Results 121 to 130 of about 1,353,519 (253)

Point of care tests for hospital-acquired infections (HAIs) : economic analysis report [PDF]

A number of clinical/disease areas have been prioritised by the Technology Strategy Board (TSB) and Department of Health (DH) for the DIIA Innovation Platform.
Szczepura, Ala, Osipenko, Leeza
core  

Genomic and Phenotypic Characterization of Two Novel Enterobacter Phages With EDTA‐Enhanced Antibiofilm Activity

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Two novel lytic Enterobacter phages, HHH and RZH, displayed targeted antibiofilm activity against MDR Enterobacter cloacae complex biofilms when combined with EDTA. Activity was strongest within a narrow low‐millimolar EDTA window, reducing biofilm biomass and viable burden, while higher EDTA concentrations shifted the interaction towards antagonism ...
Kashif Haq, Zac Newland‐Smith, Martin Figgit, David Lee, Kwabena Duedu   +4 more
wiley   +1 more source

In Vitro Activity of Cefaclor/Beta-Lactamases Inhibitors (Clavulanic Acid and Sulbactam) Combination Against Extended-Spectrum Beta-Lactamase Producing Uropathogenic E. coli

Antibiotics
Background: Urinary tract infections (UTIs) caused by the multidrug resistance (MDR) phenotype termed extended-spectrum beta lactamase (ESBL)-producing E. coli is a significant and growing global health concern.
Ali Atoom, Bayan Alzubi, Dana Barakat, Rana Abu-Gheyab, Dalia Ismail-Agha, Awatef Al-Kaabneh, Nawfal Numan   +6 more
doaj   +1 more source

Genetic Diversity and Epidemiological Overlap of Staphylococcus aureus at the Animal–Food–Environment–Human Interface Within a One Health Framework

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Integrating farm‐to‐fork and clinical surveillance, this study reveals distinct SCCmec distributions alongside shared spa types across human, animal, and food interfaces. The results of genetic diversity and epidemiological overlap underscore the critical need for coordinated One Health surveillance to monitor multi‐sectoral Staphylococcus aureus ...
Pinar Sagiroglu, Dursun Alp Gundog, Candan Gungor, Kursat Koskeroglu, Mustafa Altay Atalay, Adalet Dishan, Yeliz Ucar, Aytac Akcay, Huseyin Burak Disli, Harun Hizlisoy, Mukaddes Barel, Tekin Kececi, Nurhan Ertas Onmaz   +12 more
wiley   +1 more source

Repression of Virulence in Staphylococcus aureus by 2‐Aminothiol‐Mediated Quorum Quenching

Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.
Simple analogues of cysteine that can eliminate the native autoinducing peptides (AIPs) of staphylococci extracellularly, before they activate their receptor, and turn off quorum sensing in different Staphylococcus aureus. The elimination of AIPs occurs through a mechanism similar to native chemical ligation (NCL). Further, this strategy showed promise
Bengt H. Gless, Riccardo Milazzo, Martin S. Bojer, Benjamin S. Sereika‐Bejder, Hanne Ingmer, Christian A. Olsen   +5 more
wiley   +2 more sources

Fluoroquinolones versus beta-Lactam/beta-Lactamase Inhibitors in Outpatients with Chronic Obstructive Pulmonary Disease and Pneumonia: A Nationwide Population-Based Study

, 2017
Background ;Studies on the association between antibiotic treatment and outcomes in outpatients with chronic obstructive pulmonary disease (COPD) and pneumonia are scarce. This study aimed to evaluate the effectiveness of fluoroquinolones and beta-lactam/
Lin, Kuan-Yin;Wang, Chi-Chuan;Lin, Chia-Hui;Sheng, Wang-Huei;Chang, Shan-Chwen, 張上淳;王繼娟;盛望徽   +1 more
core   +1 more source

Antibiotic Resistance and Biofilm‐Forming Capacity of Oral Biofilm Bacteria in Patients With Periodontitis and Healthy Individuals

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Key finding: Antimicrobial resistance was common across all groups and associated with biofilm‐forming capacity, an association that remains observational and species‐confounded. ABSTRACT This study aimed to analyse antimicrobial resistance (AMR) in bacterial isolates from subgingival biofilms of patients with periodontitis and supragingival biofilms ...
Nils Werner, Marie Schöffel, Annette Wittmer, Klaus Pelz, Kirstin Vach, Cornelia Frese, Christiane von Ohle, Diana Wolff, Fabian Cieplik, Ali Al‐Ahmad   +9 more
wiley   +1 more source

Multi-Drug Resistant Gram-Negative Sepsis in Neonates: The Special Role of Ceftazidime/Avibactam and Ceftolozane/Tazobactam

Medicines
Neonatal sepsis is a major cause of morbidity and mortality in neonates. A particular concern is the increasing prevalence of antibiotic-resistant strains among neonatal intensive care units (NICUs).
Niki Dermitzaki, Foteini Balomenou, Anastasios Serbis, Natalia Atzemoglou, Lida Giaprou, Maria Baltogianni, Vasileios Giapros   +6 more
doaj   +1 more source

Comparative Genomic Analysis of Multidrug‐Resistant Escherichia coli Across Poultry–Human–Environmental Interfaces

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Whole‐genome sequencing analysis of Escherichia coli isolates from broiler, layer and sonali chickens in Bangladesh shown extensive antimicrobial resistance, diverse virulence factors, plasmid‐mediated resistance, and a highly open pangenome. Comparative genomic analyses demonstrated close genetic relationships with global strains, highlighting the One
Md. Rokibul Hasan Shanto, A. S. M. Ashab Uddin, Md. Shakil Mahmud Supto, Nabil Jahan Mahim, Md. Matiar Rahman Howlader, Syed Sayeem Uddin Ahmed, Md Bashir Uddin   +6 more
wiley   +1 more source

Synthesis and rearrangement of potential zinc beta-lactamase inhibitors.

, 1995
On alkylation of the p-toluene sulfonic salt of benzyl 6-aminopenicillanate (6-APA) with benzyl 2-bromoacetate, the benzyl esters of N-(benzyloxycarbonylmethyl)-6-APA (1) and of N,N-di(benzyloxycarbonylmethyl)-6-APA (3) were obtained. Hydrogenolysis of 1
Vanwetswinkel, S., Van Hove, François, Marchand-Brynaert, Jacqueline, Fastrez, Jacques   +3 more
core   +1 more source