discrepancies among antimicrobial susceptibility testing methods

Antimicrobial Agents and Chemotherapy
Roseomonas mucosa is an opportunistic bacterium found in clinical and environmental samples that primarily affects immunocompromised patients. Treatment is challenging owing to the lack of standardized susceptibility testing methods, breakpoints, and ...
Camille Cotet, Sebastien Galopin, Anne-Emeline Creach, Marwan Tenouri, Charlotte Le Pont, Nathalie Laquay, Jean-Christophe Giard, Simon Le Hello, François Gravey   +8 more
doaj   +1 more source

Novel and emerging antimicrobial strategies in the management of oral infections

Periodontology 2000, EarlyView.
Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley   +1 more source

Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales

Infection and Drug Resistance, 2021
Xing Tan,1 Hwan Seung Kim,1 Kimberly Baugh,2 Yanqin Huang,1 Neeraja Kadiyala,1 Marisol Wences,1 Nidhi Singh,1 Eric Wenzler,1 Zackery P Bulman1 1Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA ...
Tan X, Kim HS, Baugh K, Huang Y, Kadiyala N, Wences M, Singh N, Wenzler E, Bulman ZP   +8 more
doaj  

Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation

Frontiers in Microbiology, 2018
Acinetobacter nosocomialis is a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. Increasingly, reports are emerging of the pathogenic profile and multidrug resistance (MDR) phenotype of this species.
Daniel B. Knight, Susan D. Rudin, Susan D. Rudin, Susan D. Rudin, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Philip N. Rather, Philip N. Rather, Philip N. Rather   +9 more
doaj   +1 more source

ARC in Critical Ill OLT Recipients: True Prevalence, Risk Factors, and Impact on Early Aggressive PK/PD Target Non‐Attainment of CI Beta‐Lactam Therapy for Posttransplant Gram‐Negative Infections

Transplant Infectious Disease, EarlyView.
Augmented renal clearance (ARC) represents a quite prevalent condition among critical orthotopic liver transplant recipients (23.2%). ARC is associated with different demographics and clinical features and significantly affects the attainment of aggressive beta‐lactams pharmacokinetic/pharmacodynamic targets despite the administration of standard ...
Milo Gatti, Riccardo De Paola, Matteo Rinaldi, Cristiana Laici, Antonio Siniscalchi, Pierluigi Viale, Federico Pea   +6 more
wiley   +1 more source