Results 131 to 140 of about 1,353,519 (253)
Comparative Neurotoxicity of Polymyxin B and Colistin in Patients With Cancer
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 10, October 2026.ABSTRACT Background The polymyxins, polymyxin B and colistin, are last‐line options for the treatment of infections caused by drug‐resistant gram‐negative organisms. The comparative neurotoxicity of these agents using contemporary dosing is poorly understood.
Samuel L. Aitken +3 more
wiley +1 more source
Real‐Life Study on Gilteritinib‐Related Infections (GilteRInf): An Italian SEIFEM Study
American Journal of Hematology, Volume 101, Issue 10, Page 2672-2676, October 2026.
Elisa Buzzatti +25 more
wiley +1 more source
Conserved Asp233–Asp246 hydrogen bond modulates active site dynamics in class A β‐lactamases
Protein Science, Volume 35, Issue 10, October 2026.Abstract Rigid enzymes catalyze chemical reactions by stabilizing the transition state through a specific conformation. Catalytic residues are precisely positioned, and enzyme dynamics are kept to a minimum. It is thought that conserved residues around the active site (second‐shell residues) play a crucial role in positioning catalytic residues. Asp233
Cristina V. Lopez‐Gallego +3 more
wiley +1 more source
Current challenges in antimicrobial chemotherapy: focus on beta-lactamase inhibition.
, 2010 peer reviewedThe use of the three classical beta-lactamase inhibitors (clavulanic acid, tazobactam, sulbactam) in combination with beta-lactam antibiotics is currently the most successful strategy to combat the beta-lactamase mediated resistance. However,
Lassaux, Patricia +6 more
core +1 more source
Genomic and Phenotypic Classification of Staphylococcus Species Isolated From Delhi Air
Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.Multiple Staphylococcus spp. were isolated from the outdoor polluted air of the Indian Capital, New Delhi. The bacterial samples were collected from 6 different locations, and the whole genome of four Staphylococcus isolates was sequenced in their entirety. This study presents the comparative genomic analysis of these four isolates.
Himanshu Sen +8 more
wiley +1 more source
Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.Targeted faecal surveillance of conservation‐priority captive ungulates identified multidrug‐resistant nontyphoidal Salmonella and clinically relevant Enterococcus in a UAE urban zoo. These findings provide cross‐sectional baseline evidence supporting cautious integration of zoo‐based monitoring into One Health antimicrobial resistance surveillance ...
Ihab Habib +11 more
wiley +1 more source
Whole-Cell Bioreporter-Based Assay for Detecting Fungal-Derived \u3b2-Lactamase Inhibitors
β-lactams are an important family of antibiotics that are prone to undergo resistance inhibition though the production of β-lactamases by some microorganisms.
Benou, Raz +11 more
core +1 more source
New leads of metallo-beta-lactamase inhibitors from structure-based pharmacophore design
, 2006 We have applied pharmacophore generation, database searching, docking methodologies, and experimental enzyme kinetics to discover new structures for design of di-zinc metallo-beta-lactamase inhibitors. Based on crystal structures of class B1 metallo-beta-
Adolph, Hans-Werner +5 more
core +1 more source
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.ABSTRACT Background Meropenem and piperacillin/tazobactam are commonly used empirical antibiotics in critically ill adults with sepsis, but whether one is superior to the other is uncertain. Methods The Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial is an ongoing investigator‐initiated, randomised ...
Nick Frørup Meier +37 more
wiley +1 more source
Inhibitor-resistant beta-lactamases [PDF]
Journal of Antimicrobial Chemotherapy, 1997 openaire +2 more sources