Results 41 to 50 of about 1,344 (153)
Electronic Journal of Biotechnology, 2017 Background: Streptomyces clavuligerus was the producer of clavulanic acid, claR, a pathway-specific transcriptional regulator in S. clavuligerus, positively regulates clavulanic acid biosynthesis.
Ronghuo Qin +5 more
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ChemBioChem, Volume 24, Issue 23, December 1, 2023., 2023 A high yielding sesquiterpene synthase for (+)‐1‐epi‐cubenol from the actinomycete Nonomuraea coxensis was investigated for its cyclisation mechanism by isotopic labelling experiments. Several derivatives of (+)‐1‐epi‐cubenol and of the plant derived compounds (−)‐cubenol and (−)‐1‐epi‐cubenol have been prepared, including an epoxide that is known as a
Jeroen S. Dickschat +2 more
wiley +1 more source
ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022 Housing sulfur: Certain fungi produce diketopiperazine compounds with a transannular sulfur bridge. These so‐called epipolythiodioxopiperzines are toxic by non‐specifically interacting with intracellular proteins and contribute to fungal pathogenicity. Producer strains serve as bio‐pesticides but also question safety of food fermentation.
Eva M. Huber
wiley +1 more source
Screening of Natural β-lactamase Inhibitors (BLIPs) from Two Newly Isolated Egyptian Streptomyces strains [PDF]
Research Journal of Applied Biotechnology, 2023 β-lactam antibiotics are the most extensively used antibiotics to treat a variety of infections due to their safety, high selectivity, and efficacy.
Borhan Eltabey +3 more
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Antibiotics, 2022 Naringenin and its glycosylated derivative naringin are flavonoids that are synthesized by the phenylpropanoid pathway in plants. We found that naringenin is also formed by the actinobacterium Streptomyces clavuligerus, a well-known microorganism used to
Juan F. Martín, Paloma Liras
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Genome dynamics of Streptomyces clavuligerus
Access Microbiology, 2019 Streptomyces clavuligerus is the producer of clavulanic acid; aβ-lactamaseinhibitor that is used in combination with the antibiotic amoxicillin. Genome sequencing has established that S. clavuligerus contains a linear chromosome and four linear plasmids: pSCL1, pSCL2, pSCL3 and pSCL4.
Lis Algora, Paul Herron
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Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus [PDF]
Journal of General Microbiology, 1991 Cephalosporin biosynthetic activity and extracellular protease production increased during growth of Streptomyces clavuligerus in defined medium, while the level of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) remained very low and stable. Cephalosporin biosynthesis (measured in resting cell systems) was initiated during early exponential growth in ...
V, Bascarán +3 more
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Antimicrobial Agents and Chemotherapy, 1980 Penicillin-binding proteins of three Streptomyces strains, S. cacaoi, S. olivaceus, and S. clavuligerus, were examined by gel electrophoresis and fluorography. In a beta-lactamase producer, S. cacaoi, at least five membrane-bound penicillin-binding proteins were detected, but in two beta-lactam producers, S. olivaceus and S.
H, Ogawara, S, Horikawa
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Isolation and Characterization of Nitrogen-deregulated Mutants of Streptomyces clavuligerus [PDF]
Microbiology, 1989 Two screening methods for isolation of mutants of Streptomyces clavuligerus with altered control of nitrogen metabolism enzymes are described. Thirty-eight prototrophic mutants with simultaneous deregulation of urease and glutamine synthetase were isolated. Nine mutants were examined in more detail and they also showed deregulated formation of arginase
V, Bascarán, C, Hardisson, A F, Braña
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Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus [PDF]
Microbiology, 1997 This paper reports a novel use of cluster analysis for the identification of intermediary metabolites that are produced at rates closely correlated with those of antibiotic biosynthesis. This information was used to devise culture feeds resulting in enhanced production of clavulanic acid, an antibiotic of current worldwide commercial interest.
Paul R, Ives, Michael E, Bushell
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