Determinação fenotípica e genotípica de beta-lactamases de espetro estendido em Escherichia coli, Klebsiella pneumoniae e enterobacter spp. de pacientes internados no Hospital Universitário Professor Polydoro Ernani de São Thiago (HU/UFSC) [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.As enterobactérias são patógenos oportunistas responsáveis por cerca de 70% das infecções urinárias e
Zamparette, Caetana Paes
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Staphylococcal response to daptomycin in implant-associated infections [PDF]
, 2011 The use of medical devices carries the risk of infection. Due to the development of multi-resistant bacteria, missing microcirculation, and biofilm embedded bacteria these implant-associated infections are difficult to treat.
John, Anne-Kathrin
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Beta-lactamase inhibitors from laboratory to clinic [PDF]
Clinical Microbiology Reviews, 1988 beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against beta-lactam antibiotics. When the beta-lactam ring of this antibiotic class is hydrolyzed, antimicrobial activity is destroyed. Although beta-lactamases have been identified with clinical failures for over 40 years, enzymes with various abilities to hydrolyze specific
openaire +2 more sources
Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors [PDF]
, 2010 A small set of boronic acids acting as low nanomolar inhibitors of AmpC beta-lactamase were designed and synthesized in the effort to improve affinity, pharmacokinetic properties, and to provide a valid lead compound.
COSTI, Maria Paola +3 more
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Multiple Drug-Resistant CLABSI from an Extremely Rare Bacterium, Chryseobacterium gleum
Case Reports in Infectious Diseases, 2020 Chryseobacterium gleum is a lactose nonfermenting Gram-negative bacillus (NFGNB) found in soil, plants, and some water sources but rarely implicated as a human pathogen.
David Anson +3 more
doaj +1 more source
Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence
Journal of Periodontal Research, EarlyView.This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo +3 more
wiley +1 more source
Nanomolar beta-lactamase inhibitors [PDF]
New .alpha.-boronated N-alkylamides, R1C(O)NHCHR2B(OH)2 (R1 = H, organyl, excluding R1 = Me, Ph; R2 = heterocyclyl, cycloalkenyl, alkenyl, alkyl), preferably N-acyl-3-aminomethylbenzoates (.alpha.R)-RC(O)NHCH[B(OH)2]-1,3-C6H4X [15-17; X = CO2H, R = Me, 2-
SHOICHET B. K, PRATI, Fabio
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Screening of some medicinal plants from cameroon for beta-lactamase inhibitory activity [PDF]
, 2007 peer reviewedIn efforts to find new bioactive beta-lactamase inhibitors, this study investigated 16 Cameroonian plants belonging to 10 families which were evaluated for anti-beta-lactamase activity. The investigation showed that extracts 2, 6, 3 and 5 of
Ngassam, P. +9 more
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Exploring the secrets of virus entry: the first respiratory syncytial virus carrying beta lactamase
Frontiers in MicrobiologyBackgroundRespiratory Syncytial Virus (RSV) presents a significant health threat, especially to young children. In-depth understanding of RSV entry mechanisms is essential for effective antiviral development.
Marcio De Ávila-Arias +12 more
doaj +1 more source
Frontiers in Microbiology, 2018 Acinetobacter nosocomialis is a member of the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. Increasingly, reports are emerging of the pathogenic profile and multidrug resistance (MDR) phenotype of this species.
Daniel B. Knight +9 more
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