A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment [PDF]
, 2016 published_or_final_versio
Chau, PH +11 more
core +1 more source
Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis
BJU International, EarlyView.Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon +3 more
wiley +1 more source
Crystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue [PDF]
, 2003 peer reviewedThe structures of the, class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a baronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 Angstrom, respectively.
Wouters, J. +4 more
core +3 more sources
Beta-lactamase inhibitors from laboratory to clinic [PDF]
Clinical Microbiology Reviews, 1988 beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against beta-lactam antibiotics. When the beta-lactam ring of this antibiotic class is hydrolyzed, antimicrobial activity is destroyed. Although beta-lactamases have been identified with clinical failures for over 40 years, enzymes with various abilities to hydrolyze specific
openaire +2 more sources
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, EarlyView.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
Exploring the secrets of virus entry: the first respiratory syncytial virus carrying beta lactamase
Frontiers in MicrobiologyBackgroundRespiratory Syncytial Virus (RSV) presents a significant health threat, especially to young children. In-depth understanding of RSV entry mechanisms is essential for effective antiviral development.
Marcio De Ávila-Arias +12 more
doaj +1 more source
Asp-120 Locates Zn2 for Optimal Metallo-β-lactamase Activity [PDF]
, 2007 Metallo-β-lactamases are zinc-dependent hydrolases that inactivate β-lactam antibiotics, rendering bacteria resistant to them. Asp-120 is fully conserved in all metallo-β-lactamases and is central to catalysis.
Bennett, Brian +5 more
core +1 more source
Dynamic energy budget approach to evaluate antibiotic effects on biofilms [PDF]
, 2017 Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix.
Birnir, Bjorn +3 more
core +3 more sources
S1 Guideline on Infected Interdigital Intertrigo (also called Gram‐Negative Toe Web Infection)
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Infected interdigital intertrigo is an exudative, macerating, mixed infection of the toe webs in which gram‐negative bacteria (Pseudomonas aeruginosa and Enterobacterales) seem prevalent, but in which gram‐positive pathogens (Staphylococcus [S.] aureus, streptococci, enterococci) and fungi (dermatophytes, yeasts) also occur.
Christoph Zeyen +10 more
wiley +1 more source
Therapeutic Options for Metallo-β-Lactamase-Producing Enterobacterales
Infection and Drug Resistance, 2021 Xing Tan,1 Hwan Seung Kim,1 Kimberly Baugh,2 Yanqin Huang,1 Neeraja Kadiyala,1 Marisol Wences,1 Nidhi Singh,1 Eric Wenzler,1 Zackery P Bulman1 1Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA ...
Tan X +8 more
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