Results 91 to 100 of about 34,488 (237)
A multidisciplinary approach to the design of novel inhibitors for KPC-2 [PDF]
, 2017 Background. The emergence and dissemination of multi drug resistant (MDR) Gram-negative pathogens resistant to all available antibiotics poses a significant threat in clinical therapy.
Perilli, Mariagrazia +5 more
core
Acta Paediatrica, EarlyView.ABSTRACT Aim We retrospectively evaluated trends in antimicrobial resistance (AMR) in paediatric bloodstream infections and assessed changes in antimicrobial prescription patterns over a 20‐year period. Methods We analysed positive blood cultures from children admitted with suspected serious infection between 1998 and 2018.
Joachim Luthander +5 more
wiley +1 more source
The effect of a beta-lactamase inhibitor peptide on bacterial membrane structure and integrity: a comparative study [PDF]
, 2017 Co-administration of beta-lactam antibiotics and beta-lactamase inhibitors has been a favored treatment strategy against beta-lactamase-mediated bacterial antibiotic resistance, but the emergence of beta-lactamases resistant to current inhibitors ...
SARIYAR AKBULUT, BERNA
core +4 more sources
Carriage of antimicrobial‐resistant E. coli in urban stray cats (Felis catus)
Australian Veterinary Journal, EarlyView.Antimicrobial resistance (AMR) in Escherichia coli is a growing concern in both human and veterinary medicine, driven by the inappropriate use of antimicrobials. Companion animals may act as community reservoirs and sentinels for antimicrobial‐resistant bacteria due to their close contact with humans and other animals.
JS Kuan, S Mukerji, D Hampson, S Abraham
wiley +1 more source
STRUCTURAL AND KINETIC CHARACTERIZATION OF A BETA-LACTAMASE-INHIBITOR PROTEIN [PDF]
, 1994 peer reviewedTHE past decade has seen an alarming worldwide increase in resistance to beta-lactam antibiotics among many pathogenic bacteria1, which is due mainly to plasmid- or chromosomally encoded beta-lactamases that specifically cleave penicillin ...
André Matagne +15 more
core +1 more source
THE NEW METALL-BETA-LACTAMASE’S INHIBITOR EFFICACY IN A MODEL SYSTEM IN VITRO
Инфекция и иммунитет, 2017 The Enterobacteriaceae antibiotics resistance depends on a combination of several mechanisms, such as the beta-lactamases overproduction, the microbial cell reduction outer membrane permeability (usually associated with loss of protein porin), the ...
A. G. Afinogenova +3 more
doaj +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Beta-lactamase inhibitors - an effective way to combat antibiotic resistance [PDF]
Introducere. Creşterea rezistenţei microbilor la antibiotice constituie o problemă de sănătate publică. Una din cauzele majore ale rezistenţei la beta-lactamine s-a raportat a fi producerea de beta-lactamaze.
Lehevici, Ion
core
Structure-based optimization of cephalotin analogue boronic acids as beta-lactamase inhibitors [PDF]
, 2007 Boronic acids have proved to be promising selective inhibitors of beta-lactamases, acting as transition state analogues. Starting from a previously described nanomolar inhibitor of AmpC beta-lactamase, three new inhibitors were designed to gain ...
MORANDI, Stefania +9 more
core +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Background Primary or persistent endodontic disease is caused by microbial biofilms that irritate the pulp and periapical tissues. Extensive microbiological analyses of these biofilms and their constituent pathogens have revealed their diversity and complexity.
Ashraf F. Fouad
wiley +1 more source