Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review [PDF]
Frontiers in Microbiology, 2016 The β-lactamase inhibitor, clavulanic acid is frequently used in combination with β-lactam antibiotics to treat a wide spectrum of infectious diseases. Clavulanic acid prevents drug resistance by pathogens against these β-lactam antibiotics by preventing
Sabrina Anne Jacob +2 more
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A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus [PDF]
Beilstein Journal of Organic Chemistry, 2016 The stereochemical course of the cyclisation reaction catalysed by the bacterial 1,8-cineol synthase from Streptomyces clavuligerus was investigated using stereospecifically deuterated substrates.
Jan Rinkel +3 more
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Streptomyces clavuligerus: The Omics Era. [PDF]
J Ind Microbiol Biotechnol, 2021 Abstract The Streptomyces clavuligerus genome consists in a linear chromosome of about 6.7 Mb and four plasmids (pSCL1 to pSCL4), the latter one of 1.8 Mb. Deletion of pSCL4, results in viable mutants with high instability in the chromosome arms, which may lead to chromosome circularisation. Transcriptomic and proteomic studies comparing
Liras P, Martín JF.
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Environmental Factors Modulate the Role of orf21 Sigma Factor in Clavulanic Acid Production in Streptomyces Clavuligerus ATCC27064 [PDF]
Bioengineering, 2022 Sigma factors and sigma factor-related mechanisms control antibiotic production in Streptomyces. In this contribution, the orf21 gene was overexpressed in the wild-type strain of Streptomyces clavuligerus ATCC2764, yielding S.
Luisa F. Patiño +4 more
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TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus [PDF]
Bioengineering, 2021 Streptomyces clavuligerus (S. clavuligerus) has been widely studied for its ability to produce clavulanic acid (CA), a potent inhibitor of β-lactamase enzymes. In this study, S.
Howard Ramirez-Malule +6 more
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Transcriptome profiles of Streptomyces clavuligerus strains producing different titers of clavulanic acid [PDF]
Scientific Data, 2023 Streptomyces clavuligerus NRRL 3585 is a native producer of clavulanic acid (CA), a clinically used β-lactamase inhibitor, and is widely used as an industrial strain for the production of antibiotics.
Junpyo Gong +7 more
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Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064. [PDF]
Appl Microbiol Biotechnol, 2022 Abstract Streptomyces clavuligerus is an industrially important producer of clavulanic acid (CA), a β-lactamase inhibitor which is used together with amoxicillin in one of the most widely prescribed antibacterial medicines, the co-amoxiclav. In a mid-eighties ATCC vial of S.
Pivk Lukančič P +4 more
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Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus [PDF]
Metabolites, 2021 Bacterial specialized metabolites are of immense importance because of their medicinal, industrial, and agricultural applications. Streptomyces clavuligerus is a known producer of such compounds; however, much of its metabolic potential remains unknown ...
Arshad Ali Shaikh +4 more
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Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1 [PDF]
Microbiology Spectrum, 2023 Clavulanic acid (CA) is the preferred clinical drug for the treatment of infections by β-lactam antibiotic-resistant bacteria. CA is produced by Streptomyces clavuligerus, and although there have been many reports on the effects of carbon and nitrogen ...
Jiafang Fu +6 more
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Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing [PDF]
Antibiotics, 2021 Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus).
Víctor A. López-Agudelo +2 more
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