Simultaneous determination of amoxicillin and clavulanic acid in the human plasma by high performance liquid chromatography: Mass spectrometry (UPLC/MS) [PDF]
Vojnosanitetski Pregled, 2010 Background/Aim. Quantitative analysis of amoxicillin and clavulanic acid in biological matrices requires sensitive and specific methods which allow determination of therapeutic concentration in μg/mL range.
Ćirić Biljana +5 more
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Hepatotoxicity and Antimicrobial Resistance to Amoxicillin and Amoxicillin/Clavulanic Acid: Data Analysis from EudraVigilance [PDF]
MoleculesAmoxicillin is widely prescribed, either as a monotherapy or in combination with clavulanic acid, with its therapeutic indications including a broad range of infections.
Ilaria Ammendolia +7 more
doaj +2 more sources
Combined genomic-proteomic approach in the identification of Campylobacter coli amoxicillin-clavulanic acid resistance mechanism in clinical isolates [PDF]
Frontiers in Microbiology, 2023 IntroductionAminopenicillins resistance among Campylobacter jejuni and Campylobacter coli strains is associated with a single mutation in the promoting region of a chromosomal beta-lactamase blaOXA61, allowing its expression.
Francis Deforet +13 more
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Overproduction of clavulanic acid by extractive fermentation
Electronic Journal of Biotechnology, 2015 Background: Clavulanic acid is an important beta-lactamase inhibitor produced as a secondary metabolite by the actinomycete Streptomyces clavuligerus. Clavulanic acid is chemically unstable; therefore, it is degraded during bacterial cultivation. In this
Cecília Ladeira Lopes Costa +1 more
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Non-operative treatment of acute appendicitis in children: clinical efficacy of amoxicillin-clavulanic acid in a retrospective single-centre study [PDF]
BMJ Paediatrics Open, 2023 Background The success rate of non-operative treatment (NOT) of acute uncomplicated appendicitis (AUA) in children varies from 65% to 95%. There are no recommendations on the appropriate antibiotic therapy.Objective To determine the clinical efficacy of ...
Olivier Abbo +7 more
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A Study on the Production of Clavulanic Acid by Streptomyces clavuligerus using Carbon Resources such as Glucose, Glycerol, and Wheat Bran [PDF]
Biological Journal of Microorganism, 2022 Introduction: Clavulanic acid is the first B-Lactamase inhibitor that has been used clinically since 1981. This inhibitor is the natural product of the fermentation of Streptomyces clavuligerus and is useful for protecting B-lactams against lots of ...
Parisa Akhavan modares +2 more
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Microbiology Spectrum, 2023 As meropenem-clavulanic acid is recommended for the treatment of drug-resistant tuberculosis, the repurposing of new carbapenem combinations may provide new treatment options, including oral alternatives.
Elin Economou Lundeberg +11 more
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Results in Chemistry, 2023 Antibiotic discs used in medical analysis laboratories are sourced from multiple manufacturers and suppliers and must meet stringent quality requirements.
Djibril Diallo +8 more
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Clavulanic acid improves ethanol withdrawal symptoms in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Ethanol withdrawal following chronic use, is an important challenge clinically. In this study, the effect of clavulanic acid was evaluated on the symptoms of ethanol withdrawal in rats.
Ehsan Mohebi +4 more
doaj +1 more source
Antimicrobial Resistance and Infection Control, 2023 Objective We aimed to evaluate the association between post-appendectomy SSI rates and the two most commonly used regimens for perioperative antimicrobial prophylaxis in Swiss children.
Isabella Bielicki +8 more
doaj +1 more source