Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus [PDF]
Synthetic and Systems Biotechnology, 2017 The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains ...
Eser Ünsaldı +4 more
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Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1 [PDF]
Microbiology Spectrum, 2023 Clavulanic acid (CA) is the preferred clinical drug for the treatment of infections by β-lactam antibiotic-resistant bacteria. CA is produced by Streptomyces clavuligerus, and although there have been many reports on the effects of carbon and nitrogen ...
Jiafang Fu +6 more
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Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing [PDF]
Antibiotics, 2021 Clavulanic acid (CA) is an irreversible β-lactamase enzyme inhibitor with a weak antibacterial activity produced by Streptomyces clavuligerus (S. clavuligerus).
Víctor A. López-Agudelo +2 more
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A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus [PDF]
Microorganisms, 2020 Streptomyces clavuligerus is a filamentous Gram-positive bacterial producer of the β-lactamase inhibitor clavulanic acid. Antibiotics biosynthesis in the Streptomyces genus is usually triggered by nutritional and environmental perturbations. In this work,
David Gómez-Ríos +6 more
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Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585 [PDF]
Frontiers in Microbiology, 2022 Glycerol is a readily available and low-cost simple polyol compound, which can be used as a carbon source for microorganisms to produce various value-added products. Understanding the underlying regulatory mechanism in glycerol metabolism is critical for
Chaobo Zhang +10 more
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Beyond Clavulanic Acid biosynthesis: Exploring the broad regulatory impact of BldD in Streptomyces clavuligerus ATCC 27064. [PDF]
PLoS ONEBldD is a global regulator of morphological development in Streptomyces, usually acting as a repressor of aerial mycelium formation. However, its role in metabolism and secondary biosynthesis in the wild-type strain Streptomyces clavuligerus remains ...
Luisa F Patiño +2 more
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Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model [PDF]
Data in Brief, 2019 Streptomyces clavuligerus (S. clavuligerus) is a Gram-positive bacterium which produced clavulanic acid (CA) and cephamycin C (CephC). In this data article, a curated genome scale metabolic model of S. clavuligerus is presented.
Stephania Gómez-Cerón +2 more
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Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions [PDF]
Antibiotics, 2019 Background: Clavulanic acid (CA), a β-lactamase inhibitor, is industrially produced by the fermentation of Streptomyces clavuligerus. The efficiency of CA production is associated with media composition, culture conditions and physiological and ...
Laura Pinilla +4 more
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The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1 [PDF]
AMB Express, 2019 During industrial fermentation, Streptomyces clavuligerus F613-1 simultaneously produces primary product clavulanic acid (CA) and cephamycin C. The cephamycin C biosynthetic gene cluster and pathway have been basically elucidated and the CcaR positive ...
Jiafang Fu +7 more
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In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus. [PDF]
PLoS ONE, 2019 In Streptomyces clavuligerus, the gene cluster involved in the biosynthesis of the clinically used β-lactamase inhibitor clavulanic acid contains a gene (orf12 or cpe) encoding a protein with a C-terminal class A β-lactamase-like domain.
Santosh K Srivastava +6 more
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