A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus [PDF]
Microorganisms, 2020 Streptomyces clavuligerus is a filamentous Gram-positive bacterial producer of the β-lactamase inhibitor clavulanic acid. Antibiotics biosynthesis in the Streptomyces genus is usually triggered by nutritional and environmental perturbations. In this work,
David Gómez-Ríos +6 more
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Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585 [PDF]
Frontiers in Microbiology, 2022 Glycerol is a readily available and low-cost simple polyol compound, which can be used as a carbon source for microorganisms to produce various value-added products. Understanding the underlying regulatory mechanism in glycerol metabolism is critical for
Chaobo Zhang +10 more
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Beyond Clavulanic Acid biosynthesis: Exploring the broad regulatory impact of BldD in Streptomyces clavuligerus ATCC 27064. [PDF]
PLoS ONEBldD is a global regulator of morphological development in Streptomyces, usually acting as a repressor of aerial mycelium formation. However, its role in metabolism and secondary biosynthesis in the wild-type strain Streptomyces clavuligerus remains ...
Luisa F Patiño +2 more
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Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis [PDF]
Frontiers in Microbiology, 2019 Expression of non-native transcriptional activators may be a powerful general method to activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose archetype is PimM, activate the biosynthesis of polyene macrolide antifungals and ...
Yolanda Martínez-Burgo +9 more
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Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model [PDF]
Data in Brief, 2019 Streptomyces clavuligerus (S. clavuligerus) is a Gram-positive bacterium which produced clavulanic acid (CA) and cephamycin C (CephC). In this data article, a curated genome scale metabolic model of S. clavuligerus is presented.
Stephania Gómez-Cerón +2 more
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Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions [PDF]
Antibiotics, 2019 Background: Clavulanic acid (CA), a β-lactamase inhibitor, is industrially produced by the fermentation of Streptomyces clavuligerus. The efficiency of CA production is associated with media composition, culture conditions and physiological and ...
Laura Pinilla +4 more
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The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1 [PDF]
AMB Express, 2019 During industrial fermentation, Streptomyces clavuligerus F613-1 simultaneously produces primary product clavulanic acid (CA) and cephamycin C. The cephamycin C biosynthetic gene cluster and pathway have been basically elucidated and the CcaR positive ...
Jiafang Fu +7 more
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Simultaneous solid–liquid separation and primary purification of clavulanic acid from fermentation broth of Streptomyces clavuligerus using salting‐out extraction system [PDF]
Engineering in Life Sciences, 2021 Clavulanic acid (CA) is usually used together with other β‐lactam antibiotics as combination drugs to inhibit bacterial β‐lactamases, which is mainly produced from the fermentation of microorganism such as Streptomyces clavuligerus. Recently, it is still
Xu‐Dong Wang +6 more
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Cell density influences antibiotic biosynthesis in Streptomyces clavuligerus [PDF]
Microbiology (United Kingdom), 1996 Production of cephamycin C and clavulanic acid by Streptomyces clavuligerus took place during the exponential phase of growth in a defined medium. Both antibiotic biosynthetic pathways were activated shortly after spore germination, but the timing and kinetics of activation were affected by inoculum density.
Alfredo F Brana
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Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus [PDF]
Synthetic and Systems Biotechnology, 2017 The usefulness of genetic/metabolic engineering for further improvement of industrial strains is subject of discussion because of the general lack of knowledge on genetic alterations introduced by iterative cycles of random mutagenesis in such strains ...
Eser Ünsaldı +4 more
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